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Limonene Attenuates Oxidative Stress and Extends Longevity in Caenorhabditis elegans


Affiliations
1 Microbial Technology and Nematology Department, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow 226 015, India
 

In traditional systems of medicine, plants belonging to the family Rutaceae have been used against ageing and associated debilitating changes. Considering the therapeutic potential of limonene (C10H16), the principal component of the Rutaceae family plants, the present study was designed to decipher lifespan and stress-modulating potential of monocyclic terpene limonene (LM) employing genetically tractable model system Caenorhabditis elegans. Furthermore, we tested oxidative stress tolerance and in vivo reactive oxygen species build-up, which was monitored with or without exposure to LM. Additionally, involvement of transcription factor DAF-16 was examined in terms of nuclear localization. Overall, this study has implications for developing future anti-ageing pharmacological strategies in the future.

Keywords

Ageing, Caenorhabditis elegans, Limonene, Oxidative Stress.
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  • Limonene Attenuates Oxidative Stress and Extends Longevity in Caenorhabditis elegans

Abstract Views: 336  |  PDF Views: 119

Authors

Pooja Shukla
Microbial Technology and Nematology Department, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow 226 015, India
Aakanksha Pant
Microbial Technology and Nematology Department, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow 226 015, India
Rakesh Pandey
Microbial Technology and Nematology Department, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow 226 015, India

Abstract


In traditional systems of medicine, plants belonging to the family Rutaceae have been used against ageing and associated debilitating changes. Considering the therapeutic potential of limonene (C10H16), the principal component of the Rutaceae family plants, the present study was designed to decipher lifespan and stress-modulating potential of monocyclic terpene limonene (LM) employing genetically tractable model system Caenorhabditis elegans. Furthermore, we tested oxidative stress tolerance and in vivo reactive oxygen species build-up, which was monitored with or without exposure to LM. Additionally, involvement of transcription factor DAF-16 was examined in terms of nuclear localization. Overall, this study has implications for developing future anti-ageing pharmacological strategies in the future.

Keywords


Ageing, Caenorhabditis elegans, Limonene, Oxidative Stress.

References





DOI: https://doi.org/10.18520/cs%2Fv116%2Fi6%2F959-965