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Anti-Inflammatory Activity of Synthesized Diarylpentenedione Derivatives and their Drug Delivery with Silicon-Nanotube (7,7)


Affiliations
1 School of Electronics, Vignan's Foundation for Science, Technology and Research, Guntur - 522 213, India
2 Department of Biology, Education College, University of Al-Qadisiyah, Al Diwaniyah, Qadisiyyah, Iraq
3 Department of Management Sciences, COMSATS University, Islamabad Vehari Campus, Pakistan
4 Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah 67149-67346, Iraq
 

Earlier studies have confirmed that diarylpentenedione derivaties 1a and 1c have the highest and the lowest anti-inflammatory activity respectively. In this work, the interactions of diarylpentenedione derivatives 1a-1c with Si-nanotube (7,7) were studied and quantum molecular descriptors of the diarylpentenedione derivatives were calculated. Results showed that 1a-1c can interact with Si-nanotube (7,7) significantly and so their adsorptions were possible from an energetic viewpoint. Results also indicated that adsorption thermodynamic values of 1a on Si-nanotube (7,7) were higher than those of 1b and 1c. Therefore 1a has the highest chemical potential and electrophilicity index values. Thus the obtained theoretical and published experimental trends of anti-inflammatory activity of 1a-1c were similar.

Keywords

Adsorption Energy, Anti-Inflammatory and Chemical Potential, Diarylpentenedione Derivatives, Silicon Nanotube.
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  • Anti-Inflammatory Activity of Synthesized Diarylpentenedione Derivatives and their Drug Delivery with Silicon-Nanotube (7,7)

Abstract Views: 442  |  PDF Views: 127

Authors

A. Surendar
School of Electronics, Vignan's Foundation for Science, Technology and Research, Guntur - 522 213, India
S. K. Sadulla
School of Electronics, Vignan's Foundation for Science, Technology and Research, Guntur - 522 213, India
Ali Noory Fajer
Department of Biology, Education College, University of Al-Qadisiyah, Al Diwaniyah, Qadisiyyah, Iraq
Mazhar Abbas
Department of Management Sciences, COMSATS University, Islamabad Vehari Campus, Pakistan
Meysam Najafi
Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah 67149-67346, Iraq

Abstract


Earlier studies have confirmed that diarylpentenedione derivaties 1a and 1c have the highest and the lowest anti-inflammatory activity respectively. In this work, the interactions of diarylpentenedione derivatives 1a-1c with Si-nanotube (7,7) were studied and quantum molecular descriptors of the diarylpentenedione derivatives were calculated. Results showed that 1a-1c can interact with Si-nanotube (7,7) significantly and so their adsorptions were possible from an energetic viewpoint. Results also indicated that adsorption thermodynamic values of 1a on Si-nanotube (7,7) were higher than those of 1b and 1c. Therefore 1a has the highest chemical potential and electrophilicity index values. Thus the obtained theoretical and published experimental trends of anti-inflammatory activity of 1a-1c were similar.

Keywords


Adsorption Energy, Anti-Inflammatory and Chemical Potential, Diarylpentenedione Derivatives, Silicon Nanotube.

References





DOI: https://doi.org/10.18520/cs%2Fv116%2Fi3%2F468-472