Asian Journal of Research in Chemistry

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A RP-HPLC Method Development and Its Validation for the Simultaneous Estimation of Naproxen and Pantoprazole Sodium in Capsule Dosage Form


Affiliations
1 Department of Pharmaceutical Analysis, JNTUA - Oil Technological Research Institute, Anantapur -515001, Andhra Pradesh
     

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A simple, sensitive, and precise High performance liquid chromatographic method for the analysis of Naproxen and Pantoprazole has been developed and validated for the determination of compounds in commercial pharmaceutical products. The compounds were well separated on a BDS Hypersil C-18 reversed-phase column by use of a mobile phase consisting of Acetonitrile and Mixed Phosphate buffer (pH 6.92) in 45:55(V/V%) ratio, at a flow rate of 1.0 mL/min with detection wavelength at 290 nm. The linearity ranges were 20-120μg. The correlation coefficient was found to be 0.997 and 0.995 for Naproxen and Pantoprazole respectively. The recovery amount was in the range of 99.67-101.39%. The high recovery and low relative standard deviation confirms the suitability of the method for determination of Naproxen and Pantoprazole in capsule dosage forms.

Keywords

Naproxen, Pantoprazole
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  • Antonio Segura Carretero, Carmen Cruces-Blanco, Ramirez Garcia M, Canabate B, Alberto Fernandez, Tierrez, Simple and rapid determination of the drug naproxen in pharmaceutical preparations by heavy atom-induced room temperature phosphorescence, Talanta 50 (1999) 401–407.

  • Okramzenitadevi, Validated spectrophotometric determination of Pantoprazole sodium pharmaceutical using ferric chloride and two chelating agents, International Journal of Chem. tech Research., vol.2 (1); 2010: 624-632.

  • Tasnuvahaque, Mesbahuddintalukder, Development and validation of a RP-HPLC method for simultaneous estimation of naproxen and ranitidine hydrochloride, Pak. J. Pharm. Sci. Vol.23, (4); 2010: 379-383.

  • Serenkayiran, sibelbozdag, pehlivan, mustafacelebier, Determination of naproxen sodium from poly (lactide-coglycolide) corneal scaffolds, Turk j. Pharm. Sci .7(1); 2010: 57- 68.

  • Shubhangi, Pawar, Jitendra M, Fegade D and Rajesh, Chaudhari Y, Validated RP-HPLC Method for Simultaneous Quantitation of Domperidone Maleate and Naproxen Sodium in Bulk Drug and Formulation, Scholar Research Library. 2(5); 2010: 229-236.


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  • A RP-HPLC Method Development and Its Validation for the Simultaneous Estimation of Naproxen and Pantoprazole Sodium in Capsule Dosage Form

Abstract Views: 451  |  PDF Views: 2

Authors

S Rubesh Kumar
Department of Pharmaceutical Analysis, JNTUA - Oil Technological Research Institute, Anantapur -515001, Andhra Pradesh
G Usha Sree
Department of Pharmaceutical Analysis, JNTUA - Oil Technological Research Institute, Anantapur -515001, Andhra Pradesh
K Jayanthi
Department of Pharmaceutical Analysis, JNTUA - Oil Technological Research Institute, Anantapur -515001, Andhra Pradesh
B Naga Malleswara Babu
Department of Pharmaceutical Analysis, JNTUA - Oil Technological Research Institute, Anantapur -515001, Andhra Pradesh
N Duganath
Department of Pharmaceutical Analysis, JNTUA - Oil Technological Research Institute, Anantapur -515001, Andhra Pradesh
N Devanna
Department of Pharmaceutical Analysis, JNTUA - Oil Technological Research Institute, Anantapur -515001, Andhra Pradesh

Abstract


A simple, sensitive, and precise High performance liquid chromatographic method for the analysis of Naproxen and Pantoprazole has been developed and validated for the determination of compounds in commercial pharmaceutical products. The compounds were well separated on a BDS Hypersil C-18 reversed-phase column by use of a mobile phase consisting of Acetonitrile and Mixed Phosphate buffer (pH 6.92) in 45:55(V/V%) ratio, at a flow rate of 1.0 mL/min with detection wavelength at 290 nm. The linearity ranges were 20-120μg. The correlation coefficient was found to be 0.997 and 0.995 for Naproxen and Pantoprazole respectively. The recovery amount was in the range of 99.67-101.39%. The high recovery and low relative standard deviation confirms the suitability of the method for determination of Naproxen and Pantoprazole in capsule dosage forms.

Keywords


Naproxen, Pantoprazole

References