Asian Journal of Research in Pharmaceutical Sciences

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

A Review on Magnetic Microspheres- A Novel Drug Delivery System


Affiliations
1 Department of Pharmaceutics, P. R. Pote Patil College of Pharmacy, Amravati., India
     

   Subscribe/Renew Journal


Magnetic microspheres as an alternative to conventional radiation methods which use extremely penetrating radiation that is absorbed throughout the body. Its use is limited by toxicity and side effects. The aim of the specific targeting is to enhance the efficiency of drug delivery and at the same time to decrease the toxicity and side effects. One of its important applications is that it is used for targeting tumors using anticancer drugs. Being more stable, it has an advantage over other delivery systems like liposome. The main objectives of this review are to highlight some important aspects of magnetic microspheres as a novel drug delivery system. The review shall cover definitions, concepts, types, mechanism of targeting, evaluation and characteristics of magnetic microspheres as well as various methods and techniques used in their preparations. The review also entails various applications and future prospects of magnetic microspheres

Keywords

Magnetic Microspheres, Preparation, Evaluation, Novel Drug Delivery.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Widder, D.J., Greif, W.L., Widder, K.J., Edelman, R.R., Brady, T.J. (1987), Magnetite albumin microspheres: a new MR contrast material, AJR, Am J Roentgenol, 148 (2), 399-404.

  • Alexiou, C., Arnold, W., Hulin, P., Klein, R.J., Renz, H., Parak, F.G., Christian, B.L., Stephans. A. (2001), Magnetic mitoxantrone nanoparticle detection by histology, X-ray and MRI after magnetic tumor targeting, J Mage Magn Mater, 225(1-2), 187-93.

  • Alagusundaram, M., Chetty, M.S.C., Umashankari, K., Badarinath, A.V., Lavanya, C., Ramkanth, S. (2009), Microspheres as a novel drug delivery system- a review, Int J Chem Tech Res, 1, 526-3.

  • Shankar NB, Kumar NU, Balakrishna PK, Kumar RP. Preparation and in vitro evaluation of lamivudine entrapped MOI microspheres for oral administration. Research Journal of Pharmacy and Technology. 2008;1(4):437-40.

  • Freeman, M.W., Arrott, A., Watson, J.H.L. (1960), Magnetism in medicine, J Appl Phys, 31(5), S404– S405.

  • Deshmukh VN, Jadhav JK, Masirkar VJ, Sakarkar DM. Formulation, optimization and evaluation of controlled release alginate microspheres using synergy gum blends. Research Journal of Pharmacy and Technology. 2009;2(2):324-7.

  • Malviya V. Preparation and Evaluation of Emulsomes as a Drug Delivery System for Bifonazole. Indian Journal of Pharmaceutical Education and Research. 2021 Jan 1;55(1):86-94.

  • Nakamura, T., Konno, K., Moroné, T., Tsuya, N., Hatano, M. (1971), Magneto-medicine: biological aspects of ferromagnetic fine particles, J Appl Phys, 42(4), 1320–1324.

  • Ovadia, H., Paterson, PY., Hale, JR. (1983). Magnetic microspheres as drug carriers: Factors influencing localization at different anatomical sites in rats, Isr J Med Sci, 19(7), 631–637.

  • Ishii, F., Takamura, A., Noro S. (1984), Magnetic microcapsules for in vitro testing as carrier for intravascular administration of anticancer drugs: preparation and physicochemical properties, Chem Pharm Bull, 32(2), 678–684.

  • Malviya V, Ladhake V, Gajbiye K, Satao J, Tawar M. Design and Characterization of Phase Transition System of Zolmitriptan Hydrochloride for Nasal Drug Delivery System. International Journal of Pharmaceutical Sciences and Nanotechnology. 2020 May 31;13(3):4942-51.

  • Goodwin, S.C., Bittner, C.A., Peterson, C.L., Wong, G. (2001), Single-dose toxicity study of hepatic intra-arterial infusion of doxorubicin coupled to a novel magnetically targeted drug carrier, Toxicol Sci, 60(1), 177–183.

  • Lubbe, A.S., Bergemann, C., Huhnt, W., Fricke, T., Riess, H., Brock, J.W., Huhn, D. (1996), Preclinical experiences with magnetic drug targeting: tolerance and efficacy, Cancer Res, 56(20), 4694–4701.

  • Lubbe, A.S., Bergemann, C., Riess, H., Schriever, F., Reichardt, P., Possinger, K., Matthias, M., Dörken, B., Herrmann, F., Gürtler, R., Hohenberger, P., Haas, N., Sohr, R., Sander, B., Lemke Margolis, L.B., Namiot, V.A., Kljkin, L.M. (1983), Biochim Biophysic Acta, 735, 193.

  • Malviya V, Manekar S. Design, Development and Evaluation of Aceclofenac and Curcumin Agglomerates by Crystallo Co-Agglomeration Technique. Research Journal of Pharmacy and Technology. 2021 Mar 1;14(3):1535-41.

  • Kavita Kunchu, Raje Veera Ashwaniet al. Albumin Microspheres: A unique system as drug delivery carriers for non-steroidal anti-inflammatory drugs. 2010; 5: 12.

  • Gallo JM, Gupta PK, Hung CT, Prrier DG. Magnetic particles for drug delivery. J Pharm Sci 1989; 78: 190.

  • Ishida M, Nambu N, Nagai T. Highly viscous gel ointment containing carbopol for application to oral mucosa. Chem Pharm Bull 1983; 31: 45-61.

  • Saravanakumar A, Minz S, Pradhan M, Sure P, Chandu AN, Mishra U, Kamalakannan K, Sivakumar T. Polylactic acid microspheres as a potential vaccine delivery system for the tetanus toxoid: Preparation and in vitro dissolution study. Research Journal of Pharmacy and Technology. 2008;1(4):453-9.

  • Malviya VR, Pande SD. Road CKN. Preparation ad Evaluation of Zolmitriptan Hydrochloride Lozenge. J Pharma Res. 2019;8(8):624-9.

  • Lachman LA, Liberman HA, Kanig JL. The theory and practice of industrial pharmacy. Mumbai, India: Varghese Publishing House; 2002, p. 414-415.

  • Kumar RP, Amitava G, Kumar NU, Shankar NB. Formulation Design, Preparation of Losartan Potassium Microspheres by W/O Emulsion Solvent Evaporation Method and It's In Vitro Characterization. Research Journal of Pharmacy and Technology. 2009;2(3):513-6.

  • Nasra MK, Mohamed MM, Elblbesy MA, Hefney BA. Preparation of biocompatible magnetic microspheres with chitosan. J Biomater Nanobiotechnol. 2011; 2: 194-200.

  • Malviya VR, Pande SD, Bobade NN. Preparation and Evaluation of Sustained Release Beads of Zolmitriptan Hydrochloride. Research Journal of Pharmacy and Technology. 2019; 12(12): 5972-6.

  • Wang K, Xing JF, Li XY, Fua Q, Li WF. Fabrication of novel magnetic nanoparticles-coated P(styrene-itaconic aciddivinylbenzene) microspheres. Carbohydr Polym. 2012; 87: 2712-2717.

  • Palanisamy M, Khanam J, Kumar NA, Rani C. Chitosan microspheres encapsulated with metoprolol succinate: formulation and in-vitro evaluation. Research Journal of Pharmacy and Technology. 2009; 2(2): 349-52.

  • Nighute AB, Bhise SB. Preparation and evaluation of rifabutin loaded polymeric microspheres. Research Journal of Pharmacy and Technology. 2009; 2(2): 371-4.

  • Ghosh A, Nayak UK, Rout P, Nag T, Roy P. Preparation, Evaluation and in vitro-in vivo Correlation (IVIVC) study of Lamivudine Loaded Microspheres. Research Journal of Pharmacy and Technology. 2008; 1(4): 353-6.

  • Shaji J, Shinde A. Formulation and evaluation of floating pulsatile microspheres of aceclofenac for rheumatoid arthritis. Research Journal of Pharmacy and Technology. 2011; 4(12): 1877-81.

  • Garg R, Gupta GD. Development and characterization of cellulose and Eudragit gastroretentive floating microspheres of acyclovir. Research Journal of Pharmacy and Technology. 2009; 2(1): 101-5.

  • Jiang W, Zhang XJ, Sun ZD, Fang Y, Li FS, Chen K, et al. Preparation and mechanism of magnetic carbonaceous polysaccharide microspheres by low-temperature hydrothermal method. J Magn Magn Mater. 2011; 323: 2741- 2747.

  • Hajare AA, Shetty YT. Formulation, characterization and in-vitro evaluation of floating microspheres of diltiazem hydrochloride by ionotropic gelation technique. Research Journal of Pharmacy and Technology. 2008; 1(1): 52-6.

  • Vyas and Khar. (2001), Targeted and Controlled drug delivery, CBS Publishers and Distributors.


Abstract Views: 66

PDF Views: 0




  • A Review on Magnetic Microspheres- A Novel Drug Delivery System

Abstract Views: 66  |  PDF Views: 0

Authors

Vishal Mahanur
Department of Pharmaceutics, P. R. Pote Patil College of Pharmacy, Amravati., India
Yash Sureka
Department of Pharmaceutics, P. R. Pote Patil College of Pharmacy, Amravati., India
Virendra Atole
Department of Pharmaceutics, P. R. Pote Patil College of Pharmacy, Amravati., India

Abstract


Magnetic microspheres as an alternative to conventional radiation methods which use extremely penetrating radiation that is absorbed throughout the body. Its use is limited by toxicity and side effects. The aim of the specific targeting is to enhance the efficiency of drug delivery and at the same time to decrease the toxicity and side effects. One of its important applications is that it is used for targeting tumors using anticancer drugs. Being more stable, it has an advantage over other delivery systems like liposome. The main objectives of this review are to highlight some important aspects of magnetic microspheres as a novel drug delivery system. The review shall cover definitions, concepts, types, mechanism of targeting, evaluation and characteristics of magnetic microspheres as well as various methods and techniques used in their preparations. The review also entails various applications and future prospects of magnetic microspheres

Keywords


Magnetic Microspheres, Preparation, Evaluation, Novel Drug Delivery.

References