Asian Journal of Research in Pharmaceutical Sciences

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Hepatoprotective Activity of Ardisia solanacea in CCL4 Induced Hepatoxic Albino Rats


Affiliations
1 SLT Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh, India
     

   Subscribe/Renew Journal


The objective of this study was to investigate the hepatoprotective activity of alcoholic extract of Ardisia solanacea leaves against carbon tetrachloride (CCL4) induced hepatotoxicity. The plant material were dried in shade then powdered and extracted with alcohol. Preliminary phytochemical tests were done. Alcoholic extract showed presence of phenolic compound and flavanoids. The hepatoprotective activity of the alcoholic extract was assessed in CCL4 induced hepatotoxic rats. Alteration in the levels of biochemical markers of hepatic damage like SGOT, SGPT, ALP, Billirubin and Protein were tested in both CCL4 treated and untreated groups. CCL4 (1ml) has enhanced the SGOT, SGPT, ALP and Total Billirubin where decrease in total protein level in liver. Treatment of alcoholic extract of Ardisia Solanacea (200mg/kg) has brought back the altered levels of biochemical markers to the near normal levels in the dose dependent manner. Our findings suggested that Ardisia Solanacea alcoholic leaf extract possessed hepatoprotective activity. Moreover, it prevented CCL4induced prolongation in pentobarbital sleeping time confirming hepatoprotectivity and validates the traditional use of this plant against liver damage.

Keywords

Ardisia solanacea, Hepatoprotective, Silymarin, CCL4, Alcohol.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Handa, S.S., Sharma, A., Chakraborthi, K.K., 1986. Natural products and plants as liver protecting agents. Fitoterapia LVII (5), 307-351.

  • Treadway, S., 1998. An ayurvedic approach to a healthy liver. Clinical Nutrition Insights 16, 1-4.

  • De S, Ravishankar B, Bhavsar GC. Plants with hepatoprotective activity-A review. Indian Drugs. 1993;30(8):355-63.

  • Kokate CK, Purohit AP, Gokhale SB. Text book of pharmacognosy, Nirali Prakashan, Pune. 1996; 4: 510-11.

  • Shenoy KA, Somayaji SN, Bairy KL. Hepatoprotective effects of Ginkgo biloba against carbon tetrachloride induced hepatic injury in rats. Indian J Pharmacolgy. 2001; 45(4): 435-441.

  • Trease GE., Evans MC. Text book of Pharmacognosy London, BailliareTindall; 1983; 12:193,336.

  • Kokate CK, Purohit AP, Gokhale SB. Text book of pharmacognosy, Nirali Prakashan, Pune. 1996; 4: 510-11.

  • Khandelwal KR. Practical Pharmacognosy.Techniques and Experiments Pune, Nirali Prakashan, 2000; 2:149-155.

  • Oloyede OL. Chemical profile of Pulp of Carica papaya. Pakikistan J Nutrition. 2005; 4 (6) :379-381.

  • Liu, G.T., 1989. Pharmacological actions and clinical use of Fructus shizandrae. Journal of Chinese Medicine 102, 740-749.

  • Clauson, G.A., 1989. Mechanism of carbon tetrachloride hepatotoxicity. Pathology and Immunopathology Research 8, 104-112.

  • Rubinstein, D., 1962. Epinephrine release and liver glycogen levels after carbon tetrachloride administration. American Journal of Physiology 203, 1033-1037.

  • Recknagel, R.O., Glende, E.A., Dolak, J.A., Waller, R.L., 1989. Mechanism of carbon tetrachloride toxicity. Pharmacological Therapy 43, 139-154.

  • Halliwell, B., Gutteridge, J.M., 1984. Lipid peroxidation, oxygen radicals, cell damage, and antioxidant therapy. Lancet 1, 1396-1397.

  • Liu, G.T., 1989. Pharmacological actions and clinical use of Fructus shizandrae. Journal of Chinese Medicine 102, 740-749.

  • Rees, K.R., Spector, W.G., 1961. Reversible nature of liver cell damage due to carbon tetrachloride as demonstrated by the use of Phenergan. Nature (London) 189, 821-829.

  • Morazzoni, P., Bombardelli, E., 1995. Silybium marianum (Carduus marianus). Fitoterapia 66, 3-42.

  • Ramellini, G., Meldolesi, J., 1976. Liver protection by silymarin. In vitro effects on dissociated rat hepatocytes. Arzneimittel Forschung (Drug Research) 26, 69-73.


Abstract Views: 268

PDF Views: 3




  • Hepatoprotective Activity of Ardisia solanacea in CCL4 Induced Hepatoxic Albino Rats

Abstract Views: 268  |  PDF Views: 3

Authors

Pradeep Kumar Samal
SLT Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh, India

Abstract


The objective of this study was to investigate the hepatoprotective activity of alcoholic extract of Ardisia solanacea leaves against carbon tetrachloride (CCL4) induced hepatotoxicity. The plant material were dried in shade then powdered and extracted with alcohol. Preliminary phytochemical tests were done. Alcoholic extract showed presence of phenolic compound and flavanoids. The hepatoprotective activity of the alcoholic extract was assessed in CCL4 induced hepatotoxic rats. Alteration in the levels of biochemical markers of hepatic damage like SGOT, SGPT, ALP, Billirubin and Protein were tested in both CCL4 treated and untreated groups. CCL4 (1ml) has enhanced the SGOT, SGPT, ALP and Total Billirubin where decrease in total protein level in liver. Treatment of alcoholic extract of Ardisia Solanacea (200mg/kg) has brought back the altered levels of biochemical markers to the near normal levels in the dose dependent manner. Our findings suggested that Ardisia Solanacea alcoholic leaf extract possessed hepatoprotective activity. Moreover, it prevented CCL4induced prolongation in pentobarbital sleeping time confirming hepatoprotectivity and validates the traditional use of this plant against liver damage.

Keywords


Ardisia solanacea, Hepatoprotective, Silymarin, CCL4, Alcohol.

References