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Membrane-bound proteins integrate and coordinate various signalling activities to maintain tissue architecture. In recent years, research updates indicate that these proteins undergo post-translational modification like glycosylation to maintain tissue integrity. Here we discuss research updates from Drosophila, about two essential membrane-bound proteins, Notch and Crumbs, that undergo such modifications to interact with each other and their implications in tumorigenesis

Keywords

Epidermal-Growth-Factor Repeats, Glycosyltransferases, Membrane-Bound Proteins, Tumorigenesis, Xylosylation.
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