Asian Journal of Research in Pharmaceutical Sciences

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Enhancement of Solubility and Dissolution Rate of Poorly Water Soluble Drug by Using Modified Guar Gum


Affiliations
1 Dept. of Pharmaceutics, Saurashtra University, Rajkot -360005, India
     

   Subscribe/Renew Journal


Introduction: The increasing interest of the technology of dosage form with natural biopolymers has become the reason for undertaking present investigation on the possibility of guar gum application in the preparation of an oral solid dosage form of a poorly water soluble drug.

Method: Present study examines the effect of Guar gum (GG) and Modified guar gum (MGG) on the oral bioavailability of a poorly water-soluble drug, Ibuprofen (IBU). Modified guar gum (MGG) was prepared using heat treatment (125-130oC for 2 to 3 hours) method. It was characterized for viscosity, swelling index and water retention capacity. The physical and co-grinding mixtures of IBU with GG and MGG were prepared in 1:9 drug to gum ratio. The physical and co-grinding mixtures were characterized by DSC and FT-IR study.

Results: The studies confirmed that there was no interaction between drug and carrier. Prepared mixtures were evaluated for solubility study and in vitro dissolution studies using USP XXIII Dissolution apparatus. The rank order of solubility and dissolution study was IBU < grounded IBU < Physical mixture of IBU and GG < Physical mixture of IBU and MGG < Co-grinding mixture of IBU and GG < Co-grinding mixture of IBU and MGG.

Conclusion: The results of present investigation indicated that co-grinding mixture of ibuprofen with modified guar gum could be useful in developing an oral dosage form with improved dissolution and oral bioavailability of poorly water soluble drug.


Keywords

Guar Gum, Modified Guar Gum, Dissolution Rate Enhancement, Poorly Soluble Drug.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Ashford M. Bioavailability – physicochemical and dosage form factors. In Aulton ME, editor. Pharmaceutics-the design and manufacture of Medicines, 3rd ed. London: Churchill Livingstone ; 2007. p. 286-303.

  • Lipinski CA, Poor aqueous solubility-an industry wide problem in drug discovery. Am Pharm Rev 2002;5:82-85.

  • Noyes AA, Whitney WR. The rate of solution of solid substances in their own solutions. J Am Chem 1897;19:930-934.

  • Wadke DA, Serajuddin ATM, Jacobson H. Preformulation testing. In: Lieberman WA, Lachman L, Schwartz JB, editor. Pharmaceutical Dosage Forms: Tablets, 1st ed. New York :Marcel Dekker: 1989. p. 1–73.

  • Neva M, Bhandari KH. Enhancement of solubility, dissolution and bioavailability of ibuprofen by sold dispersion systems. Chem Pharm Bull 2001;56(4):569-574.

  • Whistler RL, Alter EN, Seaman JK. 1973. Industrial Gums: Polysaccharides and their Derivatives, 2nd ed. Academic Press, New York, London, p. 807.

  • Baveja JM, Misra AN, Modified Guar gum as a tablet disintigrant. Pharmazie 1997;52: 856-859.

  • Murli Mohan Babu GV, Prasad DS, Ramana Murthy KV. Evaluation of modified gum karaya as carrier for dissolution enhancement of poorly water soluble drug nimodipine. Int J Pharm 2002; 234:1-17.

  • Jain S, Yadav SK, Patil UK. Preparation and Evaluation of Sustained Release Matrix Tablet of Furosemide using Natural Polymers. Res J. Pharm.Tech. 2008;1(4):374-376.

  • Patel M, Tekade A, Gattani S, Surana S, Solubility Enhancement of Lovastatin by Modified Locust Bean Gum Using Solid Dispersion Techniques. AAPS PharmSciTech 2008;9(4):1262- 1269.

  • Srichmroen A. Influence of temperature and salt on viscosity roperty of guar gum. Naresuan University Journal 2007;15(2):55- 62.

  • Shin SC, Oh IJ, Lee YB. Enhanced dissolution of furosemideby coprecipitating or cogrinding with crospovidone. Int J Phar 1998:175(1):17-24.

  • Xu F, Sun L, Tan Z, Liang J, Thermodynamic study of ibuprofen by adiabatic calorimetry and thermal analysis. Thermichimica Acta 2004;412(1-2):33-57.

  • Maheshwari M, Ketkar A, Chauhan B, Patil V. Preparation and characterization of ibuprofen- cetyl alcohol beads by melt solidification technique: effect of variables. Int J Pharm 2003;261(1-2):57-67.

  • Garzon LC, Martinez S, Temperature dependence of solubility for ibuprofen in some organic and aqueous solvents. J Sol Chem 2004;13(11):1379-1385.

  • Modi A, Tayade P. Enhancement of dissolution profile by solid dispersion technique. Aaps Pharma Sci Tech 2006;7(3):E1-6.


Abstract Views: 536

PDF Views: 82




  • Enhancement of Solubility and Dissolution Rate of Poorly Water Soluble Drug by Using Modified Guar Gum

Abstract Views: 536  |  PDF Views: 82

Authors

Vipul V. Jambukiya
Dept. of Pharmaceutics, Saurashtra University, Rajkot -360005, India
Ramesh B. Parmar
Dept. of Pharmaceutics, Saurashtra University, Rajkot -360005, India
Ashvin V. Dudhrejiya
Dept. of Pharmaceutics, Saurashtra University, Rajkot -360005, India
H. M. Tank
Dept. of Pharmaceutics, Saurashtra University, Rajkot -360005, India
Vipul D. Limbachiya
Dept. of Pharmaceutics, Saurashtra University, Rajkot -360005, India

Abstract


Introduction: The increasing interest of the technology of dosage form with natural biopolymers has become the reason for undertaking present investigation on the possibility of guar gum application in the preparation of an oral solid dosage form of a poorly water soluble drug.

Method: Present study examines the effect of Guar gum (GG) and Modified guar gum (MGG) on the oral bioavailability of a poorly water-soluble drug, Ibuprofen (IBU). Modified guar gum (MGG) was prepared using heat treatment (125-130oC for 2 to 3 hours) method. It was characterized for viscosity, swelling index and water retention capacity. The physical and co-grinding mixtures of IBU with GG and MGG were prepared in 1:9 drug to gum ratio. The physical and co-grinding mixtures were characterized by DSC and FT-IR study.

Results: The studies confirmed that there was no interaction between drug and carrier. Prepared mixtures were evaluated for solubility study and in vitro dissolution studies using USP XXIII Dissolution apparatus. The rank order of solubility and dissolution study was IBU < grounded IBU < Physical mixture of IBU and GG < Physical mixture of IBU and MGG < Co-grinding mixture of IBU and GG < Co-grinding mixture of IBU and MGG.

Conclusion: The results of present investigation indicated that co-grinding mixture of ibuprofen with modified guar gum could be useful in developing an oral dosage form with improved dissolution and oral bioavailability of poorly water soluble drug.


Keywords


Guar Gum, Modified Guar Gum, Dissolution Rate Enhancement, Poorly Soluble Drug.

References