Asian Journal of Research in Chemistry

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Synthesis and Characterization of Novel Bio-Elastomers for Tissue Engineering


Affiliations
1 PG and Research Department of Chemistry, Presidency College, Chennai – 600 005
     

   Subscribe/Renew Journal


Biodegradable elastomers have recently found widespread application in many areas of biomedical engineering such as tissue engineering, therapeutic delivery and bioimaging. Recent developments led to development of elastomers involving citric acid based polyesters are being explored that are endogenous to the human metabolism. In terms of mechanical stability, crystallinity, hydrophobicity and biocompatibility, polyesters synthesised from these monomers can display a wide range of applications. In this investigation, a series of novel bio-elastomers based on citric acid were synthesised by catalyst free polycondensation reaction. These polymers were characterised by solubility, IR, 1H NMR spectral analysis, thermal and mechanical studies. The physicochemical properties of the synthesised polymers are controlled by the variation of monomers in polycondensation reaction forms a pivotal role in the synthesis.

Keywords

Biodegradable Elastomers, Biocompatibility, Polycondensation, Spectral Analysis
Subscription Login to verify subscription
User
Notifications
Font Size


  • Middleton, J. C.; Tipton, A. J. Biomaterials 2000; 21:2335–2346.

  • Schwendeman, S.; Costantino, H. R.; Gupta, R. K.; Langer, R. In Controlled Drug Delivery: Challenges and Strategies; Park, K., Ed.; American Chemical Society: Washington, DC 1997; pp 229- 267.

  • Domb, A. J., Wiseman, D. M., Eds.; Handbook of Biodegradable Polymers; CRC Press: Boca Raton, FL 1998.

  • Nair, L. S.; Laurencin, C. T. Prog. Polym. Sciense 2007; 32:762– 798.

  • Kim, S.; Kim, J. H.; Jeon, O.; Kwon, I. C.; Park, K. Eur. J. Pharm. Biopharm 2009; 71:420–430.

  • Bajpai, A. K.; Shukla, S. K.; Bhanu, S.; Kankane, S. Prog. Polym. Sci 2008; 33:1088–1118.

  • Chiellini, E.; Bemporad, L.; Solaro, R. J. Bioact. Compat. Polym 1994; 9:152–169.

  • Chiellini, E.; Faggioni, S.; Solaro, R. J. Bioact. Compat. Polym 1990; 5:16–29.

  • Wang Y, Ameer GA, Sheppard BJ, Langer R. Nature Biotechnol. 2002; 20:602.

  • Yang J, Webb AR, Pickerill SJ, Hageman G, Ameer GA. Biomaterials.2006; 27:1889.

  • Yang J, Motlagh D, Allen JB, Webb AR, Kibbe MR, Aalami O, et al., Adv Mater 2006; 18(12):1493–8.

  • Porter D, Vollrath F. Silk as a biomimetic ideal for structural polymers. Adv Mater 2009; 21: 487-492.

  • Tran RT, Zhang Y, Gyawali D, Yang J. Recent Pat Biomed Eng. 2009; 2:216.

  • Qiu HJ, Yang J, Kodali P, Koh J, Ameer GA. Biomaterials. 2006; 27:5845.

  • Yang J, Webb AR, Hageman G, Ameer GA. Adv Mater. 2004; 16:511.

  • Yang J, Motlagh D, Webb AR, Ameer GA. Tissue Eng. 2005; 11:1876.

  • Dey J, Xu H, Shen JH, Thevenot P, Gondi SR, Nguyen KT, Sumerlin BS, Tang LP, Yang J.Biomaterials. 2008; 29:4637.

  • Yang J, Zhang Y, Gautam S, Liu L, Dey J, Chen W, Mason RP, Serrano CA, Schug KA, Tang L. Proc Natl Acad Sci USA. 2009; 106:10086.

  • Bruggeman JP, Bettinger CJ, Nijst CLE, Kohane DS, Langer R. Adv Mater. 2008; 20:1922.

  • Amoa K. J Chem Edu 2007; 84:1948.

  • Daruwalla J, Greish K, Malcontenti-Wilson C, Muralidharan V, Iyer A, Maeda H, et al. SJ Vasc Res 2008; 46(3):218-28.

  • Bettinger CJ, Bruggeman JP, Borenstein JT, Langer RS. Biomaterials 2008; 29(15): 2315-25.

  • Wong TW, Wahab S, Anthony Y. Int J Pharm 2008; 3571(1- 2):154-63.

  • Cerbai, B.; Solaro, R.; Chiellini, E. J. Polym. Sci., Part A: Polym Chem 2008; 46:2459–2476.

  • Barrera, D. A.; Zylstra, E.; Lansbury, P. T.; Langer, R. J. Am. Chem. Soc. 1993, 115, 11010–11021.

  • Djordjevic I; Choudhury N.R; Dutta N.K; Kumar S; Polymer 2009; 50:1682- 1691.

  • Kaihara S, Matsumura S, Fisher JP. Eur J Pharm Biopharm 2008; 68:67.

  • Behravesh E, Shung AK, Jo S, Mikos AG. Biomacromolecules 2002; 3:153.


Abstract Views: 367

PDF Views: 2




  • Synthesis and Characterization of Novel Bio-Elastomers for Tissue Engineering

Abstract Views: 367  |  PDF Views: 2

Authors

R Indira
PG and Research Department of Chemistry, Presidency College, Chennai – 600 005
G Harihara Priya
PG and Research Department of Chemistry, Presidency College, Chennai – 600 005
T Tamizharuvi
PG and Research Department of Chemistry, Presidency College, Chennai – 600 005
V Jaisankar
PG and Research Department of Chemistry, Presidency College, Chennai – 600 005

Abstract


Biodegradable elastomers have recently found widespread application in many areas of biomedical engineering such as tissue engineering, therapeutic delivery and bioimaging. Recent developments led to development of elastomers involving citric acid based polyesters are being explored that are endogenous to the human metabolism. In terms of mechanical stability, crystallinity, hydrophobicity and biocompatibility, polyesters synthesised from these monomers can display a wide range of applications. In this investigation, a series of novel bio-elastomers based on citric acid were synthesised by catalyst free polycondensation reaction. These polymers were characterised by solubility, IR, 1H NMR spectral analysis, thermal and mechanical studies. The physicochemical properties of the synthesised polymers are controlled by the variation of monomers in polycondensation reaction forms a pivotal role in the synthesis.

Keywords


Biodegradable Elastomers, Biocompatibility, Polycondensation, Spectral Analysis

References