Current Science

Open Access Open Access  Restricted Access Subscription Access

Synthesis, Characterization, Antioxidant and Antibacterial Studies of Praseodymium Complex with Glutathione


Affiliations
1 Department of Chemistry, Nagaland University, Lumami 798 627, India
 

Reduced glutathione (GSH) is a biologically important component that plays a critical role in antioxidant activity. Praseodymium(III) complex with GSH was synthesized and the complex formed was characterized by FTIR, XRD, TGA and SEM analysis. Infrared studies provided information on the mode of complexation between the lanthanide metal ion and GSH. XRD and TEM analysis showed the nanocrystalline phase and irregular morphology of the complex. TGA thermogram indicated good thermal stability of the complex. The in vitro antioxidant and antibacterial properties of the complex were studied. The results suggest that the praseodymium(III) complex possesses antioxidant and antibacterial activity.

Keywords

Antibacterial and Antioxidant Activity, Glutathi-One, Lanthanide, Praseodymium Complex.
User
Notifications
Font Size

  • Bernot, K., Daiguebonne, C., Calvez, G., Suffren, Y. and Guillou, O., A journey in lanthanide coordination chemistry: from evaporable dimers to magnetic materials and luminescent devices. Acc. Chem. Res., 2021, 207, 427–440.

  • Chundawat, N. S., Jadoun, S., Zarrintaj, P. and Chauhan, N. P. S., Lanthanide complexes as anticancer agents: a review. Polyhedron, 2021, 207, 115387.

  • Gassner, A. L., Duhot, C., Bünzli, J. C. G. and Chauvin, A. S., Remarkable tuning of the photophysical properties of bifunctional lanthanide tris(dipicolinates) and its consequence on the design of bioprobes. Inorg. Chem., 2008, 47, 7802–7812.

  • Li, H., Wang, X., Ohulchanskyy, T. Y. and Chen, G., Lanthanide-doped near-infrared nanoparticles for biophotonics. Adv. Mater., 2021, 33, 2000678.

  • Bünzli, J. C. G., Luminescence bioimaging with lanthanide complexes. In Luminescence of Lanthanide Ions in Coordination Compounds and Nanomaterials (ed. Bettencourt-Dias, A. de), Wiley, USA, 2014, pp. 125–196.

  • Fricker, S. P., The therapeutic application of lanthanides. Chem. Soc. Rev., 2006, 35, 524–533.

  • Abdus Subhan, M., Saifur Rahman, M., Alam, K. and Mahmud Hasan, M., Spectroscopic analysis, DNA binding and antimicrobial activities of metal complexes with phendione and its derivative. Spectrochim. Acta – Part A, 2014, 118, 944–950.

  • Wu, G., Fang, Y. Z., Yang, S., Lupton, J. R. and Turner, N. D., Glutathione metabolism and its implications for health. J. Nutr., 2004, 134, 489–492.

  • Noctor, G., Queval, G., Mhamdi, A., Chaouch, S. and Foyer, C. H., Glutathione. Tanpakushitsu Kakusan Koso, 1988, 33, 1353–1654.

  • Richa, K., Karmaker, R., Ao, T., Longkumer, N., Singha, B. and Sinha, U. B., Rationale for antioxidant interaction studies of 4-bromo-1-isothiocyanato-2-methylbenzene – an experimental and computational investigation. Chem. Phys. Lett., 2020, 753, 137611.

  • Jain, S. and Mehata, M. S., Medicinal plant leaf extract and pure flavonoid mediated green synthesis of silver nanoparticles and their enhanced antibacterial property. Sci. Rep., 2017, 7, 15867.

  • Selim, M., Saha, A. and Mukherjea, K. K., Synthesis, characterization, and DNA binding of the biologically relevant novel cationic molybdenum(VI)–glutathione complex [Mo(GS)(Cl)(H2O)]Cl2. Monatsh. Chem., 2012, 143, 227–233.

  • Han, G. C. and Liu, Y. N., Synthesis, characterization and fluorescent properties of cerium(III) glutathione complex. Luminescence, 2010, 25, 389–393.

  • Ahmad, S., Hanif, M., Monim-Ul-Mehboob, M., Isab, A. A. and Ahmad, S., Silver(I) complexation with glutathione in the presence of tetramethylthiourea. Synth. React. Inorg., Met. Nano-Met. Chem., 2009, 39, 45–49.

  • Pisoschi, A. M. and Pop, A., The role of antioxidants in the chemistry of oxidative stress: a review. Eur. J. Med. Chem., 2015, 97, 55–74.

  • Nimse, S. B. and Pal, D., Free radicals, natural antioxidants, and their reaction mechanisms. RSC Adv., 2015, 5, 27986–28006.

  • Cai, Y., Sun, M. and Corke, H., Antioxidant activity of betalains from plants of the amaranthaceae. J. Agric. Food Chem., 2003, 51, 2288–2294.

  • Benzie, I. F. F. and Strain, J. J., The ferric reducing ability of plasma (FRAP) as a measure of ‘antioxidant power’: the FRAP assay. Anal. Biochem., 1996, 239, 70–76.

  • Zhong, Y. and Shahidi, F., Methods for the assessment of antioxidant activity in foods. In Handbook of Antioxidants for Food Preservation (ed. Shahidi, F.), Woodhead Publishing, Cambridge, UK, 2015, pp. 287–333.

  • Berker, K. I., Gülü, K., Demirata, B. and Apak, R., A novel antioxidant assay of ferric reducing capacity measurement using ferrozine as the colour forming complexation reagent. Anal. Methods, 2010, 2, 1770–1778.

  • Cota, I., Marturano, V. and Tylkowski, B., Ln complexes as double faced agents: study of antibacterial and antifungal activity. Coord. Chem. Rev., 2019, 396, 49–71.

  • Tweedy, B. G., Plant extracts with metal ions as potential anti-microbial agents. Phytopatology, 1964, 55, 910–918.


Abstract Views: 268

PDF Views: 126




  • Synthesis, Characterization, Antioxidant and Antibacterial Studies of Praseodymium Complex with Glutathione

Abstract Views: 268  |  PDF Views: 126

Authors

Mhasiriekho Ziekhrü
Department of Chemistry, Nagaland University, Lumami 798 627, India
Putusenla Imchen
Department of Chemistry, Nagaland University, Lumami 798 627, India
Tovishe Phucho
Department of Chemistry, Nagaland University, Lumami 798 627, India
M. Indira Devi
Department of Chemistry, Nagaland University, Lumami 798 627, India

Abstract


Reduced glutathione (GSH) is a biologically important component that plays a critical role in antioxidant activity. Praseodymium(III) complex with GSH was synthesized and the complex formed was characterized by FTIR, XRD, TGA and SEM analysis. Infrared studies provided information on the mode of complexation between the lanthanide metal ion and GSH. XRD and TEM analysis showed the nanocrystalline phase and irregular morphology of the complex. TGA thermogram indicated good thermal stability of the complex. The in vitro antioxidant and antibacterial properties of the complex were studied. The results suggest that the praseodymium(III) complex possesses antioxidant and antibacterial activity.

Keywords


Antibacterial and Antioxidant Activity, Glutathi-One, Lanthanide, Praseodymium Complex.

References





DOI: https://doi.org/10.18520/cs%2Fv124%2Fi5%2F554-561