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Simulation Study on the Photoacoustics of Cells with Endocytosed Gold Nanoparticles


Affiliations
1 Surface Physics and Material Science Division, Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata 700 064, India
 

The effect of endocytosis of gold nanoparticles (AuNPs) on photoacoustic (PA) signal is examined using computer simulations. It assumes that the endocytosed AuNPs significantly enhance cellular optical absorption but do not alter thermophysical parameters. The PA signals were computed employing a theoretical model at various cell and intracellular NP concentrations for 532 nm illumination. It was found that the PA amplitude increased linearly in both the cases. The simulation results, when the contributions from both coherent and incoherent components are included, demonstrate good agreement with published experimental results.

Keywords

Computer Simulations, Endocytosis, Gold Nanoparticles, Photoacoustic Signals.
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  • Simulation Study on the Photoacoustics of Cells with Endocytosed Gold Nanoparticles

Abstract Views: 404  |  PDF Views: 123

Authors

Ratan K. Saha
Surface Physics and Material Science Division, Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata 700 064, India
Madhusudan Roy
Surface Physics and Material Science Division, Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata 700 064, India
Alokmay Datta
Surface Physics and Material Science Division, Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata 700 064, India

Abstract


The effect of endocytosis of gold nanoparticles (AuNPs) on photoacoustic (PA) signal is examined using computer simulations. It assumes that the endocytosed AuNPs significantly enhance cellular optical absorption but do not alter thermophysical parameters. The PA signals were computed employing a theoretical model at various cell and intracellular NP concentrations for 532 nm illumination. It was found that the PA amplitude increased linearly in both the cases. The simulation results, when the contributions from both coherent and incoherent components are included, demonstrate good agreement with published experimental results.

Keywords


Computer Simulations, Endocytosis, Gold Nanoparticles, Photoacoustic Signals.



DOI: https://doi.org/10.18520/cs%2Fv106%2Fi11%2F1554-1559