Asian Journal of Research in Chemistry

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Synthesis, Characterization and Biological Activities of some Novel Oxadiazole Derivatives


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1 Shri JJT University, Vidyanagari, Churu Jhunjhunu Road, Chudela, District-Jhunjhunu, Rajasthan-333001
     

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The synthesis of novel derivatives of 1,3,4-oxadiazole are reported. All the synthesized amides are characterized standard spectroscopic method and elemental analysis techniques. Synthesized compounds are screened for microbial and cytotoxic activities.

Keywords

Oxadiazole, Antibaceterial, Antifungal, Cytotoxicity
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  • Bishayee A et al. Vanadium-mediated chemoprotection against chemical hepatocarcinogenesis in rats: haematological and histological characteristics. European Journal of Cancer Prevention. 6; 1977: 58–70.

  • Chitamber CR. and Wereley JP. Resistance to the antitumor agent gallium nitrate in human leukemic cells is associated with decreased gallium/iron uptake, increased activity of iron regulatory protein-1, and decreased ferritin production. Journal of Biological Chemistry. 272; 1997: 12151–12157.

  • Jain N et al. Syntheses and antibacterial studies of some 2-[5- (aryl)-[1,3,4]oxadiazole-2-ylsulfanyl] alkanoic acids. Journal of Iranian Chemical Society. 6; 2009: 77–81.

  • Hutt MP, Elstager EF. and Werbet LM. 2-Phenyl-5- (trichloromethyl)-1,3,4-oxadiazoles, a new class of antimalarial substances. Journal of Heterocyclic Chemistry. 7; 1970: 511–518.

  • Silvestrini B. and Pagatti C. Pharmacological properties of 3- phenyl-5b-diethylaminoethyl-1,2,4-oxadiazole. Brazilian Journal of Pharmacology. 16; 1961: 209–217.

  • Sharma RS. and Bahel SC. Synthesis of aryloxy/aryl acetyl thiosemicarbazides, substituted 1,3,4-oxadiazoles, 1,3,4- thiadiazoles, 1,2,4-triazoles and related compounds as potential fungicides. Journal of Indian Chemical Society. 59; 1982: 877– 880.

  • Omar A, Mohsen ME. and Aboul Wafa OM. Synthesis and anticonvulsant properties of a novel series of 2-substituted amino-5-aryl-1,3,4-oxadiazole derivatives. Journal of Heterocyclic Chemistry. 21; 1984: 1415–1418.

  • Prajapati AK. and Modi VP. Bent-shaped mesogenic oxadiazole and thiadiazole derivatives from rodshaped mesogenic hydrazide containing polar chloro group. Liquid Crystal. 37; 2010: 407– 415.

  • Prajapati AK. and Modi VP. Bent-shaped mesogenic oxadiazoles and thiadiazoles with terminal methyl group. Phase Transitions. 83; 2010: 634–649.

  • Prajapati AK. and Modi VP. Mesogenic bent-shaped nitrooxadiazoles and thiadiazoles. Liq. Cryst. 38; 2011: 191–199.

  • Varma RS. Solvent-free organic syntheses using supported reagents and microwave irradiation. Green Chemistry. 43; 1999: 55.

  • Aurangzeb H, Noel FT. and Shelly G. Synthesis, characterization and antifungal evaluation of 5-substituted-4-amino-1,2,4- triazole-3-thioesters. Molecules. 16; 2011: 1297–1309.

  • Barry AL. The Antimicrobial Susceptibility Test: Principle and Practices, IIIus Leu, Febiger, Philadelphia, PA, USA, 1976.


Abstract Views: 284

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  • Synthesis, Characterization and Biological Activities of some Novel Oxadiazole Derivatives

Abstract Views: 284  |  PDF Views: 2

Authors

Vishal Modi
Shri JJT University, Vidyanagari, Churu Jhunjhunu Road, Chudela, District-Jhunjhunu, Rajasthan-333001
Rajesh S. Shah
Shri JJT University, Vidyanagari, Churu Jhunjhunu Road, Chudela, District-Jhunjhunu, Rajasthan-333001

Abstract


The synthesis of novel derivatives of 1,3,4-oxadiazole are reported. All the synthesized amides are characterized standard spectroscopic method and elemental analysis techniques. Synthesized compounds are screened for microbial and cytotoxic activities.

Keywords


Oxadiazole, Antibaceterial, Antifungal, Cytotoxicity

References