Asian Journal of Research in Pharmaceutical Sciences

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Mechanistic Approach to Determination of Anti-diabetic Activity of Calystegia Sepium R.Br. Flowering Plants in Normal and Streptozotocin Induced Rats


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1 Institute of Pharmaceutical Science and Research centre, Bhagwant University, Ajmer, India
     

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The Hypoglycemic effect of water and ethanol extracts of Calystegia sepium flowering plants has been evaluated and compared its Hypoglycemic effect of flowering plants with Glibenclamide in Euglycemic and Hyperglycemic Wistar rats. Male Wistar rats were orally administered Alcoholic and Water extracts of Calystegia sepium flowering plant and investigated for Hypoglycemic activity in Normal and Streptozotocin (STZ)-induced diabetic rats and compared their effect with Glibenclamide [Single dose one day study and multiple dose15 day study] Blood glucose levels were estimated at 0th, 5th, 10th and 15th day by Kit method and on 15th day lipid profiles were also estimated and other parameters like insulin estimation, insulin tolerance test, and glucose uptake by isolated hemi-diaphragm was estimated. The alcoholic and water extract of Calystegia sepium flower in plant exhibited significant Hypoglycemic and Hypolipidemic effect in Euglycemic and Hyperglycemic rats. The study reveals the hypoglycemic and hypolipidemic activity of alcoholic and water extract of Calystegia sepium flowering plants in euglycemic and Streptozotocin induced diabetic rats. The extract seems promising for the development of a phyto-medicine for a Diabetes mellitus.

Keywords

Diabetes Mellitus, Antihyperglycemic, Hypolipidemic, Euglycemic Calystegia Sepium.
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  • Mechanistic Approach to Determination of Anti-diabetic Activity of Calystegia Sepium R.Br. Flowering Plants in Normal and Streptozotocin Induced Rats

Abstract Views: 352  |  PDF Views: 4

Authors

Kumari Anjali Jain
Institute of Pharmaceutical Science and Research centre, Bhagwant University, Ajmer, India

Abstract


The Hypoglycemic effect of water and ethanol extracts of Calystegia sepium flowering plants has been evaluated and compared its Hypoglycemic effect of flowering plants with Glibenclamide in Euglycemic and Hyperglycemic Wistar rats. Male Wistar rats were orally administered Alcoholic and Water extracts of Calystegia sepium flowering plant and investigated for Hypoglycemic activity in Normal and Streptozotocin (STZ)-induced diabetic rats and compared their effect with Glibenclamide [Single dose one day study and multiple dose15 day study] Blood glucose levels were estimated at 0th, 5th, 10th and 15th day by Kit method and on 15th day lipid profiles were also estimated and other parameters like insulin estimation, insulin tolerance test, and glucose uptake by isolated hemi-diaphragm was estimated. The alcoholic and water extract of Calystegia sepium flower in plant exhibited significant Hypoglycemic and Hypolipidemic effect in Euglycemic and Hyperglycemic rats. The study reveals the hypoglycemic and hypolipidemic activity of alcoholic and water extract of Calystegia sepium flowering plants in euglycemic and Streptozotocin induced diabetic rats. The extract seems promising for the development of a phyto-medicine for a Diabetes mellitus.

Keywords


Diabetes Mellitus, Antihyperglycemic, Hypolipidemic, Euglycemic Calystegia Sepium.

References