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Antibacterial Metabolites from the Sri Lankan Demosponge-Derived Fungus, Aspergillus flavipes


Affiliations
1 Department of Chemistry, University of Colombo, Colombo 03, Sri Lanka
2 Departments of Chemistry and Earth, Ocean and Atmospheric Sciences, University of British Columbia (UBC), Vancouver, Canada
 

Sri Lankan sponge-derived fungi are an unexploited resource awaiting exploration for drug leads. Three fungi from the internal tissues of a demosponge collected on the west coast of Sri Lanka were isolated and antimicrobial activities of their crude extracts were evaluated. Aspochalasin B, D, M, asperphenamate and 4-OMe asperphenamate were isolated from the crude ethyl acetate extract of the fungus Aspergillus flavipes. Aspochalasin B and D showed antibacterial activities against Bacillus subtilis (MIC, 16 and 32 μg ml-1 respectively), Staphylococcus aureus and MRSA (MIC, 32 μg ml-1). The results highlight the potential of isolating bioactive secondary metabolites from Sri Lankan sponge-derived fungi.

Keywords

Aspergillus flavipes, Aspochalasin, Asperphenamate, Demosponge, Marine.
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  • Antibacterial Metabolites from the Sri Lankan Demosponge-Derived Fungus, Aspergillus flavipes

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Authors

Pamoda B. Ratnaweera
Department of Chemistry, University of Colombo, Colombo 03, Sri Lanka
David E. Williams
Departments of Chemistry and Earth, Ocean and Atmospheric Sciences, University of British Columbia (UBC), Vancouver, Canada
E. Dilip de Silva
Department of Chemistry, University of Colombo, Colombo 03, Sri Lanka
Raymond J. Andersen
Departments of Chemistry and Earth, Ocean and Atmospheric Sciences, University of British Columbia (UBC), Vancouver, Canada

Abstract


Sri Lankan sponge-derived fungi are an unexploited resource awaiting exploration for drug leads. Three fungi from the internal tissues of a demosponge collected on the west coast of Sri Lanka were isolated and antimicrobial activities of their crude extracts were evaluated. Aspochalasin B, D, M, asperphenamate and 4-OMe asperphenamate were isolated from the crude ethyl acetate extract of the fungus Aspergillus flavipes. Aspochalasin B and D showed antibacterial activities against Bacillus subtilis (MIC, 16 and 32 μg ml-1 respectively), Staphylococcus aureus and MRSA (MIC, 32 μg ml-1). The results highlight the potential of isolating bioactive secondary metabolites from Sri Lankan sponge-derived fungi.

Keywords


Aspergillus flavipes, Aspochalasin, Asperphenamate, Demosponge, Marine.

References





DOI: https://doi.org/10.18520/cs%2Fv111%2Fi9%2F1473-1479