Biocompatibility of Synthetic and Bio-Material Fusion

This communication proposes methods to improve the biocompatibility performance of synthetic materials for biological and biological material for synthetic applications. π-cloud extension by suitable ligand- ligand/metal-ligand interactions can make the synthetic-biological fusion suitable for such applications. The judicious use of ligands for π-cloud extension can be applied to carbon transformations and target-oriented drug delivery systems. Embedded metal-centre catalysts for synthetic-biological fusion include: (i) axial coordination via bridging ligands; (ii) ligands with weak to intermediate field strength and multidenticities; (iii) design of inert complexes, and (iv) development of multi-nuclear complexes.