Current Science

Open Access Open Access  Restricted Access Subscription Access

Drug Discovery:Mining Microbes for Bioactive Compounds


Affiliations
1 National Environmental Engineering Research Institute, CSIR, Nehru Marg, Nagpur 440 020, India
2 National Centre for Microbial Resource, Pune 411 021, India
3 Omni Active Health Technologies, Mumbai 400 013, India
 

A collaborative programme involving industry and academia was initiated in September 2007 by the Department of Biotechnology to screen the bacterial diversity from various ecological niches in the country to search for novel bioactive molecules for therapeutic applications. The programme was designed to collect resource samples from the less-explored ecological niches at regular intervals for three years, to ensure a steady supply of microbes for high-throughput screening (HTS). The project had two major components. The first was targeted to generate a repository of 250,000 bacteria in three years by the academic research groups. The other component was preparation of microbial extracts and their screening on HTS platforms in four therapeutic areas followed by chemical profiling of potent extracts. Figure 1 shows the overall project plan.
User
Notifications
Font Size

  • Sharma, A. and Shouche, Y., Indian J. Microbiol., 2014, 54, 129–133.

  • Rossello-Moraa, R. and Amann, R., Syst. Appl. Microbiol., 2015, 38, 209–216.

  • Cuellar, M. C. and van der Wielen, L. A., Curr. Opin. Biotechnol., 2015, 33, 39–45.

  • Harvey, A. L., Edrada-Ebel, R. and Quinn, R. J., Nature Rev. Drug Discovery, 2015, 14, 111–129.

  • Forner, D., Berrue, F., Correa, H., Duncan, K. and Kerr, R. G., Anal. Chim. Acta, 2013, 805, 70–79.

  • Gaudencio, S. P. and Pereira, F., Nat. Prod. Rep., 2015, 32, 779–810.


Abstract Views: 454

PDF Views: 134




  • Drug Discovery:Mining Microbes for Bioactive Compounds

Abstract Views: 454  |  PDF Views: 134

Authors

Hemant J. Purohit
National Environmental Engineering Research Institute, CSIR, Nehru Marg, Nagpur 440 020, India
Yogesh Shouche
National Centre for Microbial Resource, Pune 411 021, India
Arun Balakrishnan
Omni Active Health Technologies, Mumbai 400 013, India

Abstract


A collaborative programme involving industry and academia was initiated in September 2007 by the Department of Biotechnology to screen the bacterial diversity from various ecological niches in the country to search for novel bioactive molecules for therapeutic applications. The programme was designed to collect resource samples from the less-explored ecological niches at regular intervals for three years, to ensure a steady supply of microbes for high-throughput screening (HTS). The project had two major components. The first was targeted to generate a repository of 250,000 bacteria in three years by the academic research groups. The other component was preparation of microbial extracts and their screening on HTS platforms in four therapeutic areas followed by chemical profiling of potent extracts. Figure 1 shows the overall project plan.

References





DOI: https://doi.org/10.18520/cs%2Fv113%2Fi12%2F2234-2236