Asian Journal of Research in Chemistry

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Synthesis, Characterization and Antimicrobial Activity of Novel Chalcones from 1-[4-(1H-imidazol-1-yl) Phenyl] Ethanone


Affiliations
1 Assistant Professor, NRI College of Pharmacy, Pothavarapadu Village, Agirapalli (M) A.P.
2 Professor, Nirmala College of Pharmacy, Atmakur Village, Mangalagiri Mandal, Guntur Dt, A.P - 522 503
3 Principal & Professor, ANU College of Pharmaceutical Science, Nagarjuna Nagar, Acharya Nagarjuna University, Guntur-530 003, (A.P),
4 Assistant Professor, QIS College of Pharmacy, Vengamukkala Palem, Ongole, A.P-523272
     

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Chalcones were synthesized by condensing 1-[4-(1H-imidazol-1-yl) phenyl] ethanone with aromatic aldehydes derivatives in dilute ethanolic sodium hydroxide solution at room temperature according to Claisen-Schmidt condensation. All these compounds were characterized by means of their IR, 1H NMR spectroscopic data and microanalyses. The antimicrobial activity of these compounds was evaluated by the cup plate method.

Keywords

Chalcones, Synthesis, Antimicrobial activity
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  • Synthesis, Characterization and Antimicrobial Activity of Novel Chalcones from 1-[4-(1H-imidazol-1-yl) Phenyl] Ethanone

Abstract Views: 388  |  PDF Views: 5

Authors

Gondu Eswara Rao
Assistant Professor, NRI College of Pharmacy, Pothavarapadu Village, Agirapalli (M) A.P.
S.A. Rahaman
Professor, Nirmala College of Pharmacy, Atmakur Village, Mangalagiri Mandal, Guntur Dt, A.P - 522 503
A. Prameela Rani
Principal & Professor, ANU College of Pharmaceutical Science, Nagarjuna Nagar, Acharya Nagarjuna University, Guntur-530 003, (A.P),
M.M. Prasada Rao
Assistant Professor, QIS College of Pharmacy, Vengamukkala Palem, Ongole, A.P-523272

Abstract


Chalcones were synthesized by condensing 1-[4-(1H-imidazol-1-yl) phenyl] ethanone with aromatic aldehydes derivatives in dilute ethanolic sodium hydroxide solution at room temperature according to Claisen-Schmidt condensation. All these compounds were characterized by means of their IR, 1H NMR spectroscopic data and microanalyses. The antimicrobial activity of these compounds was evaluated by the cup plate method.

Keywords


Chalcones, Synthesis, Antimicrobial activity

References