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Drug Delivery Systems Based on Polymeric Micelles
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Polymeric micelles have been extensively studied as nanocarriers for hydrophobic drugs. They can be designed to have the intensity of duration and blood circulation, as well as binding specificity to certain highly stressed receptors on the surface of cancer cells. y. The incorporation of these agents into nanoparticles reduces the adverse effects of standard chemotherapy on healthy tissues. Such nanoparticles, considered to be drug-transporting vehicles, are versatile and include micelles, liposomes, dendrimers, nanocapsules, nanospheres and more. Polymeric micelles have been extensively studied as nanocarriers for hydrophobic drugs. They can be designed to have the intensity of duration and circulation, as well as binding specifications to certain more receptors expressed on the surface of cancer cells. When these drug-induced nanoparticles reach the plant surface, an external stimulus, such as ultrasound, can be used to introduce local and temporary drug release.
Keywords
Cancer, Chemotherapy, Drug release, Polymeric micelles, Triggered release.
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- Mourya V. K., Inamdar Nazma, Nawale B.R., Kulthe S. S. Polymeric Micelles: General Considerations and their Applications. Indian Journal of Pharmaceutical Education and Research. 2011; 45
- Mathew Chinju, Sebastian Kripa, Daisy P. A, R. Praveen Raj. A Comprehensive Review on Polymeric Micelles, Inst. J. Pharm. Sci. Rev. Res. 2020; 61(2): 08,36-39, www.globalresearchonline.net
- Xu Wei, Ling Peixue, Zhang Tianmin. Review Article Polymeric Micelles, a Promising Drug Delivery System to Enhance Bioavailability of Poorly Water-Soluble Drugs, Hindawi Publishing Corporation Journal of Drug Delivery. 2013, Article ID 340315, 15 pages.
- Nagaich Upendra, Deepak Payal, Sharma Aman, Gulati Neha, Chaudhary Amit. Review Article polymeric micelles: potential drug delivery devices. Indonesian J. Pharm. 2013; 24(4): 223 – 238
- Wakaskar Rajesh R, Polymeric Micelles and their Properties, Article in Journal of Nanomedicine and Nanotechnology, January 2017.
- Kulthe Sushant S., Choudhury Yogesh M., Inamdar Nazma N., Mourya Vishnukant. Polymeric micelles: authoritative aspects for drug delivery. Designed Monomers and Polymers. 2012; 15(5): 465–521.
- Powar Priyatama V, Sharma Padmini H. Review article on Polymeric micelle as multifunctional therapeutics. Journal of Innovations in Applied Pharmaceutical Science. 2016; 1 (1): 24-33.
- Elena V. Batrakova, Tatiana K. Bronich, Joseph A. Vetro and Alexander V. Kabanov. Ordanini Stefania and Cellesi Francesco. Complex Polymeric Architectures Self-Assembling in Unimolecular Micelles: Preparation, Characterization, and Drug Nanoencapsulation. Pharmaceutics. 2018; 10: 209.
- Salimi Anayatollah, Zadeh Behzad Sharif Makhmal, Mahmoudabadi Najme. Formulation and evaluation of polymeric micelle drug delivery system of celecoxib to improve the oral absorption. European Journal of Biomedical and Pharmaceutical Sciences. EJBPS. 2014; 1(2): 372-385.
- Suroshe Samiksha, Nerkar Pankaj, Patil Kanchan, Chalikwar Shailesh. Breast cancer: Recent review on micelles as nano-carriers for treatment. Indo American Journal of Pharmaceutical Research. 2019.
- Zana R. Dynamics of surfactant self-assemblies-Micelles, microemulsions, vesicles, and lyotropic Phases. Boca Raton, FL33487-2742: CRC Press, Taylor and Francis Group; 2005. Pp. 2-16.
- Mahmud A, Xiong XB, Aliabadi HM, Lavasanifar A. Polymeric micelles for drug targeting. J Drug Target 2007; 15:553-84.
- Adams ML, Lavasanifar A. Kwon GS. Mini review Amphiphilic block copolymers for drug delivery. J. Pharm. Sci. 92, 2003, 1343−1355.
- Rubetskoy VS. Polymeric micelles as carriers of diagnostic agents. Adv Drug Deliv Rev. 37, 1999, 81-88.
- Nangare K A, Powar S D, Kate V K, Nandgude T D, Payghan S A. Exploring the State-of-Art of Nanosuspensions: Theoretical Aspects, Formulation and Characterization. Inventi: PNDDS/25746/18.
- L. Bromberg. Polymeric micelles in oral chemotherapy. Journal of Controlled Release. 2008; 128(2): 99–112.
- L. Bromberg, M. Temchenko, V. Alakhov, and T. A. Hatton. Bioadhesive properties and rheology of polyether-modified Poly(acrylic acid) hydrogels. International Journal of Pharmaceutics. 2004; 282(1-2): 45–60.
- Sarda Akash, Powar Sayali, Nangare Kavita, Payghan S A. Formulation and Characterization of Sublingual Tablet for Rapid Absorption and Taste Masking of Tenoxicam. Inventi Rapid: Pharm Tech. 2017; (1):1-14.
- Adams ML., Lavasanifar A. Kwon GS. Minireview amphiphilic block copolymers for drug delivery. J. Pharm. Sci. 2003; 92: 1343−1355.
- Dhembre GN., Moon RS., Kshirsagar RV. A review on polymeric micellar Nanocarriers. IJPBS. 2011; 2: 109-116.
- Nangare K A, Powar S D, Kate V K, Nandgude T D, Payghan S A., Exploring the State-of-Art of Nanosuspensions: Theoretical Aspects, Formulation and Characterization. Inventi: PNDDS/25746/18.
- Jones MC, Leroux JC. Polymeric micelles a new generation of colloidal drug carriers. European Journal of Pharmaceutics and Biopharmaceutics. 1999; 48:101–11.
- K. A. Nangare, S. D. Powar, S. A. Payghan: Nanoerythrosomes: Engineered Erythrocytes as a Novel Carrier for the Targeted Drug Delivery. Asian Journal of Pharmaceutics. 2016; 10 (3):223-233.
- Nangare Kavita, Powar Sayali, Santosh Ambadas Payghan. Design of Three-factor Response Surface Optimization of Camouflaged Capecitabine Nanoerythrovesicles. Asian Journal of Pharmaceutics 2016; 10 (4): 306-321.
- Swapnil Chopade, Sheeba Khabade, Kavita Nangare, Powar Sayali, Bagal Vinay. Box–Behnken design for preparation of Tenoxicam- nanogel for ocular delivery: Optimization, in vitro Coneal permeation. 2018; 9(4):486-499.
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