![Open Access](https://i-scholar.in/lib/pkp/templates/images/icons/fulltextgreen.png)
![Restricted Access](https://i-scholar.in/lib/pkp/templates/images/icons/fulltextred.png)
Interaction of Glycyrrhizin with Human Haemoglobin
This study investigates interaction of glycyrrhizin (an herbal therapeutic agent) with human haemoglobin. The interaction is confirmed by glycyrrhizin-induced quenching of absorbance and fluorescence data. Both hydrophobic and electrostatic interactions appear to be involved in glycyrrhizin-haemoglobin binding. The binding causes no change in the secondary structure of haemoglobin. The interaction decreases H2O2- induced iron release from haemoglobin and haemoglobin- mediated oxidative reactions. Glycyrrhizin inhibits ferryl-haemoglobin formation, peroxidase and esteraselike activities of the heme protein. Almost no oxygen is released from haemoglobin due to glycyrrhizin binding. The interaction thus reduces haemoglobin-mediated oxidative damage without affecting oxygen-binding capacity of the protein, and may be an advantage in therapeutic application of glycyrrhizin.
Keywords
Free Iron, Glycyrrhizin, Haemoglobin, Oxidative Stress.
User
Font Size
Information
![](https://i-scholar.in/public/site/images/abstractview.png)
Abstract Views: 309
![](https://i-scholar.in/public/site/images/pdfview.png)
PDF Views: 126