Asian Journal of Research in Chemistry

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Darivatization and Pharmacological Evaluation of New 4 Substituted 5 -phenyl-3-mercapto-1,2,4-Triazoles


Affiliations
1 Jyothishmathi Institute of Pharmaceutical Science, Ramakrishna colony, Karimnagar, AP, India
2 Talla Padmavathi College of Pharmacy, ours, Karimabad, Warangal, AP, India
3 Procadence Institute of Pharmaceutical Sciences. Gajwel, Medak,. A.P, India
4 Jyothishmathi Institute of Pharmaceutical Science, Ramakrishna colony, Karimnagar, AP
     

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An efficient method for synthesis of 4 substituted 5 -phenyl - 3- mercapto -1, 2, 4 -triazole, by the mode of ring cleavage of oxadiazoles, nucleophiles are readily attack 5-phenyl 1,3,4- oxadiazole-2 - thiols and they are cleaved by acids and basis, in a reaction, which is the reverse of the ring closure, many nucleophilic ring cleavage reaction are followed by recyclization to give different heterocyclics, we were sysnthsized 5 different compounds and characterized its physical data, spectral analysis by IR and these compounds screened for possible CNS activity.

Keywords

Triazoles, Oxadiazole, Grass Behavior Study, Locomotor Activity
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  • Xiangl, xue Qiang-Li et al. synthesis and evaluation of anti tumor activity of novel chiral 1,2,4- triazole Schiff bases bearing -butenolide moiety, Organic and Spinger Open J 2012

  • Hasn, S. Gapi and I Khan, Asian J. Chem, 23,2007(2011).

  • Turner, R.A. Screening methods in pharmacology, Academic Press; New York (1965)72-79.

  • Vogel H Gerhard: drug discovery and evaluation of pharmacological assays (Springer-Verlag Berlin Heidelberg New York 2002) 126-128

  • Bijul Laxman A and R L Gupta. Fungitoxicity and QSAR of 4- amino-5- substituted aryl-3-mercapto- (4H)-1,2,4- triazoles, Indian Journal of Chemistry, Vol 49B sep2010 pp1235-1242.

  • Gestel J V. Heeres J. Janseen M and Reet G V, Pestic Science, 11 1980, 95.

  • Nizamuddin, Gupta M, Khan MH and Srivastava M K, J Scient Ind Res,58,1999,538.

  • cande SN and Jagtap S R, Indian J Chem.36B, 1997,199.


Abstract Views: 339

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  • Darivatization and Pharmacological Evaluation of New 4 Substituted 5 -phenyl-3-mercapto-1,2,4-Triazoles

Abstract Views: 339  |  PDF Views: 2

Authors

M. Vidyasagar
Jyothishmathi Institute of Pharmaceutical Science, Ramakrishna colony, Karimnagar, AP, India
B. Srinivas
Talla Padmavathi College of Pharmacy, ours, Karimabad, Warangal, AP, India
P. Parameshwar
Jyothishmathi Institute of Pharmaceutical Science, Ramakrishna colony, Karimnagar, AP, India
A. Ganesh
Procadence Institute of Pharmaceutical Sciences. Gajwel, Medak,. A.P, India
R. Ramesh Kumar
Jyothishmathi Institute of Pharmaceutical Science, Ramakrishna colony, Karimnagar, AP

Abstract


An efficient method for synthesis of 4 substituted 5 -phenyl - 3- mercapto -1, 2, 4 -triazole, by the mode of ring cleavage of oxadiazoles, nucleophiles are readily attack 5-phenyl 1,3,4- oxadiazole-2 - thiols and they are cleaved by acids and basis, in a reaction, which is the reverse of the ring closure, many nucleophilic ring cleavage reaction are followed by recyclization to give different heterocyclics, we were sysnthsized 5 different compounds and characterized its physical data, spectral analysis by IR and these compounds screened for possible CNS activity.

Keywords


Triazoles, Oxadiazole, Grass Behavior Study, Locomotor Activity

References