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Oxidized Lipoproteins as the Diagnostic Target for Cardiovascular Diseases


Affiliations
1 Pushpagiri Research Centre, Pushpagiri Institute of Medical Sciences and Research Centre, Thiruvalla 689 101, India
2 The CHILDS Trust Medical Research Foundation, Chennai 600 034, India
3 Centre for Bio-separation Technology, VIT University, Vellore 632 014, India
 

Low HDL-cholesterol and high LDL-cholesterol in plasma have long been associated with cardiovascular disease (CVD) risk. The quantity of cholesterol associated with these lipoproteins is being traditionally used to predict CVD risk. However, recent studies have suggested that the quality and functionality of these lipoproteins are more important. The lipoproteins - HDL and LDL - undergo both enzymatic and non-enzymatic modifications which impair their functional capability and hence, test of such modification which reflects the quality of HDL can be a good predictor of CVD risk. The present article discusses oxidation- associated dysfunctionality of lipoproteins and their potential in laboratory diagnosis of CVD.

Keywords

Cardiovascular Disease, Cholesterol, Diagnostic Target, Oxidized Lipoproteins.
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  • Oxidized Lipoproteins as the Diagnostic Target for Cardiovascular Diseases

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Authors

S. Sreeja
Pushpagiri Research Centre, Pushpagiri Institute of Medical Sciences and Research Centre, Thiruvalla 689 101, India
Anand Manoharan
The CHILDS Trust Medical Research Foundation, Chennai 600 034, India
Krishnan Venkataraman
Centre for Bio-separation Technology, VIT University, Vellore 632 014, India

Abstract


Low HDL-cholesterol and high LDL-cholesterol in plasma have long been associated with cardiovascular disease (CVD) risk. The quantity of cholesterol associated with these lipoproteins is being traditionally used to predict CVD risk. However, recent studies have suggested that the quality and functionality of these lipoproteins are more important. The lipoproteins - HDL and LDL - undergo both enzymatic and non-enzymatic modifications which impair their functional capability and hence, test of such modification which reflects the quality of HDL can be a good predictor of CVD risk. The present article discusses oxidation- associated dysfunctionality of lipoproteins and their potential in laboratory diagnosis of CVD.

Keywords


Cardiovascular Disease, Cholesterol, Diagnostic Target, Oxidized Lipoproteins.

References





DOI: https://doi.org/10.18520/cs%2Fv115%2Fi7%2F1276-1286