Asian Journal of Research in Chemistry

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UV Spectrophotometric Method Development and Validation for Estimation of Doxycycline Hydrochloride in Bulk and Capsule Dosage Form


Affiliations
1 KNGD Modi Institute of Pharmaceutical Education and Research, Modinagar, U. P.-201204
2 Dr. K. N. Modi Institute of Pharmaceutical Education and Research, Modinagar, U. P.-201204
     

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A novel, simple, sensitive and rapid UV Spectrophotometric method was developed for the estimation of Doxycycline hydrochloride in bulk and its pharmaceutical capsule dosage forms. Doxycycline hydrochloride exhibited maximum absorbance at 271 nm in distilled water and obeyed linearity in the concentration range of 5-35 ppm. The proposed method has been applied successfully for the analysis of Doxycycline hydrochloride either in bulk or pharmaceutical capsule dosage forms with good accuracy and precision. The method herein described can be employed for quality control and routine analysis of Doxycycline hydrochloride in pharmaceutical capsule dosage forms

Keywords

Doxycycline Hydrochloride, UV Spectrophotometry, Maximum Absorbance, Bulk, Capsule
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  • UV Spectrophotometric Method Development and Validation for Estimation of Doxycycline Hydrochloride in Bulk and Capsule Dosage Form

Abstract Views: 416  |  PDF Views: 2

Authors

Singh Kumar Rakesh
KNGD Modi Institute of Pharmaceutical Education and Research, Modinagar, U. P.-201204
Patel Singh Pankaj
KNGD Modi Institute of Pharmaceutical Education and Research, Modinagar, U. P.-201204
V. K Sharma
KNGD Modi Institute of Pharmaceutical Education and Research, Modinagar, U. P.-201204
R. K Roy
Dr. K. N. Modi Institute of Pharmaceutical Education and Research, Modinagar, U. P.-201204

Abstract


A novel, simple, sensitive and rapid UV Spectrophotometric method was developed for the estimation of Doxycycline hydrochloride in bulk and its pharmaceutical capsule dosage forms. Doxycycline hydrochloride exhibited maximum absorbance at 271 nm in distilled water and obeyed linearity in the concentration range of 5-35 ppm. The proposed method has been applied successfully for the analysis of Doxycycline hydrochloride either in bulk or pharmaceutical capsule dosage forms with good accuracy and precision. The method herein described can be employed for quality control and routine analysis of Doxycycline hydrochloride in pharmaceutical capsule dosage forms

Keywords


Doxycycline Hydrochloride, UV Spectrophotometry, Maximum Absorbance, Bulk, Capsule

References