Asian Journal of Research in Chemistry

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1,2,3,4-Tetrahydroquinoline Derivatives and its Significance in Medicinal Chemistry


Affiliations
1 Department of Pharmaceutical Chemistry, Parul Institute of Pharmacy, Limda-391 760, Vadodara, Gujarat, India
     

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1,2,3,4-Tetrahydroquinoline derivatives are the most important class of compounds in the pharmaceutical and agrochemical industries and play important role in the field of medicinal chemistry with so many Pharmacological activities such as anti-cancer, anti-diabetic, anti-parasitic, anti-inflammatory, anti-oxidant, adrenergic, anti-HIV, antialzheimer, anti-hyperlipidemic, activities. The tetrahydroquinoline ring containing system found in numerous biologically active natural products and pharmacologically relevant therapeutic agents and very common structure motif. Because of the significance of these scaffolds in medicinal chemistry, the development of some potent and important amalgams continues to be a very active field in development of a promising target for new drug development. 1,2,3,4-Tetrahydroquinoline is one such important part of pharmacophore and having different pharmacological activities. Here we have introduced different 1,2,3,4-tetrahydroquinoline derivatives which possess different biological activities depends on its types and position of substituted functional groups. This review is summarized to know about the chemistry of different 1,2,3,4-tetrahydroquinoline derivatives along with their pharmacological activities.

Keywords

1,2,3,4-tetrahydroquinoline, Anti-cancer, Anti-cancer, Anti-diabetic, Anti-parasitic, Antiinflammatory
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  • 1,2,3,4-Tetrahydroquinoline Derivatives and its Significance in Medicinal Chemistry

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Authors

Prafulla M Sabale
Department of Pharmaceutical Chemistry, Parul Institute of Pharmacy, Limda-391 760, Vadodara, Gujarat, India
Pratik Patel
Department of Pharmaceutical Chemistry, Parul Institute of Pharmacy, Limda-391 760, Vadodara, Gujarat, India
Prabhjot Kaur
Department of Pharmaceutical Chemistry, Parul Institute of Pharmacy, Limda-391 760, Vadodara, Gujarat, India

Abstract


1,2,3,4-Tetrahydroquinoline derivatives are the most important class of compounds in the pharmaceutical and agrochemical industries and play important role in the field of medicinal chemistry with so many Pharmacological activities such as anti-cancer, anti-diabetic, anti-parasitic, anti-inflammatory, anti-oxidant, adrenergic, anti-HIV, antialzheimer, anti-hyperlipidemic, activities. The tetrahydroquinoline ring containing system found in numerous biologically active natural products and pharmacologically relevant therapeutic agents and very common structure motif. Because of the significance of these scaffolds in medicinal chemistry, the development of some potent and important amalgams continues to be a very active field in development of a promising target for new drug development. 1,2,3,4-Tetrahydroquinoline is one such important part of pharmacophore and having different pharmacological activities. Here we have introduced different 1,2,3,4-tetrahydroquinoline derivatives which possess different biological activities depends on its types and position of substituted functional groups. This review is summarized to know about the chemistry of different 1,2,3,4-tetrahydroquinoline derivatives along with their pharmacological activities.

Keywords


1,2,3,4-tetrahydroquinoline, Anti-cancer, Anti-cancer, Anti-diabetic, Anti-parasitic, Antiinflammatory

References