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An Insight into the Putative Role of Victuals Like Honey and its Polyphenols in Breast Cancer


Affiliations
1 Universiti Teknologi Malaysia, Johor Bahru 81310, Malaysia
2 Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City, Viet Nam
3 Department of Chemistry, Bharath University, Chennai 600 073, India
4 IJNU-TM Cardiovascular Engineering Center, Universiti Teknologi Malaysia, Skudai 81300, Johor, Malaysia
 

Diet plays a crucial role in cancer advancement as well as prevention. Breast cancer is the second leading cause of cancer death among women. Recent research links breast cancer with diet and some evidence for the preventive effect of diet against breast cancer was also documented. The growth of cancer cells is influenced by natural sweetener honey and its multitude of phenolic phytochemical components. Honey has been used medicinally by ancient Greeks and Egyptians and also traditionally exploited in Ayurveda and Chinese medicine. In this paper, the anti-cancer properties of honey and its phytochemical's action against breast cancer have been summarized. They result in apoptosis by enhancing reactive oxygen species level, activating mitochondrial pathway, initiation of pro-apoptotic and anti-apoptotic proteins, induction of p53 pathway that finally cause DNA fragmentation. However, there is a necessity for more proteomic and genetic-based experiments to understand its molecular mechanism to promote honey and its phenolic markers as plausible candidates for breast cancer treatment. Further, there is a need for quality check of honey available in the market, which warrants significant investigation by researchers in the food industry to ensure their attributes.

Keywords

Anti-Cancer, Apoptosis, Breast Cancer, Honey, Phenolic.
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  • An Insight into the Putative Role of Victuals Like Honey and its Polyphenols in Breast Cancer

Abstract Views: 491  |  PDF Views: 139

Authors

Aruna Priyadharshni Subramanian
Universiti Teknologi Malaysia, Johor Bahru 81310, Malaysia
Agnes Aruna John
Universiti Teknologi Malaysia, Johor Bahru 81310, Malaysia
Muthu Vignesh Vellayappan
Universiti Teknologi Malaysia, Johor Bahru 81310, Malaysia
Arunpandian Balaji
Universiti Teknologi Malaysia, Johor Bahru 81310, Malaysia
Saravana Kumar Jaganathan
Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City, Viet Nam
A. Manikandan
Department of Chemistry, Bharath University, Chennai 600 073, India
Eko Supriyanto
IJNU-TM Cardiovascular Engineering Center, Universiti Teknologi Malaysia, Skudai 81300, Johor, Malaysia

Abstract


Diet plays a crucial role in cancer advancement as well as prevention. Breast cancer is the second leading cause of cancer death among women. Recent research links breast cancer with diet and some evidence for the preventive effect of diet against breast cancer was also documented. The growth of cancer cells is influenced by natural sweetener honey and its multitude of phenolic phytochemical components. Honey has been used medicinally by ancient Greeks and Egyptians and also traditionally exploited in Ayurveda and Chinese medicine. In this paper, the anti-cancer properties of honey and its phytochemical's action against breast cancer have been summarized. They result in apoptosis by enhancing reactive oxygen species level, activating mitochondrial pathway, initiation of pro-apoptotic and anti-apoptotic proteins, induction of p53 pathway that finally cause DNA fragmentation. However, there is a necessity for more proteomic and genetic-based experiments to understand its molecular mechanism to promote honey and its phenolic markers as plausible candidates for breast cancer treatment. Further, there is a need for quality check of honey available in the market, which warrants significant investigation by researchers in the food industry to ensure their attributes.

Keywords


Anti-Cancer, Apoptosis, Breast Cancer, Honey, Phenolic.

References





DOI: https://doi.org/10.18520/cs%2Fv112%2Fi09%2F1839-1854