Asian Journal of Research in Pharmaceutical Sciences

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Antistress Activity of Aqueous Extract of Leaves of Centella asiatica. Linn by In Vivo Methods


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1 Department of Pharmacology, Annai Veilankanni's Pharmacy College, Chennai-15, India
     

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The antistress activity of aqueous extract of Centella asiatica. Linn leaves (Umbelliferae) were studied at doses of 100mg and 200mg/kg against tail suspension test. A dose dependent reduction in immobility time was observed in TST. Imipramine (30mg/kg, i.p) was selected as reference standard. The extract also significantly potentiate the Phenobarbitone induced sleeping time in mice. The findings from the present investigation indicates the extract has significant antistress as shown by its effects on different experimentally induced animal models.

Keywords

Centella asiatica, Antistress, Tail Suspension Test, Phenobarbitone Induced Sleeping Time.
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  • Antistress Activity of Aqueous Extract of Leaves of Centella asiatica. Linn by In Vivo Methods

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Authors

P. Thamarai Selvi
Department of Pharmacology, Annai Veilankanni's Pharmacy College, Chennai-15, India
M. Senthil Kumar
Department of Pharmacology, Annai Veilankanni's Pharmacy College, Chennai-15, India
T. Kathiravan
Department of Pharmacology, Annai Veilankanni's Pharmacy College, Chennai-15, India
R. Rajesh
Department of Pharmacology, Annai Veilankanni's Pharmacy College, Chennai-15, India
J. Megala
Department of Pharmacology, Annai Veilankanni's Pharmacy College, Chennai-15, India
S. Sravani
Department of Pharmacology, Annai Veilankanni's Pharmacy College, Chennai-15, India

Abstract


The antistress activity of aqueous extract of Centella asiatica. Linn leaves (Umbelliferae) were studied at doses of 100mg and 200mg/kg against tail suspension test. A dose dependent reduction in immobility time was observed in TST. Imipramine (30mg/kg, i.p) was selected as reference standard. The extract also significantly potentiate the Phenobarbitone induced sleeping time in mice. The findings from the present investigation indicates the extract has significant antistress as shown by its effects on different experimentally induced animal models.

Keywords


Centella asiatica, Antistress, Tail Suspension Test, Phenobarbitone Induced Sleeping Time.

References