Asian Journal of Research in Chemistry

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A Review on 1,3-Thiazolidin-4-Ones


Affiliations
1 Department of Pharmaceutical Chemistry, Annamacharya College of Pharmacy, New Boyanapalli, Kadapa (District), Andhra Pradesh
2 Head of the Department, Department of Pharmaceutical Chemistry, Annamacharya College of Pharmacy, New Boyanapalli, Kadapa (District), Andhra Pradesh
     

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1,3-Thiazolidin-4-ones are important group of heterocyclic compounds that are used in the field of medicinal chemistry. The utility of 1,3-thiazolidin-4-ones as synthons for various biological compounds has given impetus to these studies. This review aims to review the work reported on the chemistry and biological activities of 1,3- thiazolidin-4-ones during the past few years. Since a decade extensive research work is undergoing on the thiazolidine ring. Researchers have developed number of new compounds related to1,3-thiazolidin-4-ones further they have screened them for various pharmacological activities to get a molecule with good pharmacological activities and with least adverse effects. The thiazolidine is not only synthetically important scaffold but also possesses a wide range of promising biological activities. Some thiazolidine derivatives have better activity than standard drug and could become a new drug for the market in future. This thiazolidine moiety and its derivatives has shown its importance as antimicrobial, anti-bacterial, anti-tubercular, anti-fungal, anti-inflammatory, analgesic, anti-cancer, anti-proliferative, anti- HIV, anti-retroviral,anti-yellowfevervirus,anti-diarrhoeal,anti-arrythmic agent, anti-convulsant, anti-oxidant, antimalarial.

Keywords

Thiazolidinone, Biological Activities, Anti-microbial, Anti-malarial, Future Aspect
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  • A Review on 1,3-Thiazolidin-4-Ones

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Authors

Kencha Swathi
Department of Pharmaceutical Chemistry, Annamacharya College of Pharmacy, New Boyanapalli, Kadapa (District), Andhra Pradesh
M. Sreenivasulu
Head of the Department, Department of Pharmaceutical Chemistry, Annamacharya College of Pharmacy, New Boyanapalli, Kadapa (District), Andhra Pradesh
T. Hari Narayana Reddy
Department of Pharmaceutical Chemistry, Annamacharya College of Pharmacy, New Boyanapalli, Kadapa (District), Andhra Pradesh
Y. Pradeep Kumar
Department of Pharmaceutical Chemistry, Annamacharya College of Pharmacy, New Boyanapalli, Kadapa (District), Andhra Pradesh
G. Mahaboob Basha
Department of Pharmaceutical Chemistry, Annamacharya College of Pharmacy, New Boyanapalli, Kadapa (District), Andhra Pradesh

Abstract


1,3-Thiazolidin-4-ones are important group of heterocyclic compounds that are used in the field of medicinal chemistry. The utility of 1,3-thiazolidin-4-ones as synthons for various biological compounds has given impetus to these studies. This review aims to review the work reported on the chemistry and biological activities of 1,3- thiazolidin-4-ones during the past few years. Since a decade extensive research work is undergoing on the thiazolidine ring. Researchers have developed number of new compounds related to1,3-thiazolidin-4-ones further they have screened them for various pharmacological activities to get a molecule with good pharmacological activities and with least adverse effects. The thiazolidine is not only synthetically important scaffold but also possesses a wide range of promising biological activities. Some thiazolidine derivatives have better activity than standard drug and could become a new drug for the market in future. This thiazolidine moiety and its derivatives has shown its importance as antimicrobial, anti-bacterial, anti-tubercular, anti-fungal, anti-inflammatory, analgesic, anti-cancer, anti-proliferative, anti- HIV, anti-retroviral,anti-yellowfevervirus,anti-diarrhoeal,anti-arrythmic agent, anti-convulsant, anti-oxidant, antimalarial.

Keywords


Thiazolidinone, Biological Activities, Anti-microbial, Anti-malarial, Future Aspect

References