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Nanosuspension:An Overview


Affiliations
1 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, India
2 Department of Quality Assurance Techniques, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, India
     

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Nanosuspensions are important carriers to develop novel drug formulations. Nanosuspensions have emerged as a promising strategy for the efficient delivery of hydrophobic drugs because of their versatile features and unique advantages. Nanosuspension technology solved the problem of drugs which are poorly aqueous soluble and less bioavailability. Stability and bioavailability of the drugs can be improved by the Nanosuspension technology. Techniques such as media milling and high pressure homogenization have been used commercially for producing nanosuspensions. Nanosuspensions can be delivered by oral, parenteral, pulmonary and ocular routes.Nanosuspensions can also be used for targeted drug delivery when incorporated in the Ocular inserts and mucoadhesive hydrogels. Currently, efforts are being directed to extending their applications in site-specific drug delivery.

Keywords

Nanosuspension, Solubility Enhancement, Particle Size, Surfactant, Colloidal Dispersion, Oral Bioavailability.
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  • Nanosuspension:An Overview

Abstract Views: 335  |  PDF Views: 5

Authors

Smita S. Aher
Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, India
Sagar T. Malsane
Department of Quality Assurance Techniques, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, India
R. B. Saudagar
Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, India

Abstract


Nanosuspensions are important carriers to develop novel drug formulations. Nanosuspensions have emerged as a promising strategy for the efficient delivery of hydrophobic drugs because of their versatile features and unique advantages. Nanosuspension technology solved the problem of drugs which are poorly aqueous soluble and less bioavailability. Stability and bioavailability of the drugs can be improved by the Nanosuspension technology. Techniques such as media milling and high pressure homogenization have been used commercially for producing nanosuspensions. Nanosuspensions can be delivered by oral, parenteral, pulmonary and ocular routes.Nanosuspensions can also be used for targeted drug delivery when incorporated in the Ocular inserts and mucoadhesive hydrogels. Currently, efforts are being directed to extending their applications in site-specific drug delivery.

Keywords


Nanosuspension, Solubility Enhancement, Particle Size, Surfactant, Colloidal Dispersion, Oral Bioavailability.