Asian Journal of Research in Chemistry

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Synthesis and Identification of Mono and Bicyclic Compounds Containing Dinitrogen Atoms as Anesthetic


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1 Assist. Prof., Chem. Dept., College of Education, University of Kufa Iraq
     

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In this study , mono and bicyclic compounds [1-8] were synthesized by alkalytion of 2-aminothiozoline with carbonyl compounds (succinic acid ., chloro aceticacid .,2,5-hexan-dione ., 3-chloro propoyl chloride ), where as the compounds [9-12] were synthesized by condensation between diketone compounds with (2-amino benzothiazole ,guanine) . The synthesized compounds structures were characterized by several methods: {(C.H.N)-analysis , FT.IR-spectra , H.NMR-spectra } and melting points.

Keywords

Bicyclic, Pharmaceutical Analgesic
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  • Hussein .I. ,Adnan .A, Hassan . A, Alaa .A , Ghada .S, Justice .T, Mary .H & Jochen . L ., (2008) ,"Synthesis and antimicrobial evalution of new isoxazol derivatives", Arch . Pharm . Chem .life Sci , 341 ,(81-89)

  • Jumat .S ,Nadia .S , Hassan .H & Emad .Y., (2009),"Pharmacological activities of some hetrocyclic compounds", European .J.Sci Res .,31 ,2 , 256-264. 3. Nagham.M.Aljamali ., (2012), Asian .J . Exp . Chem. , 7,1, 52- 56.

  • Shui.M and Howard.A .,(2005) ,J. Am.Chem.Soc., 127, 1477- 14784.. , Cited by IVSL of Iraq.

  • Prabal.P ,Ashok.Y , and Hiriyakkanavar.J .,(2011), Eur.J.Org.Chem, 4001-4007.. , Cited by IVSL of Iraq.

  • Nagham.M.Aljamali., (2013), Pharma. INN.J., 1,11,73.

  • Rang . H , Dale . M and Ritter .,(2005),"Hetrocyclic compounds in pharmacology", J in Pharmacology , 5th ed , Churchill Living – Stone , Newyork , 503 – 515.

  • Lehmann . J , Hussein . I and Hassan . A ., (2004) ,"Synthesis of hetrocyclic derivatives with antioxidant activity",German Patent , Dec . 9 , DE 103 20 732 A1.

  • Said . A , Khadija . O and Ismail . A .,(2007) ,"Synthesis of several derivatives of oxazole compounds", Bellstein . J . Org . Chem. , 3:15.

  • Stockman . A ., (2003). ,"study effect of bicyclic compounds on fungi",Annu . Rep . Prog . Chem. , Sect . B , 99 , 161 – 182

  • Nicolaou . K , Baran . P , Zhong . Y and Sugita . K .,(2002), "antimicrobial activity of bicyclic compounds", J . Am . Chem. Soc ., 124 , 10 , 2212 – 2219.

  • Abass . M and Hassan . A .,(2003) ,"cytotoxic and antibacterial of cyclic compounds", Chem. Pap ., 57 , 4 , 267 – 277.

  • Mourad . A , Ashraf . A , Hassan . H and Eman . A ., (2007) , "Synthesis and identification of pyrazol with cyclic derivatives",Beilstein . J . Org . Chem. , 3:11.

  • Saleh . M and Moustafa . Sh .,(2007)," Synthesis ,stereochemistry of bicyclic compounds from thiazolidine", Beilstein . J . Org . Chem. , 3:12.

  • Ross . M , Borazjani . A , Edward .C and Potter. P., (2006),"Synthesis of vaniline fused with some hetrocyclic compounds", Bio Chem. Pharmacol ., 17 , 657 – 669.

  • Baranczewski . P , Stanczak . A , Kautiainen . A , Sandin . P and Edlund . P.,(2006)," Synthesis of medicinal drugs from hetrocyclic compounds", Pharmacol . Rep ., 58 , 341 – 352.

  • Pelkonen .O and Raunio . H .,(2005) ,"Synthesis of N-cyclic compounds as microbial activity", Expert . Opin . Drug Metab . Toxicol ., 1 , 49 – 59.

  • Boelsterli . U .,(2002) ,"diazepam compounds with cyclization reaction", Curr . Drug Metab , 3 , 439 – 450.

  • Prabhu . S , Fackett . A , Lloyd . S and Mcclellan . H .,(2002), "Cyclization of thizole with hetrocyclic compounds", Chem. Biol. Interact ., 142 , 83 – 97.

  • Morono . Y , Takano . S , Miyanaga . K and Tanji . Y .,(2004), "Synthesis of fused ring of nitrogen compounds", Biotechnol . Lett ., 26 , 379 – 383.


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  • Synthesis and Identification of Mono and Bicyclic Compounds Containing Dinitrogen Atoms as Anesthetic

Abstract Views: 447  |  PDF Views: 2

Authors

Nagham Mahmood Aljamali
Assist. Prof., Chem. Dept., College of Education, University of Kufa Iraq

Abstract


In this study , mono and bicyclic compounds [1-8] were synthesized by alkalytion of 2-aminothiozoline with carbonyl compounds (succinic acid ., chloro aceticacid .,2,5-hexan-dione ., 3-chloro propoyl chloride ), where as the compounds [9-12] were synthesized by condensation between diketone compounds with (2-amino benzothiazole ,guanine) . The synthesized compounds structures were characterized by several methods: {(C.H.N)-analysis , FT.IR-spectra , H.NMR-spectra } and melting points.

Keywords


Bicyclic, Pharmaceutical Analgesic

References