Asian Journal of Research in Pharmaceutical Sciences

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Preparation and Evaluation of a Mucoadhesive Polymer from the Extract of Seeds of Annona squamosa Linn


Affiliations
1 Department of Pharmaceutics, Vishnu Institute of Pharmaceutical Education And Research, Vishnupur, Narsapur, Medak, Telangana, India
2 Department of Pharmaceutics, Vinayaka Mission’s College of pharmacy Vishnupur, salem, Tamilnadu, India
3 Department of Pharmaceutics, Vishnu Institute of Pharmaceutical Education and Research, Vishnupur, Narsapur, Medak, Telangana, India
4 Department of Pharmacology, Vishnu Institute of Pharmaceutical Education and Research, Vishnupur, Narsapur, Medak, Telangana, India
     

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Mucoadhesive drug delivery systems exploit the attraction between the mucus and polymeric drug carriers. They provide localization of the carriers within the specific body site and prolonged residence time of delivery devices. In this present work an attempt was made to isolate a mucoadhesive polymer from an indigenous plant Annona squamosa Linn and characterize its mucoadhesive properties. The results of the present investigation revealed that the prepared polymer characterized as a mucoadhesive polymer as compared with the available polymers. It shows best results in evaluation processes by shear stress, tensile strength, shear strength, falling sphere, swelling factor, viscosity, stability studies.

Keywords

Preparation of a Mucoadhesive Polymer, Preparation of a Mucoadhesive Polymer from the Extract of Seeds, Annona squamosa Linn., Seeds of Annona squamosa Linn., Polymer from the Extract of Seeds of Annona squamosa Linn., Extract of Seeds of Annona squamosa Linn., Mucoadhesive Polymer, Mucoadhesive Polymer from the Extract.
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  • K. Santhi and R. Sengottu vel “Qualitative and Quantitative analysis of Moringa concanensis nimmo” Int. J. Curr.Microbiol. App. Sci (2016)5(1): 633-640

  • Mohammed Shaibu Auwal, Sanni Saka, Ismail Alhaji Mairiga, Kyari Abba Sanda, Abdullahi Shuaibu, Amina Ibrahim “Preliminary phytochemical and elemental analysis of aqueous and fractionated pod extracts of Acacia nilotica” Vet Res Forum.2014 spring; 5(2): 95–100.

  • Harbone, JB. Phytochemical Method Published by Jackman and Haulondon, 1973, P.90.

  • Madhusudan Rao.Y; Vani.G, Bala Ramesha Chary R, Indian drugs 1998, 35(9); 558-565.

  • B.P., 1993 Published on the Recommentation of the Medicians commission Pursuant to the Medicine Act 1968, volume II, a 157.

  • Manavalan R., Ramasamy C., Physical Pharmaceutics, Vignesh Publisher,1st edition,1995, 148 – 149.

  • Bernkop-Schnu¨ rch, A., S.T.P. Pharma Sci., 1999, 9, 78–87.

  • Smart, J.D, Kellaway. I.W. Worthing ton., H.E.C J. Pharm. Pharmacol., 1984, 36,295.

  • Lehr, C.M., Eur. J. Drug Metab. Pharmacokinet., 1996, 21, 139– 148.

  • Rajesh B.G., Robinson J.R. Ind. Journal Pharm. Sci., 1988, 50(3), 145-152.

  • Guo. J.H. Drug Dev. Ind. Pharm., 1994, 20, 2809.

  • Mikos A. G. Pepppas, M.A., Europhys Lett. 1988, 6, 403.

  • Park, H., and Robinson, J.R., J. control. Rel., 1985, 2, 47-57.

  • Teng, C.L.C Ho, N.F.L.J. Contr. Rel.1987, 6,133.

  • Chen J.L. Cyr.G.N. Adhesion in Biological systems., Academic press, 1970, 163-187.


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  • Preparation and Evaluation of a Mucoadhesive Polymer from the Extract of Seeds of Annona squamosa Linn

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Authors

M. Venkataswamy
Department of Pharmaceutics, Vishnu Institute of Pharmaceutical Education And Research, Vishnupur, Narsapur, Medak, Telangana, India
B. Arul
Department of Pharmaceutics, Vinayaka Mission’s College of pharmacy Vishnupur, salem, Tamilnadu, India
A. Keerthi Sagar
Department of Pharmaceutics, Vishnu Institute of Pharmaceutical Education and Research, Vishnupur, Narsapur, Medak, Telangana, India
S. Dinesh Mohan
Department of Pharmaceutics, Vishnu Institute of Pharmaceutical Education and Research, Vishnupur, Narsapur, Medak, Telangana, India
K. Vanitha
Department of Pharmaceutics, Vishnu Institute of Pharmaceutical Education and Research, Vishnupur, Narsapur, Medak, Telangana, India
Ramesh Alluri
Department of Pharmacology, Vishnu Institute of Pharmaceutical Education and Research, Vishnupur, Narsapur, Medak, Telangana, India

Abstract


Mucoadhesive drug delivery systems exploit the attraction between the mucus and polymeric drug carriers. They provide localization of the carriers within the specific body site and prolonged residence time of delivery devices. In this present work an attempt was made to isolate a mucoadhesive polymer from an indigenous plant Annona squamosa Linn and characterize its mucoadhesive properties. The results of the present investigation revealed that the prepared polymer characterized as a mucoadhesive polymer as compared with the available polymers. It shows best results in evaluation processes by shear stress, tensile strength, shear strength, falling sphere, swelling factor, viscosity, stability studies.

Keywords


Preparation of a Mucoadhesive Polymer, Preparation of a Mucoadhesive Polymer from the Extract of Seeds, Annona squamosa Linn., Seeds of Annona squamosa Linn., Polymer from the Extract of Seeds of Annona squamosa Linn., Extract of Seeds of Annona squamosa Linn., Mucoadhesive Polymer, Mucoadhesive Polymer from the Extract.

References