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Deciphering Asymptomatic Malaria–The Missing Link in India’s Fight against the Disease?


Affiliations
1 Malaria Division, ICMR-RMRC Northeast Region, Dibrugarh 786 001, India
2 DBT-Ramalingaswami Re-entry Fellowship, ICMR-RMRC Northeast Region, Dibrugarh 786 001, India
 

According to the World Malaria Report 2019, there has been a reduction in malaria cases worldwide by approximately 23 million during 2010–18 (ref. 1). However, data does not suggest a significant case reduction from 2017 to 2018 globally. India, interestingly, showed a reduction of 2.6 million malaria cases in 2018 compared to 2017 (ref. 1). This is encouraging since most other high-burden African countries reported an increase in disease burden. As India moves towards its goal of malaria elimination by 2030, the focus has shifted to controlling hidden and underexplored niches of infection such as asymptomatic and sub- microscopic malaria. Studies conducted across different epidemiological settings in India over the past few years roughly peg the asymptomatic malaria burden anywhere between 18% and 71% (ref. 2). Identification of these cases, accurate diagnosis and evaluation of their actual role in persistence and transmission of the malaria parasite present unique challenges.
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  • WHO, World Malaria Report 2019. World Health Organization, Geneva, Switzerland, 2019.

  • Van Eijk, A. M. et al., Sci. Rep., 2019, 9(1), 17095.

  • Ouedraogo, A. L. et al., J. Infect. Dis., 2016, 213(1), 90–99.

  • Lin, J. T., Saunders, D. L. and Meshnick, S. R., Trends Parasitol., 2014, 30(4), 183–190.

  • Ouedraogo, A. L. et al., Malar. J., 2010, 9, 281.

  • Bousema, T. et al., Malar. J., 2010, 9, 136.

  • Meibalan, E. and Marti, M., Cold Spring Harb. Perspect. Med., 2017, 7(3).

  • Vallejo, A. F., Garcia, J., Amado-Garavito, A. B., Arevalo-Herrera, M. and Herrera, S., Malar. J., 2016, 15, 48.

  • Martins-Campos, K. M. et al., Parasit. Vectors, 2018, 11(1), 288.

  • Lindblade, K. A., Steinhardt, L., Samuels, A., Kachur, S. P. and Slutsker, L., Expert Rev. Anti-infect. Ther., 2013, 11(6), 623–639.


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  • Deciphering Asymptomatic Malaria–The Missing Link in India’s Fight against the Disease?

Abstract Views: 467  |  PDF Views: 128

Authors

Saurav Jyoti Patgiri
Malaria Division, ICMR-RMRC Northeast Region, Dibrugarh 786 001, India
Dibya Ranjan Bhattacharyya
Malaria Division, ICMR-RMRC Northeast Region, Dibrugarh 786 001, India
Ipsita Pal Bhowmick
Malaria Division, ICMR-RMRC Northeast Region, Dibrugarh 786 001, India
Md Atique Ahmed
DBT-Ramalingaswami Re-entry Fellowship, ICMR-RMRC Northeast Region, Dibrugarh 786 001, India

Abstract


According to the World Malaria Report 2019, there has been a reduction in malaria cases worldwide by approximately 23 million during 2010–18 (ref. 1). However, data does not suggest a significant case reduction from 2017 to 2018 globally. India, interestingly, showed a reduction of 2.6 million malaria cases in 2018 compared to 2017 (ref. 1). This is encouraging since most other high-burden African countries reported an increase in disease burden. As India moves towards its goal of malaria elimination by 2030, the focus has shifted to controlling hidden and underexplored niches of infection such as asymptomatic and sub- microscopic malaria. Studies conducted across different epidemiological settings in India over the past few years roughly peg the asymptomatic malaria burden anywhere between 18% and 71% (ref. 2). Identification of these cases, accurate diagnosis and evaluation of their actual role in persistence and transmission of the malaria parasite present unique challenges.

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DOI: https://doi.org/10.18520/cs%2Fv118%2Fi9%2F1333-1334