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Cell Culture Processes for Biopharmaceutical Manufacturing


Affiliations
1 Chemical Engineering and Process Development Division, CSIR-National Chemical Laboratory, Pune 411 008, India
 

Recombinant proteins manufactured using animal cell culture processes comprise a significant fraction of biopharmaceuticals. With the expiry of patents on this class of therapeutics, there is also a significant interest in manufacture of biosimilar versions of such therapeutics. This article provides a birds-eye view of upstream process development for animal cell culture processes, with a focus on advances pertinent to the development of processes for biosimilars.

Keywords

Biopharmaceutical, CHO, Cell Line Development, Glycosylation, Monoclonal Antibody.
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  • Cell Culture Processes for Biopharmaceutical Manufacturing

Abstract Views: 455  |  PDF Views: 124

Authors

Mugdha Gadgil
Chemical Engineering and Process Development Division, CSIR-National Chemical Laboratory, Pune 411 008, India

Abstract


Recombinant proteins manufactured using animal cell culture processes comprise a significant fraction of biopharmaceuticals. With the expiry of patents on this class of therapeutics, there is also a significant interest in manufacture of biosimilar versions of such therapeutics. This article provides a birds-eye view of upstream process development for animal cell culture processes, with a focus on advances pertinent to the development of processes for biosimilars.

Keywords


Biopharmaceutical, CHO, Cell Line Development, Glycosylation, Monoclonal Antibody.

References





DOI: https://doi.org/10.18520/cs%2Fv112%2Fi07%2F1478-1488