Asian Journal of Research in Chemistry

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Synthesis, Characterization and Antibacterial Screening of Azo Compounds Containing Vanillin Moiety


Affiliations
1 Department of Chemistry, R. A. Arts, M. K. Commerce and Shri. S. R. Rathi Science College, Washim.444505, India
2 Matoshree Subhadrabai Patil Arts, Science and Late P.T .Commerce College, Manora, Dist-Washim
     

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In this study, a series of azo compounds were synthesized in excellent yields via the diazotization of different aromatic amines followed by coupling with vanillin. These compounds were characterized by elemental analysis, IR, 1HNMR spectral techniques. The synthesized compounds have been tested in vitro against human pathogens in order to assess their antibacterial properties using disk diffusion method. The compounds analysed for its antibacterial action showed inhibitory effect at all concentrations against all the test pathogens.

Keywords

Vanillin, Azo Compounds, Antibacterial Activity, Human Pathogens
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  • Wainwright M.. J. Antimicrob. Chem : Vol. 47, (2001)1.

  • Klink S.I., Alink P.O., Grave L., Peters F.G.A., Hofstraat J.W., Geurts F., Van Veggel, and F.C.J.M., J. Chem. Soc.: Perkin Trans: Vol. 2, (2001) 363-372.

  • Gong G., Gao X., Wang J., Zhao D.and Freeman H. S. Dyes Pigments: Vol. 53, (2002) 109-117.

  • Hinks D., Freeman H. S., Nakpathom M. and Sokolowska J. Dyes Pigments: Vol. 44, (2000) 199-207.

  • Wojciechowski K., Wyrebak A. and Gumulak JDyes Pigments: Vol. 56, (2003). 99-109.

  • Wojciechowski K. and Gumulak J.Dyes Pigments: Vol. 56, (2003) 195-202.

  • Rudyk H., Knaggs M.H., Vasiljevic S., Hope J., Birkett C. and Gilbert I.H. Eur J. of Med.Chem: Vol. 38, (2003) 567-579.

  • Pielesz A., Baranowska I., Rybak A. and Wlochowicz A., Ecotoxicology and environmental safety: Vol. 53, (2002) 42.

  • Mittal A., Kurup L. and Mittal J. Journal of Hazardous Materials: Vol. 146, (2007) 243-248.

  • Wainwright M., Dyes and Pigments: Vol. 76, (2008) 582-589.

  • Ahmed A.E.I., Hay J.N., Bushell, M.E., Wardell, J.N. and Cavalli G. Reactive and

  • Functional Polymers: Vol. 68, (2008) 248-260.

  • Simu G., Chicu S. A., Morin N., Schmidt W. and Sisu E.Turk. J. Chem: Vol. 28, (2004) 579.

  • Simu G., Funar-Timofei S., Hora S., Schmidt W., Kurunczi L., Sisu E. and Morin N. Rev.Chim.-Bucharest: Vol.53, (2002) 826.

  • Simu G. M., Hora S. G., Grad M. E. and Sisu E. N. V., Rev. Roum. Chim: Vol. 50(2), (2005) 113.

  • Bae J.-S., Freeman H. S., El-Shafei A., Dyes and Pigments: Vol. 57, (2003) 121.

  • Sanjay F. T., Dinesh M. P., Manish P. P., Ranjan G. P., Saudi Pharmaceutical Journal: Vol. 15(1), (2007) 48-54.

  • Child, R.G., Wilkinson, R.G. and Tomcu-Fucik A., Chem. Abstr. : Vol. 87, (1977) 6031.

  • Garg, H.G. and Praksh, C. J. Med. Chem: Vol. 15(4), (1972) 435- 436.

  • Browing, C.H., Cohen, J.B., Ellingworth, S. and Gulbransen R. Journal Storage: Vol. 100, (1926) 293-325

  • Rajendra N. Goyal, Madhu S. Verma, and Naveen K. Singhal Croatica chemica acta: Vol. 71 (3) (1998) 715-726.

  • Fatma Karipcin and Eser Kabalcilar Acta Chim. Slov: Vol. 54, (2007) 242–247.

  • K.M.Rathod Oriental Journal of Chemistry, vol 26(3) (2010) 1163-1166.

  • K.M.Rathod, Asian Journal of Research in Chemistry, vol.4 (5) (2011) 734-736.

  • G. Pandey and K.K. Narang. Bioinorganic Chemistry and Applications: Vol. 3, (2005) 217-238.

  • A.V. Patel E-journal of chemistry: Vol. 6(4), (2009) 1247-1252.

  • Chatwal G R Synthetic drugs,(Himalaya Publishing house),1996,331

  • Goksu S, Uguz M.T, Ozdemir H and Secen H.A, Truk J. Chem, 29, (2005)199-205.


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  • Synthesis, Characterization and Antibacterial Screening of Azo Compounds Containing Vanillin Moiety

Abstract Views: 405  |  PDF Views: 4

Authors

R. F. Pagariya
Department of Chemistry, R. A. Arts, M. K. Commerce and Shri. S. R. Rathi Science College, Washim.444505, India
K.M. Rathod
Department of Chemistry, R. A. Arts, M. K. Commerce and Shri. S. R. Rathi Science College, Washim.444505, India
N. S. Thakre
Matoshree Subhadrabai Patil Arts, Science and Late P.T .Commerce College, Manora, Dist-Washim

Abstract


In this study, a series of azo compounds were synthesized in excellent yields via the diazotization of different aromatic amines followed by coupling with vanillin. These compounds were characterized by elemental analysis, IR, 1HNMR spectral techniques. The synthesized compounds have been tested in vitro against human pathogens in order to assess their antibacterial properties using disk diffusion method. The compounds analysed for its antibacterial action showed inhibitory effect at all concentrations against all the test pathogens.

Keywords


Vanillin, Azo Compounds, Antibacterial Activity, Human Pathogens

References