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Study the Effect of Star Anise Extract and the Pulp of Kiwifruit on Mice Infected with Cancer


Affiliations
1 Department of Food Science and Nutrition, Taif University, Taif–Al-Haweiah, P. O. Box 888, ZIP code 21974, Taif, Saudi Arabia
2 Department of Nutrition and Food Science, Al Azhar University, Egypt
 

The antitumour activity of kiwifruit juice (K), star anise decoction (SA) and their mixture as nutritional treatment was studied in mice with Ehrlich ascites carcinoma (EAC). Female Swiss albino mice were treated by oral feeding with kiwifruit juice (1 ml/ mice), star anise decoction (1 ml/mice) and their mixture (1 ml/mice) for 14 consecutive days. Cisplatin drug was injected two times (10 mg/mice i.p.) on the fifth and seventh days. The results showed that kiwifruit and star anise as nutritional sources helped to bring back serum levels of AST and ALT enzymes and creatinine activities. Kiwifruit and star anise decreased tumour cell count and brought back the haematological data to near normal levels, arresting the cell cycle at normal phases.

Keywords

Cancer, Cell Cycle, Kiwifruit, Mice, Star Anise.
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  • Study the Effect of Star Anise Extract and the Pulp of Kiwifruit on Mice Infected with Cancer

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Authors

Dalia I. Hemdan
Department of Food Science and Nutrition, Taif University, Taif–Al-Haweiah, P. O. Box 888, ZIP code 21974, Taif, Saudi Arabia
Nabila Y. Mahmoud Abdulmaguid
Department of Nutrition and Food Science, Al Azhar University, Egypt

Abstract


The antitumour activity of kiwifruit juice (K), star anise decoction (SA) and their mixture as nutritional treatment was studied in mice with Ehrlich ascites carcinoma (EAC). Female Swiss albino mice were treated by oral feeding with kiwifruit juice (1 ml/ mice), star anise decoction (1 ml/mice) and their mixture (1 ml/mice) for 14 consecutive days. Cisplatin drug was injected two times (10 mg/mice i.p.) on the fifth and seventh days. The results showed that kiwifruit and star anise as nutritional sources helped to bring back serum levels of AST and ALT enzymes and creatinine activities. Kiwifruit and star anise decreased tumour cell count and brought back the haematological data to near normal levels, arresting the cell cycle at normal phases.

Keywords


Cancer, Cell Cycle, Kiwifruit, Mice, Star Anise.

References





DOI: https://doi.org/10.18520/cs%2Fv118%2Fi1%2F87-93