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5α/5β Stereochemistry of Spirostanol and Furostanol Saponins


Affiliations
1 Natural Products Chemistry and Process Development Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur 176 061, India
2 Near Neugal Chowk, P.O. Bandla, Tea Estate, Palampur - 176 061, India
 

Steroidal saponins constitute an important class of plant secondary metabolites and are mostly found in monocotyledonous angiosperms. These compounds are known to possess a vast array of bioactivities, including anticancer, adjuvant, immunostimulant, anti-inflammatory, antimicrobial, hypocholesterolaemic, antimicrobial and antioxidant1,2. Structurally, steroidal saponins are classified as spirostanol and furostanol glycosides3. A third and relatively less common class of steroidal saponins is furospirostanols. The saponins of this class generally have a polyoxygenated A-ring and/or one or more double bonds present in the rings A and B4.
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  • 5α/5β Stereochemistry of Spirostanol and Furostanol Saponins

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Authors

Jasmeen Sidana
Natural Products Chemistry and Process Development Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur 176 061, India
Bikram Singh
Natural Products Chemistry and Process Development Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur 176 061, India
Om P. Sharma
Near Neugal Chowk, P.O. Bandla, Tea Estate, Palampur - 176 061, India

Abstract


Steroidal saponins constitute an important class of plant secondary metabolites and are mostly found in monocotyledonous angiosperms. These compounds are known to possess a vast array of bioactivities, including anticancer, adjuvant, immunostimulant, anti-inflammatory, antimicrobial, hypocholesterolaemic, antimicrobial and antioxidant1,2. Structurally, steroidal saponins are classified as spirostanol and furostanol glycosides3. A third and relatively less common class of steroidal saponins is furospirostanols. The saponins of this class generally have a polyoxygenated A-ring and/or one or more double bonds present in the rings A and B4.

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DOI: https://doi.org/10.18520/cs%2Fv115%2Fi4%2F618-621