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Medicinal plants with kidney-protecting effect in diabetic nephropathy


Affiliations
1 Department of Medical Biotechnology, Sikkim Manipal Institute of Medical Sciences, Sikkim Manipal University, 5th Mile, Tadong, Gangtok 737 102, India
2 Department of Medicine, Sikkim Manipal Institute of Medical Sciences, Sikkim Manipal University, 5th Mile, Tadong, Gangtok 737 102, India
 

Diabetic nephropathy (DN) is a progressive kidney disease, which may often lead to end-stage renal diseases. DN is becoming more prevalent due to the increase in the incidences of diabetes. Controlling blood glucose levels can inhibit DN, but a significant fraction of the diabetic population can develop DN despite glycemic control. Therefore, identification of new drug molecules that can prevent or ameliorate DN by directly acting on the kidney would be a breakthrough in its manage­ment. Medicinal plants offer a vast repository of potential therapeutic agents for several diseases, including diabetes and its complications. A good number of plants have been studied for their kidney-protecting effects on DN. This article summarizes the active compounds and mechanisms by which these plants protect the kidney in diabetic conditions. The majority of the studies are found for animal models. Clinical trials are available only for a few plants, which are also included in this article
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  • Medicinal plants with kidney-protecting effect in diabetic nephropathy

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Authors

Arundhati Bag
Department of Medical Biotechnology, Sikkim Manipal Institute of Medical Sciences, Sikkim Manipal University, 5th Mile, Tadong, Gangtok 737 102, India
Abhiskek Byahut
Department of Medical Biotechnology, Sikkim Manipal Institute of Medical Sciences, Sikkim Manipal University, 5th Mile, Tadong, Gangtok 737 102, India
Bidita Khandelwal
Department of Medicine, Sikkim Manipal Institute of Medical Sciences, Sikkim Manipal University, 5th Mile, Tadong, Gangtok 737 102, India

Abstract


Diabetic nephropathy (DN) is a progressive kidney disease, which may often lead to end-stage renal diseases. DN is becoming more prevalent due to the increase in the incidences of diabetes. Controlling blood glucose levels can inhibit DN, but a significant fraction of the diabetic population can develop DN despite glycemic control. Therefore, identification of new drug molecules that can prevent or ameliorate DN by directly acting on the kidney would be a breakthrough in its manage­ment. Medicinal plants offer a vast repository of potential therapeutic agents for several diseases, including diabetes and its complications. A good number of plants have been studied for their kidney-protecting effects on DN. This article summarizes the active compounds and mechanisms by which these plants protect the kidney in diabetic conditions. The majority of the studies are found for animal models. Clinical trials are available only for a few plants, which are also included in this article

References





DOI: https://doi.org/10.18520/cs%2Fv123%2Fi4%2F542-553