Pharmaceutical Co-Crystallization

Co-crystal consists of API and a stoichiometric amount of a pharmaceutically acceptable co-crystal former. Pharmaceutical Co-crystal is non-ionic supramolecular complexes and can be used to address physical property issues such as solubility, stability and bioavailability in pharmaceutical development without changing the chemical composition of the API. Co-crystal is a crystalline entity formed by two different or more molecular entities where the intermolecular interactions are weak forces like hydrogen bonding and π-π stacking. Super porous systems, biodegradable hydrogel systems. Co crystallization alters the molecular interaction and composition of pharmaceutical materials, and is considered better alternative to optimize drug properties. The article gives brief review on the co-crystallization, selection of appropriate co former and preparation of co crystals, different techniques of co-crystallization, physicochemical properties, characterization and applications.