Current Science

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The objective of the present study was to explore the alleviatory effects of hydroalcoholic extract of Brassica oleracea var. botrytis (BOB) leaves against sodium fluoride (NaF)-induced cardiotoxicity. Animals served as group I (normal control), group II (toxic control) and groups III-V (treatment groups) received extract at doses of 100, 200 and 400 mg/kg body wt respectively. Group VI served as plant control and received extract at a dose of 400 mg/kg body wt. All groups, except groups I and VI, received NaF (100 ppm) through drinking water for 30 days. Results showed that administration of extract significantly minimized elevated serum levels of CK-MB and LDH, decreased cardiac lipid peroxidation, increased levels of reduced glutathione content and catalase enzyme in a dosedependent manner. The study revealed that BOB leaves show moderate antioxidant and alleviated sodium fluoride induced cardiotoxicity.

Keywords

Antioxidant Activity, Cardiac Markers, Cauliflower Leaves, Hydroalcoholic Extract, Sodium Fluoride.
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