Asian Journal of Research in Pharmaceutical Sciences

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Synthesis and Evaluation of Antioxidant Activities of Some Novel Isatin Derivatives and Analogs


Affiliations
1 Department of Pharmaceutical Chemistry, DCRM Pharmacy College, Inkollu. Andhra Pradesh, India
2 Department of Pharmaceutical Chemistry, DCRM Pharmacy College, Inkollu, Andhra Pradesh, India
3 Medicinal Chemistry Research Laboratory, Bapatla College of Pharmacy, Bapatla-522 101, (A.P), India
4 Dep. of Pharmaceutics, Rahul Institute of Pharmaceutical Science and Research, Chirala-523157, (A.P.), India
5 Department Pharmaceutical Chemistry, Srinivas College of Pharmacy, Mangalore-574142, Karnataka, India
     

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In the present study, a series of novel Schiff bases of isatin were synthesized by condensation of imesatin with different aromatic aldehydes. The imesatins were synthesized by reaction of isatin with p-phenylenediamine. The chemical structures of the synthesized compounds were confirmed by means of IR, 1H-NMR, mass spectroscopy, and elemental analysis. These compounds were screened for antioxidant activity by DPPH radical scavenging activity. In this method, the compound 3-(4-(4-dimethylaminobenzylideneamino) phenylimino) indoline-2-one (5c) showed highest antioxidant activity because of the presence of electron donating group.

Keywords

Antioxidant, Isatin, Schiff Base.
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  • Synthesis and Evaluation of Antioxidant Activities of Some Novel Isatin Derivatives and Analogs

Abstract Views: 244  |  PDF Views: 0

Authors

C. R. Prakash
Department of Pharmaceutical Chemistry, DCRM Pharmacy College, Inkollu. Andhra Pradesh, India
S. Raja
Department of Pharmaceutical Chemistry, DCRM Pharmacy College, Inkollu, Andhra Pradesh, India
G. Saravanan
Medicinal Chemistry Research Laboratory, Bapatla College of Pharmacy, Bapatla-522 101, (A.P), India
P. Dinesh Kumar
Dep. of Pharmaceutics, Rahul Institute of Pharmaceutical Science and Research, Chirala-523157, (A.P.), India
T. Panneer Selvam
Department Pharmaceutical Chemistry, Srinivas College of Pharmacy, Mangalore-574142, Karnataka, India

Abstract


In the present study, a series of novel Schiff bases of isatin were synthesized by condensation of imesatin with different aromatic aldehydes. The imesatins were synthesized by reaction of isatin with p-phenylenediamine. The chemical structures of the synthesized compounds were confirmed by means of IR, 1H-NMR, mass spectroscopy, and elemental analysis. These compounds were screened for antioxidant activity by DPPH radical scavenging activity. In this method, the compound 3-(4-(4-dimethylaminobenzylideneamino) phenylimino) indoline-2-one (5c) showed highest antioxidant activity because of the presence of electron donating group.

Keywords


Antioxidant, Isatin, Schiff Base.