Asian Journal of Research in Pharmaceutical Sciences

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Synthesis of Ethyl 2-(4-halobenzyl)-3-oxobutanoate and determination of its Biological activity by using prediction of activity spectra for substance


Affiliations
1 1Department of Pharmaceutical Chemistry, Dr. J. D Pawar College of Pharmacy, Kalwan, Nashik, Maharashtra, India
2 Department of Pharmaceutical Chemistry, MET’s Institute of Pharmacy, Adgaon, Nashik, Maharashtra, India
     

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In this study, Synthesis of ethyl 2-(4-halobenzyl)-3-oxobutanoate was carried out by using addition of substituted benzyl bromide to a suspension of t-BuOK (Potassium tert-butoxide) in THF (tetrahydrofuran). The reaction mixture was then refluxed for 12 hr. The progress of reaction was monitored using thin layer chromatography (TLC). Synthesize compound are characterized by elemental analysis and spectral analysis like infra red spectroscopy, nuclear magnetic spectroscopy and mass spectroscopy (IR,1H-NMR, MS). Pharmacological activity of these compound were predicted by individually using prediction of activity spectra for substance (PASS). It shows various pharmacological activities and mechanism of action such as L-glucuronate reductase inhibitor, Gluconate 2-dehydrogenase (acceptor) inhibitor, Centromere associated protein inhibitor, Eye irritation, inactive, GST A substrate, Pectate lyase inhibitor, 5-O-(4-coumaroyl)-D-quinate 3'-monooxygenase inhibitor, Acetylcholine neuromuscular blocking agent, Antihypoxic, Aspulvinone dimethylallyl transferase inhibitor.

Keywords

Substituted benzyl bromide; PASS, Probable activity, Probable Inactivity, Pharmacological activity.
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  • Synthesis of Ethyl 2-(4-halobenzyl)-3-oxobutanoate and determination of its Biological activity by using prediction of activity spectra for substance

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Authors

Kavita R Chandramore
1Department of Pharmaceutical Chemistry, Dr. J. D Pawar College of Pharmacy, Kalwan, Nashik, Maharashtra, India
Rohan S Ahire
Department of Pharmaceutical Chemistry, MET’s Institute of Pharmacy, Adgaon, Nashik, Maharashtra, India

Abstract


In this study, Synthesis of ethyl 2-(4-halobenzyl)-3-oxobutanoate was carried out by using addition of substituted benzyl bromide to a suspension of t-BuOK (Potassium tert-butoxide) in THF (tetrahydrofuran). The reaction mixture was then refluxed for 12 hr. The progress of reaction was monitored using thin layer chromatography (TLC). Synthesize compound are characterized by elemental analysis and spectral analysis like infra red spectroscopy, nuclear magnetic spectroscopy and mass spectroscopy (IR,1H-NMR, MS). Pharmacological activity of these compound were predicted by individually using prediction of activity spectra for substance (PASS). It shows various pharmacological activities and mechanism of action such as L-glucuronate reductase inhibitor, Gluconate 2-dehydrogenase (acceptor) inhibitor, Centromere associated protein inhibitor, Eye irritation, inactive, GST A substrate, Pectate lyase inhibitor, 5-O-(4-coumaroyl)-D-quinate 3'-monooxygenase inhibitor, Acetylcholine neuromuscular blocking agent, Antihypoxic, Aspulvinone dimethylallyl transferase inhibitor.

Keywords


Substituted benzyl bromide; PASS, Probable activity, Probable Inactivity, Pharmacological activity.

References