Current Science

Open Access Open Access  Restricted Access Subscription Access

Study the Effect of Star Anise Extract and the Pulp of Kiwifruit on Mice Infected with Cancer


Affiliations
1 Department of Food Science and Nutrition, Taif University, Taif–Al-Haweiah, P. O. Box 888, ZIP code 21974, Taif, Saudi Arabia
2 Department of Nutrition and Food Science, Al Azhar University, Egypt
 

The antitumour activity of kiwifruit juice (K), star anise decoction (SA) and their mixture as nutritional treatment was studied in mice with Ehrlich ascites carcinoma (EAC). Female Swiss albino mice were treated by oral feeding with kiwifruit juice (1 ml/ mice), star anise decoction (1 ml/mice) and their mixture (1 ml/mice) for 14 consecutive days. Cisplatin drug was injected two times (10 mg/mice i.p.) on the fifth and seventh days. The results showed that kiwifruit and star anise as nutritional sources helped to bring back serum levels of AST and ALT enzymes and creatinine activities. Kiwifruit and star anise decreased tumour cell count and brought back the haematological data to near normal levels, arresting the cell cycle at normal phases.

Keywords

Cancer, Cell Cycle, Kiwifruit, Mice, Star Anise.
User
Notifications
Font Size

  • Abdullaev, F. I., Una, R. R., Roitenburd, B. V. and Espinosa, A. J., Pattern of childhood cancer mortality in Mexico. Arch. Med. Res., 2000, 31, 526–531.

  • Babasaheb, P. B., Shrikant, S. G., Ragini, G. B., Jalinder, V. T. and Chandrahas, N. K., Synthesis and biological evaluation of simple methoxylated chalcones as anticancer, anti-inflammatory and antioxidant agents. Bioorg. Med. Chem., 2010, 18, 1364– 1370.

  • Samanta, S. M., Alam, M., Basu, S., Maji, T., Roy, D. K. and Jha, T., Chemotherapeutic approach to prolonged survival time in combination with immunization and glutamic acid derivatives with anti-tumor activity in tumor-bearing mice. Biol. Pharm. Bull., 2007, 30, 2334–2339.

  • Sleman, K., Mahmoud, R. and Anwar, R., Anticancer activity of anise (Pimpinella anisum L.) seed extract. Open Nutraceut. J., 2013, 6, 1–5.

  • Paola, B. et al., Nutrient dietary patterns and gastric cancer risk in Italy. Cancer Epidemiol. Biomarkers Prev., 2009, 18, 2882– 2886.

  • Hilal, Z., Anwar, R., Omar, S. and Bashar, S., Cancer Treatment by Greco-Arab and Islamic herbal medicine. Open Nutraceut. J., 2010, 3, 203–212.

  • Wieland, P. et al., An industrial approach in the search of natural antioxidants from vegetable and fruit wastes. Food Chem., 2006, 97, 137–150.

  • 8. Guroo, I, Wani, S., Wani, S., Ahmad, M., Mir, S. and Masoodi, F. A., Review of production and processing of kiwifruit. J. Food Proc. Technol., 2017, 8, 1–6.

  • Jiangsu New Medicine College, Dictionary of Chinese Traditional Medicines, Shanghai Science and Technology Press, Shanghai, China, 1984, 2205.

  • Ichiro, N., Yuka, Y., Miho, Y., Atsuko, S., Tetsuo, F. and Tadachika, O., Varietal difference in vitamin C content in the fruit of kiwifruit and other Actinidia species. J. Agric. Food Chem., 2004, 52, 5472–5475.

  • Guorong, D., Mingjun, L., Fengwang, M. and Dong, L., Antioxidant capacity and the relationship with polyphenols and vitamin C in Actinidia fruits. Food Chem., 2009, 113, 557–562.

  • Silvia, T., Elena D., Damiano, R., Rossano, M. and Lucia, G., Antioxidant capacity, ascorbic acid, total phenols and carotenoids changes during harvest and after storage of Hayward kiwifruit. Food Chem., 2008, 107, 282–288.

  • Collins, B., Horska, A., Hotten, P., Riddoch, C. and Collins, A., Kiwifruit protects against oxidative DNA damage in human cells in vitro. Nutr. Cancer, 2001, 39, 148–153.

  • Wei, L., Hua, R., Li, M., Huang, Y., Li, S., He, Y. and Shen, Z., Chemical composition and biological activity of star anise Illicium verum extracts against maize weevil, Sitophilus zeamais adults. J. Insect Sci., 2014, 14, 1–13.

  • Padmashree, A., Roopa, N., Semwal, A., Sharma, G., Agathian, G. and Bawa, A., Star-anise (Illicium verum) and black caraway (Carum nigrum) as natural antioxidants. Food Chem., 2007, 104, 59–66.

  • Cheng-Hong, Y., Fang-Rong, C., Hsueh-Wei, C., Shao-Ming, W., Ming-Che, H. and Li-Yeh, C., Investigation of the antioxidant activity of Illicium verum extracts. J. Med. Plants Res., 2012, 6, 314–324.

  • Pe´rez-Jime´nez, J., Neveu, V., Vos, F. and Scalbert, A., Identification of the 100 richest dietary sources of polyphenols: an application of the Phenol-Explorer database. Eur. J. Clin. Nutr., 2010, 64, 112–120.

  • Cai, Y., Luo, Q., Sun, M. and Corke, H., Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancer. Life Sci., 2004, 74, 2157–2184.

  • Sohair, R. F. and Khadiga, G., Establishing the first institutional animal care and use committee in Egypt. Philos., Ethics Hum. Med., 2016, 11, 1–6.

  • Lala, P. K., Santer, V. and Rahil, K. S., Spontaneous fusion between Ehrlich ascites tumor cells and host cells in vivo: kinetics of hybridization, and concurrent changes in the histocompatiblity profile of the tumor after propagation in different host strains. Eur. J. Cancer, 1980, 16, 487–510.

  • Drury, R. A. and Wallington, E. A., Carton’s Histological Technique, Oxford University Press, New York, USA, 1980, 5th edn.

  • Reitman, S. and Frankel, S., A colorimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transaminases. Am. J. Clin. Pathol., 1957, 28, 28–56.

  • Roy, W. B. and Hertha, H. T., On the colorimetric determination of creatinine by the Jaffe reaction. J. Biol. Chem., 1945, 10, 581– 591.

  • Lou, Y. et al., Dendritic cells strongly boost the antitumor activity of adoptively transferred T cells in vivo. Cancer Res., 2004, 64, 6783–6790.

  • Kathiriya, A., Das, K., Kumar, E. P. and Mathai, K. B., Evaluation of antitumor and antioxidant activity of Oxalis corniculata Linn. against Ehrlich ascites carcinoma on mice. Iran J. Cancer Prev., 2010, 3, 157–165.

  • Rubinstein, M. P., Kadima, A. N., Salem, M. L., Nguyen, C. L., Gillanders, W. E. and Cole, D. J., Systemic administration of IL15 augments the antigen-specific primary CD8+ T cell response following vaccination with peptide-pulsed dendritic cells. J. Immunol., 2002, 169, 4928–4935.

  • Lutz, M., Kukutsch N., Ogilvie A., Rossner, S., Koch, F., Romani, N. and Schuler, G., An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. J. Immunol. Methods, 1999, 223, 77–92.

  • Díaz-Montero, C. M., El Naggar, S., Al Khami, A., El Naggar, R., Montero, A. J., Cole, D. J. and Salem, M. L., Priming of naive cells in the a presence of IL-12 selectively enhances the survival of CD8+CD62 Lhi cells and results in superior anti-tumor activity in a tolerogenic murine model. Cancer Immunol. Immunother., 2008, 57, 563–572.

  • Afrah, F., Mohamed, L., Wafaa, M. and Yara, A. Nicotinic acid inducing G0/G1 cell cycle arrest and apoptosis in Ehrlich ascites carcinoma cells in vivo. Alex. J. Veter. Sci., 2017, 53, 79–87.

  • Armitage, P. and Berry, G., Statistical Methods in Meckwell, Oxford, UK, 1987, pp. 93–213.

  • Shipra, P., Arpita, S. S., Swarup, P. and Kalyan, K. M., Histological vis-à-vis biochemical assessment on the toxic level and antineoplastic efficacy of a synthetic drug Pt-ATP on experimental animal models. J. Exp. Clin. Cancer Res., 2008, 27, 1–8.

  • Abdel-Moneim, M. et al., Dimethylsulfoxide exacerbates cisplatin induced cytotoxicity in Ehrlich ascites carcinoma cells. Cancer Cell Int., 2015, 15, 1–9.

  • Attia, W., Gabry, M., El-Shaikh, K. and Othman, G., The antitumor effect of bee honey in Ehrlich ascite tumor model of mice is coincided with stimulation of the immune cells. Egypt. J. Immunol., 2008, 15, 169–183.

  • Muralidhar, A., Somasekhar, A., Sumanjali, A., Praveen, B., Lakshmi, B., Shahdul T. and Bhargavi, D., Anticancer activity of Tephrosia purpurea ischolar_main extracts against Ehrlich ascites carcinoma (EAC) cells in Swiss albino mice. Pelagia Res. Lib., 2014, 5, 81–87.

  • Ahmed, H., Ragaa, H. Al Tahtawy, F. and Amr, M., Antitumor and antioxidant activity of honey in mice bearing Ehrlich ascites carcinoma. Acad. J. Cancer Res., 2014, 7, 208–214.

  • Fenninger, L. and Mider, G., Energy and nitrogen metabolism in cancer. In Advances in Cancer Research (eds Grenstein, J. P. and Haddow, A.), Academic Press, New York, USA, 1954, vol. 2, p. 244.

  • Beck, K., Conlon, C., Kruger, R., Coad, J. and Stonehouse, W., Gold Kiwifruit consumed with an iron-fortified breakfast cereal meal improves iron status in women with low iron stores: a 16week randomized controlled trial. Br. J. Nutr., 2011, 105, 101– 109.

  • Carr, A. and Frei, B., Does vitamin C act as a pro-oxidant under physiological conditions? FASEB J., 1999, 13, 1007–1024.

  • Amani, F. H., Noureldeen, Hana, M., Gashlan, Nuha, A., Al-Ghamdi and Ramadan, M., In vivo antitumor activity of bis (4bromobenzaldehyde-4-iminacetophenone) tetraaquochromium (III) sulphate complex against Ehrlich ascites carcinoma cells induced in mice. Res. J. Pharma. Biol. Chem. Sci., 2017, 8, 1406–1414.

  • Déborah, R. et al., Toxicity and antitumor efficacy of Croton polyandrus oil against Ehrlich ascites carcinoma cells. Rev. Bras. Farmacogn., 2016, 26, 751–758.

  • Srivastava, S. et al., Quercetin, a natural flavonoid Interacts with DNA, arrests cell cycle and causes tumor regression by activating mitochondrial pathway of apoptosis. Sci. Rep., 2016, 6, 240–249.

  • Safarzadeh, E., Shotorbani, S. and Baradaran, B., Herbal medicine as inducers of apoptosis in cancer treatment. Adv. Pharm. Bull., 2014, 4, 421–427.

  • Fukumasu, H., Latorre, A. O. and Zaidan-Dagli, M. L., Paullinia cupana Mart. var. sorbilis, guarana, increases survival of Ehrlich ascites carcinoma (EAC) bearing mice by decreasing cyclin-D1 expression and inducing a G0/G1 cell cycle arrest in EAC cells. Phytother. Res., 2011, 25, 11–16.

  • Kabir, S. R., Nabi, M. M., Haque, A., Rokon, U. Z., Mahmud, Z. H. and Reze, M. A., Pea lectin inhibits growth of Ehrlich ascites carcinoma cells by inducing apoptosis and G2/M cell cycle arrest in vivo in mice. J. Phytomed., 2013, 20, 1288–1296.

  • Collins, A., Harrington, V., Drew, J. and Melvin, R., Nutritional modulation of DNA repair in a human intervention study. J. Carcinogen., 2003, 24, 511–515.

  • Dinesha, R., Thammannagowda, S., Shwetha, K., Prabhu, M., Madhu, C. and Leela, S., The antioxidant and DNA protectant activities of star anise (Illicium verum) aqueous extracts. J. Pharmacogn. Phytochem., 2014, 2, 98–103.

  • Subhasree, B., Baskar, R., Laxmi, R., Lijina, R. and Rajasekaran, P., Evaluation of antioxidant potential in selected green leafy vegetables. Food Chem., 2009, 115, 1213–1220.

  • Antonio, F. et al., Tocomonoenol: a new vitamin E from kiwi (Actinidia chinensis) fruits. Food Chem., 2009, 115, 187–192.

  • Carr, A., Bozonet, S., Pullar, J., Simcock, J. and Vissers, M., Human skeletal muscle ascorbate is highly responsive to changes in vitamin C intake and plasma concentrations. Am. J. Clin. Nutr., 2013, 94, 800–807.

  • Mandl, J., Szarka, A. and Banhegyi, G., Vitamin C: update on physiology and pharmacology. Br. J. Pharmacol., 2009, 157, 1097–1110.

  • German Nutrition Society (DGE), Bonn, Germany, New reference values for vitamin C intake. Ann. Nutr. Metab., 2015, 67, 13–20.

  • You, J., Chang-Sik, O., Youn-Doo, P., Seok, H., Dae-Ok, K., Ung-Jin, K. and Youn-Sup, C., Physiological components of kiwifruits with in vitro antioxidant and acetylcholinesterase inhibitory activities. Food Sci. Biotechnol., 2014, 23, 943–949.

  • Lilei, Y., Anne-Laure, N. and Trust, B., Comparison of wheat flours grown at different locations for their antioxidant properties. Food Chem., 2004, 86, 11–16.

  • David, P., Juliet, A. and Lynley, N., The nutritional and health attributes of kiwifruit: a review. Eur. J. Nutr., 2018, 57, 2659– 2676.

  • Sachin, T., Nanher, A., Sanjay, S., Vikash, K., Kanchan, B., Subodh, K. and Mukhtar, A., Kiwifruit: health benefits and medicinal importance. Rashtriya Krishi, 2015, 10, 98–100.

  • Huma, A. et al., Protocatecheuic acid underlies the antioxidant activity exhibited by Illicium verum fruit. J. Anal. Pharm. Res., 2017, 6, 1–5.

  • Bharat, B., Ajaikumar, B., Kuzhuvelil, B., Sheeja, T., Bokyung, S. and Preetha, A., Potential of spice-derived phytochemicals for cancer prevention. Planta Med., 2008, 74, 1560–1569.

  • Yadav, A. and Bhatnagar, D., Chemo-preventive effect of star anise in N-nitrosodiethylamine initiated and phenobarbital promoted hepatocarcinogenesis. Chem. Biol. Interact., 2007, 169, 207–214.

  • Aggarwal, B., Kunnumakkara, A., Harikumar, K., Tharakan, S., Sung, B. and Anand, P., Potential of spice-derived phytochemicals for cancer prevention. Planta Med., 2008, 74, 1560–1569.


Abstract Views: 470

PDF Views: 128




  • Study the Effect of Star Anise Extract and the Pulp of Kiwifruit on Mice Infected with Cancer

Abstract Views: 470  |  PDF Views: 128

Authors

Dalia I. Hemdan
Department of Food Science and Nutrition, Taif University, Taif–Al-Haweiah, P. O. Box 888, ZIP code 21974, Taif, Saudi Arabia
Nabila Y. Mahmoud Abdulmaguid
Department of Nutrition and Food Science, Al Azhar University, Egypt

Abstract


The antitumour activity of kiwifruit juice (K), star anise decoction (SA) and their mixture as nutritional treatment was studied in mice with Ehrlich ascites carcinoma (EAC). Female Swiss albino mice were treated by oral feeding with kiwifruit juice (1 ml/ mice), star anise decoction (1 ml/mice) and their mixture (1 ml/mice) for 14 consecutive days. Cisplatin drug was injected two times (10 mg/mice i.p.) on the fifth and seventh days. The results showed that kiwifruit and star anise as nutritional sources helped to bring back serum levels of AST and ALT enzymes and creatinine activities. Kiwifruit and star anise decreased tumour cell count and brought back the haematological data to near normal levels, arresting the cell cycle at normal phases.

Keywords


Cancer, Cell Cycle, Kiwifruit, Mice, Star Anise.

References





DOI: https://doi.org/10.18520/cs%2Fv118%2Fi1%2F87-93