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Wound Healing Materials - A Perspective for Skin Tissue Engineering


Affiliations
1 School of Bio Sciences and Technology, VIT University, Vellore 632 014, India
2 Department of Manufacturing, School of Mechanical Engineering, VIT University, Vellore 632 014, India
 

Skin injury and wound healing are complex biological and intricate processes that involve activation of intercellular pathways, co-ordination of tissue integrity and homeostasis. The wound can be acute and chronic depending upon the nature and depth of the injury. A wide variety of dressing materials is available to enhance the wound healing process. An ideal dressing should act as a three-dimensional template which can mimic extracellular matrix, be biologically stable, flexible and can remove wound exudate by providing a moist environment to the wound site. It should form a protective bed to cover the wound from external hazards. This article presents a review of wound dressings made of natural and synthetic polymers or a combination of both. A variety of commercial wound healing materials is discussed briefly.

Keywords

Extra Cellular Matrix, Polymer Dressings, Skin Injury, Wound Healing.
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  • Zhong, S. P., Zhang, Y. Z. and Lim, C. T., Tissue scaffolds for skin wound healing and dermal reconstruction. Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol., 2010, 2, 510–525.

  • Gurtner, G. C., Werner, S., Barrandon, Y. and Longaker, M. T., Wound repair and regeneration. Nature, 2008, 453, 314–321.

  • Pastar, I. et al., Epithelialization in wound healing: a comprehensive review. Adv. Wound Care, 2014, 3, 445–464.

  • Hussain, S. H., Limthongkul, B. and Humphreys, T. R., The biomechanical properties of the skin. Dermatologic Surg., 2013, 39, 193–203.

  • Shakespeare, P., Burn wound healing and skin substitutes. Burns, 2001, 27, 517–522.

  • Sezer, A. D. and Cevher, E., Biopolymers as wound healing materials: challenges and new strategies, Chapter 19, In Biomaterials Applications for Nanomedicine (ed. Pignatello, R.), 2011, In Tech Publisher.

  • Langer, R. and Vacanti, J. P., Tissue engineering. Science, 1993, 260, 920–926.

  • Suganya, S., Venugopal, J., Ramakrishna, S., Lakshmi, B. S. and Dev, V. R. G., Naturally derived biofunctional nanofibrous scaffold for skin tissue regeneration. Int. J. Biol. Macromol., 2014, 68, 135–143.

  • Aarabi, S., Longaker, M. T. and Gurtner, G. C., Hypertrophic scar formation following burns and trauma: New approaches to treatment. PLOS Med., 2007, 4, 1464–1470.

  • Powers, J. G., Morton, L. M. and Phillips, T. J., Dressings for chronic wounds. Dermatol. Ther., 2013, 26, 197–206.

  • Clark, R. F., Ghosh, K. and Tonnesen, M. G., Tissue engineering for cutaneous wounds. J. Invest. Dermatol., 2007, 127, 1018–1029.

  • Park, M. et al., Effect of discarded keratin-based biocomposite hydrogels on the wound healing process in vivo. Mater. Sci. Eng. C, 2015, 55, 88–94.

  • Albanna, M. Z., Holmes IV, J. H., Sanon, S., Hart, D. A. and Tredget, E. E., Molecular and cellular biology of wound healing and skin regeneration. Skin Tissue Eng. Regenerative Med., 2016, 19–47, chapter 2.

  • Susie, S., Dressing selection in chronic wound management. J. Am. Podiatr. Med. Assoc., 2002, 1, 24–33.

  • Friedstat, J. S. and Klein, M. B., Acute management of facial burns. Clin. Plast. Surg., 2009, 36, 653–660.

  • Dai, T., Tanaka, M., Huang, Y. Y. and Hamblin, M. R., Chitosan preparations for wounds and burns: antimicrobial and woundhealing effects. Exp. Rev. Anti. Infect. Ther., 2011, 9, 857–879.

  • Sun, G. et al., Dextran hydrogel scaffolds enhance angiogenic responses and promote complete skin regeneration during burn wound healing. Proc. Natl. Acad. Sci. USA, 2011, 108, 20976–20981.

  • Ma, B., Xie, J., Jiang, J. and Wu, J., Sandwich-type fiber scaffolds with square arrayed microwells and nanostructured cues as microskin grafts for skin regeneration. Biomaterials, 2014, 35, 630–641.

  • Harding, K. G., Morris, H. L. and Patel, G. K., Healing chronic wounds the clinical burden of wounds. BMJ, 2002, 324, 160–163.

  • Colwell, A. S., Longaker, M. T. and Lorenz, H. P., Fetal wound healing. Front. Biosci., 2003, 8, 1240–1248.

  • Metcalfe, A. D. and Ferguson, M. W. J., Skin stem and progenitor cells: using regeneration as a tissue-engineering strategy. Cell Mol. Life Sci., 2008, 65, 24–32.

  • Trent, J. T. and Kirsner, R. S., Wounds and malignancy. Adv. Skin Wound Care, 2003, 16, 31–34.

  • Troxler, M., Vowden, K. and Vowden, P., Integrating adjunctive therapy into practice: the importance of recognising ‘hard-to-heal’ wounds. World Wide Wounds, 2006.

  • Sood, A., Granick, M. S. and Tomaselli, N. L., Wound dressings and comparative effectiveness data. Adv. Wound Care, 2014, 3, 511–529.

  • Pham, C., Greenwood, J., Cleland, H., Woodruff, P. and Maddern, G., Bioengineered skin substitutes for the management of burns: a systematic review. Burns, 2007, 33, 946–957.

  • Mogossanu, G. D. and Grumezescu, A. M., Natural and synthetic polymers for wounds and burns dressing. Int. J. Pharm., 2014, 463, 127–136.

  • Kamolz, L. P. and Wild, T., Wound bed preparation: the impact of debridement and wound cleansing. Wound Med., 2013, 1, 44–50.

  • Lee, C. H., Singla, A. and Lee, Y., Biomedical applications of collagen. Int. J. Pharm., 2001, 221, 1–22.

  • Moura, L. I. F., Dias, A. M. A., Carvalho, E. and De Sousa, H. C., Recent advances on the development of wound dressings for diabetic foot ulcer treatment: A review. Acta Biomater., 2013, 9, 7093–7114.

  • Gopinath, D. et al., Dermal wound healing processes with curcumin incorporated collagen films. Biomaterials, 2004, 25, 1911–1917.

  • Arul, V. et al., Glucose oxidase incorporated collagen matrices for dermal wound repair in diabetic rat models: a biochemical study. J. Biomater. Appl., 2012, 26, 917–938.

  • Moura, L. I. F. et al., Neurotensin-loaded collagen dressings reduce inflammation and improve wound healing in diabetic mice. Biochim. Biophys. Acta, 2014, 1842, 32–43.

  • Wang, T. W. et al., The effect of gelatin-chondroitin sulfatehyaluronic acid skin substitute on wound healing in SCID mice. Biomaterials, 2006, 27, 5689–5697.

  • Liu, H. et al., A study on a chitosan-gelatin-hyaluronic acid scaffold as artificial skin in vitro and its tissue engineering applications. J. Biomater. Sci. Polym. Ed., 2004, 15, 25–40.

  • Li, D., Ye, Y., Li, D., Li, X. and Mu, C., Biological properties of dialdehyde carboxymethyl cellulose crosslinked gelatin–PEG composite hydrogel fibers for wound dressings. Carbohydr. Polym., 2016, 137, 508–514.

  • Sweeney, I. R., Miraftab, M. and Collyer, G., Absorbent alginate fibres modified with hydrolysed chitosan for wound care dressings – II. Pilot scale development. Carbohydr. Polym., 2014, 102, 920–927.

  • Wang, L. et al., Evaluation of sodium alginate for bone marrow cell tissue engineering. Biomaterials, 2003, 24, 3475–3481.

  • Sannino, A., Demitri, C. and Madaghiele, M., Biodegradable cellulose-based hydrogels: design and applications. Materials (Basel), 2009, 2, 353–373.

  • Rezvanian, M., Amin, M. C. I. M. and Ng, S. F., Development and physicochemical characterization of alginate composite film loaded with simvastatin as a potential wound dressing. Carbohydr. Polym., 2016, 137, 295–304.

  • Manjubala, I., Scheler, S., Bössert, J. and Jandt, K. D., Mineralisation of chitosan scaffolds with nano-apatite formation by double diffusion technique. Acta Biomater., 2006, 2, 75–84.

  • Huang, R. et al., Biomimetic LBL structured nanofibrous matrices assembled by chitosan/collagen for promoting wound healing. Biomaterials, 2015, 324, 160–163.

  • Ma, L. et al., Collagen/chitosan porous scaffolds with improved biostability for skin tissue engineering. Biomaterials, 2003, 24, 4833–4841.

  • Fan, L., Yang, H., Yang, J., Peng, M. and Hu, J., Preparation and characterization of chitosan/gelatin/PVA hydrogel for wound dressings. Carbohydr. Polym., 2016, 146, 427–434.

  • Chen, S. H. et al., Assessment of reinforced poly(ethylene glycol) chitosan hydrogels as dressings in a mouse skin wound defect model. Mater. Sci. Eng. C, 2013, 33, 2584–2594.

  • Anjum, S., Arora, A., Alam, M. S. and Gupta, B., Development of antimicrobial and scar preventive chitosan hydrogel wound dressings. Int. J. Pharm., 2016, 508, 92–101.

  • Kondo, S. and Kuroyanagi, Y., Development of a wound dressing composed of hyaluronic acid and collagen sponge with epidermal growth factor. J. Biomater. Sci. Polym. Ed., 2012, 23, 629–643.

  • Uppal, R., Ramaswamy, G. N., Arnold, C., Goodband, R. and Wang, Y., Hyaluronic acid nanofiber wound dressing-production, characterization, and in vivo behavior. J. Biomed. Mater. Res. – Part B Appl. Biomater., 2011, 97B, 20–29.

  • Kakkar, P., Verma, S., Manjubala, I. and Madhan, B., Development of keratin chitosan-gelatin composite scaffold for soft tissue engineering. Mater. Sci. Eng. C. Mater. Biol. Appl., 2014, 45, 343–347.

  • Vacík, J. et al., Cultivation of human keratinocytes without feeder cells on polymer carriers containing ethoxyethyl methacrylate: In vitro study. J. Mater. Sci. Mater. Med., 2008, 19, 883–888.

  • Singaravelu, S., Ramanathan, G., Raja, M. D., Barge, S. and Sivagnanam, U. T., Preparation and characterization of keratinbased biosheet from bovine horn waste as wound dressing material. Mater. Lett., 2015, 152, 90–93.

  • Chang, C., Duan, B., Cai, J. and Zhang, L., Superabsorbent hydrogels based on cellulose for smart swelling and controllable delivery. Eur. Polym. J., 2009, 46, 92–100.

  • Wei, B., Yang, G. and Hong, F., Preparation and evaluation of a kind of bacterial cellulose dry films with antibacterial properties. Carbohydr. Polym., 2011, 84, 533–538.

  • Fu, L., Zhou, P., Zhang, S. and Yang, G., Evaluation of bacterial nanocellulose-based uniform wound dressing for large area skin transplantation. Mater. Sci. Eng. C, 2103, 33, 2995–3000.

  • Hong, L. et al., Hydroxyapatite/bacterial cellulose composites synthesized via a biomimetic route. Mater. Lett., 2006, 60, 1710–1713.

  • Song, A., Rane, A. A. and Christman, K. L., Antibacterial and cell-adhesive polypeptide and poly(ethylene glycol) hydrogel as a potential scaffold for wound healing. Acta Biomater., 2012, 8, 41–50.

  • Siritienthong, T., Ratanavaraporn, J. and Aramwit, P., Development of ethyl alcohol-precipitated silk sericin/polyvinyl alcohol scaffolds for accelerated healing of full-thickness wounds. Int. J. Pharm., 2012, 439, 175–186.

  • Shi, L. et al., A novel poly( -glutamic acid)/silk-sericin hydrogel for wound dressing: synthesis, characterization and biological evaluation. Mater. Sci. Eng. C, 2015, 48, 533–540.

  • Akturk, O. et al., Evaluation of sericin/collagen membranes as prospective wound dressing biomaterial. J. Biosci. Bioeng., 2011, 112, 279–288.

  • Baoyong, L., Jian, Z., Denglong, C. and Min, L., Evaluation of a new type of wound dressing made from recombinant spider silk protein using rat models. Burn, 2010, 36, 891–896.

  • Chen, G. et al., Culturing of skin fibroblasts in a thin PLGA-collagen hybrid mesh. Biomaterials, 2005, 26, 2559–2566.

  • Shahverdi, S. et al., Fabrication and structure analysis of poly(lactide-co-glycolic acid)/silk fibroin hybrid scaffold for wound dressing applications. Int. J. Pharm., 2014, 473, 345–355.

  • Torchilin, V. P., PEG-based micelles as carriers of contrast agents for different imaging modalities. Adv. Drug Deliv. Rev., 2002, 54, 235–252.

  • Jeon, Y. H. et al., Different effects of PLGA and chitosan scaffolds on human cartilage tissue engineering. J. Craniofac. Surg., 2007, 18, 1249–1258.

  • Dong, Y. et al., Performance of an in situ formed bioactive hydrogel dressing from a PEG-based hyperbranched multifunctional copolymer. Acta Biomater., 2014, 10, 2076–2085.

  • Zhu, J., Bioactive modification of poly(ethylene glycol) hydrogels for tissue engineering. Biomaterials, 2010, 31, 4639–4656.

  • Craig, D. Q. M., The mechanisms of drug release from solid dispersions in water soluble polymers. Int. J. Pharm., 2002, 231, 131–144.

  • Kim, J. O. et al., Development of clindamycin-loaded wound dressing with polyvinyl alcohol and sodium alginate. Biol. Pharm. Bull., 2008, 31, 2277–2282.

  • Vashisth, P. et al., A novel gellan–PVA nanofibrous scaffold for skin tissue regeneration: fabrication and characterization. Carbohydr. Polym., 2016, 136, 851–859.

  • El-Sayed, S., Mahmoud, K. H., Fatah, A. A. and Hassen, A., DSC, TGA and dielectric properties of carboxymethyl cellulose/ polyvinyl alcohol blends. Phys. B Condens. Matter, 2011, 406, 4068–4076.

  • Lakshman, L., Shalumon, K. T., Nair, S., Jayakumar, R. and Nair, S. V., Preparation of silver nanoparticles incorporated electrospun polyurethane nanofibrous mat for wound dressing. J. Macromol. Sci. Part A, 2010, 47, 1012–1018.

  • Vermeulen, H., Ubbink, D. T., Gorssend, A., de Vos, R. and Legimate, D. A., Systematic review of dressings and topical agents for surgical wounds healing by secondary intention. Br. J. Surg., 2005, 6, 665–672.

  • Jung, J. A., Yoo, K. H., Dhong, E. S. and Kim, W. K., Evaluation of the efficacy of highly hydrophilic polyurethane foam dressing in treating a diabetic foot ulcer. Ad Skin Wound Care, 2016, 29, 546–555.

  • Figueira, D. R., Miguel, S. P., de Sa, K. D. and Correia, I. J., Production and characterization of polycaprolactone–hyaluronic acid/chitosan-zein electrospun bilayer nanofibrous membrane for tissue regeneration. Int. J. Biol. Macromolec., 2016, 93, 1100–1110.

  • Milovac, D., Gamboa-Martínez, T. C., Ivankovic, M., Ferrer, G. G. and Ivankovic, H., PCL-coated hydroxyapatite scaffold derived from cuttlefish bone: in vitro cell culture studies. Mater. Sci. Eng. C, 2014, 42, 264–272.

  • Augustine, R., Kalarikkal, Nandakumar, K. and Thomas, S., Electrospun PCL membranes incorporated with biosynthesized silver nanoparticles as antibacterial wound dressings. Appl. Nanosci., 2016, 6, 337–344.

  • Koksal, C. and Bozkurt, A. K., Combination of hydrocolloidal dressing and medical compression stocking versus Unn’s boot for the treatment of venous leg ulcers. Swiss Med. Wkly., 2003, 133, 364–368.

  • Korrapati, P. S. et al., Recent advancements in nanotechnological strategies in selection, design and delivery of biomolecules for skin regeneration. Mater. Sci. Eng. C, 2016, 67, 747–765.

  • Dumville Jo, C., Deshpande, S., O’Meara, S. and Speak, K., Foam dressings for healing diabetic foot ulcers. Cochrane Database of Syst. Rev., 2013.

  • Schiefer, I. et al., A prospective intra-individual evaluation of silk compared to Biobrane for the treatment of superficial burns of the hand and face. Burns, 2017, 43, 539–548.

  • Filton, A., Drew, P. and Dickson W., The use of bilaminate artificial skin substitute (Integra) in acute resurfacing of burns: an early experience. Brit J Plast Surg., 2001, 54, 2018-212.

  • Wood, F. M., Skin regeneration: the complexities of translation into clinical practise. Int. J. Biochem. Cell Biol., 2014, 56, 133–140.

  • Boateng, J. S., Matthews, K. H., Stevens, H. N. E. and Eccleston, G. M., Wound healing dressings and drug delivery systems: a review. J. Pharm. Sci., 2002, 324, 160–163.

  • Gawronska-Kozak, B., Grabowska, A., Kopcewicz, M. and Kur, A., Animal models of skin regeneration. Reprod. Biol., 2014, 14, 61–67.

  • Dhivya, S., Padma, V. and Santhini, E., Wound dressings – a review. Bio. Med., 2015, 5, 24–28.

  • Thomar, S. and MccCubbin, P., A comparison of the antimicrobial effects of four silver-containing dressings on three organisms. J. Wound Care, 2015, 5, 24–28.

  • Dantzer, E. and Braye, F. M., Reconstructive surgery using an artificial dermis (Integra): results with 39 grafts. Br. J. Plast. Surg., 2001, 54, 659–664.

  • Langer, A. and Ragowski, W., Systemic review of economic evaluations of human cell-derived wound care products for the treatment of venous leg and diabetic foot ulcer. BMC Health Service Res., 2009, 9, 115.

  • Webb, A., Li, A. and Kaur, P., Location and phenotype of human adult keratinocyte stem cells of the skin. Differentiation, 2004, 72, 387–395.

  • Scluter, H. and Kaur, P., Bioengineered human skin from embryonic stem cells. Lancet, 2009, 374, 1725–1726.

  • Boateng, J. and Catanzano, C., Advanced therapeutic dressings for effective wound healing – a review. J. Pharm. Sci., 2015, 104, 3653–3680.

  • Liu, J. et al., Hair follicle and sebaceous gland de novo regeneration with cultured epidermal stem cells and skin-derived precursors. Stem Cells Transl Med., 2016, 5, 1695–1706.

  • Tuca, A. C. et al., Comparison of matrigel and matriderm as a carrier for human amnion-derived mesenchymal stem cells in wound healing. Placenta, 2016, 48, 99–103.

  • Chouhan, D., Chakraborty, B., Nandi, S. K. and Mandal, B. B., Role of nonmulberrysilk fibroin in deposition and regulation of extracellular matrix towards accelerated wound healing. Acta Biomater., 2017, 48, 157–174.

  • MacNeil, S., Biomaterials for tissue engineering of skin. Materials Today, 2008, 11, 26–35.


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  • Wound Healing Materials - A Perspective for Skin Tissue Engineering

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Authors

Poulami Basu
School of Bio Sciences and Technology, VIT University, Vellore 632 014, India
U. Narendra Kumar
Department of Manufacturing, School of Mechanical Engineering, VIT University, Vellore 632 014, India
I. Manjubala
School of Bio Sciences and Technology, VIT University, Vellore 632 014, India

Abstract


Skin injury and wound healing are complex biological and intricate processes that involve activation of intercellular pathways, co-ordination of tissue integrity and homeostasis. The wound can be acute and chronic depending upon the nature and depth of the injury. A wide variety of dressing materials is available to enhance the wound healing process. An ideal dressing should act as a three-dimensional template which can mimic extracellular matrix, be biologically stable, flexible and can remove wound exudate by providing a moist environment to the wound site. It should form a protective bed to cover the wound from external hazards. This article presents a review of wound dressings made of natural and synthetic polymers or a combination of both. A variety of commercial wound healing materials is discussed briefly.

Keywords


Extra Cellular Matrix, Polymer Dressings, Skin Injury, Wound Healing.

References





DOI: https://doi.org/10.18520/cs%2Fv112%2Fi12%2F2392-2404