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Homologous DNA Repair:Safeguarding Genome Territories from Knives


Affiliations
1 Department of Microbiology and Molecular Genetics, University of the Punjab, Quaid-e-Azam Campus, Lahore 54590, Pakistan
2 Department of Allied Health Sciences, University of Health Sciences, Lahore 54000, Pakistan
 

DNA damage agents constantly target the genome integrity causing lethal damages. Homologous DNA repair as universal error-free repair pathway constitutively acts to remove double strand breaks. Tumour suppressor genes are the major candidates and mediators of this pathway. In this context, we review the emerging role of BRCA1/PALB2/BRCA2/RAD51 complex and show how BRCA1 interact with different protein partners to be the first-line mediator of homologous DNA repair pathway at the site of DNA damage. A defect anywhere in this BRCA1/PALB2/BRCA2/RAD51 assembly halts formation and stabilization of nuclear foci of BRCA2 at DNA damage sites compromising HDR repair progression.

Keywords

Breast Cancer Susceptibity Gene 1, Hereditary Breast Cancer, Phosphorylation, Replication Protein A, Strand Invasion.
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  • Homologous DNA Repair:Safeguarding Genome Territories from Knives

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Authors

Saba Abass
Department of Microbiology and Molecular Genetics, University of the Punjab, Quaid-e-Azam Campus, Lahore 54590, Pakistan
Warda Fatima
Department of Microbiology and Molecular Genetics, University of the Punjab, Quaid-e-Azam Campus, Lahore 54590, Pakistan
Saqib Mahmood
Department of Allied Health Sciences, University of Health Sciences, Lahore 54000, Pakistan

Abstract


DNA damage agents constantly target the genome integrity causing lethal damages. Homologous DNA repair as universal error-free repair pathway constitutively acts to remove double strand breaks. Tumour suppressor genes are the major candidates and mediators of this pathway. In this context, we review the emerging role of BRCA1/PALB2/BRCA2/RAD51 complex and show how BRCA1 interact with different protein partners to be the first-line mediator of homologous DNA repair pathway at the site of DNA damage. A defect anywhere in this BRCA1/PALB2/BRCA2/RAD51 assembly halts formation and stabilization of nuclear foci of BRCA2 at DNA damage sites compromising HDR repair progression.

Keywords


Breast Cancer Susceptibity Gene 1, Hereditary Breast Cancer, Phosphorylation, Replication Protein A, Strand Invasion.

References





DOI: https://doi.org/10.18520/cs%2Fv111%2Fi8%2F1335-1339