Asian Journal of Research in Chemistry

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Demethylation of Mitragynine Picrate with BBr3 and C12H25-SH /NaOMe: A new entry for Ester Derivatives Preparation based on Position Carbon 9


Affiliations
1 Centre for Drug Research, Universiti Sains Malaysia, Penang 11800, Malaysia
     

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An efficient and simple one pot method for the conversion of mitragynine picrate to 9-hydroxycorynantheidine picrate was investigated for yields, selectivity and conversion in comparisons with the CYP2D6 enzyme. By applying this particular version of procedure, preparation of various ester derivatives based on position carbon 9 will be investigated.

Keywords

Mitragynine Picrate, 9-Hydroxycorynantheidine, Yields, Conversion, Selectivity
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  • Beckett, A.H.; Morton, D.M. Biochemical Pharmacol. 1967, 16 (8), 1609-1615.

  • Maurer, H.H.; Philipp, A.A.; Wissenbach, D.K.; Klein, O.N.; Zoerntlein, S.W. J. Mass. Spectrom. 2009, 44, 1249-1261.

  • Takayama, H.; Aimi, N.; Sakai, S. Yakugaku Zasshi 2000, 120, 959-967.

  • Takayama, H.; Ishikawa, H.; Kurihara, M.; Kitajima, M.; Aimi, N.; Ponglux, D.; Murayama, T.; Horie, S. J. Med. Chem. 2002, 45, 1949-1956.

  • Manabu, N.; Kamal, K.; Kiyoharu, N.; Shin-ichi, O.; Tetsuo, M. Tetrahedron Lett. 2001, 42(52), 9207-9210.

  • Lisa,F.F; Karen,M.M; Cheng-yi, C; Debra, J.W; Jerry, A.M; Lushi, T; Weirong, C; Edward, J.J. Tetrahedron, 2003, 59(33), 6363-6373.

  • McOmie, J.F.W.; Watts, M.L.; West, D.E. Tetrahedron. 1968, 24, 2289-2292.

  • McOmie, J.F.W.; Watts, M.L. Chem. Ind. (London), 1963, 1658.

  • Benton, F.L.; Dillon, T.E. J. Am. Chem. Soc. 1942, 64, 1128.

  • Drury, C. Tetrahedron. 2001, 57 (14), 2643-2684.


Abstract Views: 351

PDF Views: 2




  • Demethylation of Mitragynine Picrate with BBr3 and C12H25-SH /NaOMe: A new entry for Ester Derivatives Preparation based on Position Carbon 9

Abstract Views: 351  |  PDF Views: 2

Authors

T.B. Goh
Centre for Drug Research, Universiti Sains Malaysia, Penang 11800, Malaysia
M.M. Mordi
Centre for Drug Research, Universiti Sains Malaysia, Penang 11800, Malaysia
S.M. Mansor
Centre for Drug Research, Universiti Sains Malaysia, Penang 11800, Malaysia

Abstract


An efficient and simple one pot method for the conversion of mitragynine picrate to 9-hydroxycorynantheidine picrate was investigated for yields, selectivity and conversion in comparisons with the CYP2D6 enzyme. By applying this particular version of procedure, preparation of various ester derivatives based on position carbon 9 will be investigated.

Keywords


Mitragynine Picrate, 9-Hydroxycorynantheidine, Yields, Conversion, Selectivity

References