Formulation and Evaluation of Zidovudine Loaded Microsphere

In the present study a satisfactory attempt was made to develop microparticulate drug delivery system of zidovudine with improved bioavailability, efficient targeting and dose reduction. From the experimental results demonstrated that Chitosan polymer is a suitable macromolecule for the preparation of microspheres of Zidovudine. Particle size analysis revealed that the microspheres were in the range (172 to 192μm) and all the formulations showed ideal surface methodology. Present study shows that the targeting efficiency of drug loaded microspheres over free drug was higher which may provide increased therapeutic efficacy.