Current Science

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We studied the effect of 1,25-dihydroxy vitamin D3 [1,25(OH)2D,3] on toll-like receptor (TLR) gene expression in neutrophils cultured with Mycobacterium tuberculosis (Mtb) with or without 1,25(OH)2D3 in pulmonary tuberculosis patients and healthy controls. 1,25(OH)2D3 significantly increased the expression of TLR2, TLR9 and TIRAP genes compared to control cells in both the study groups (P < 0.05). In healthy controls, a significantly upregulated expression of TIRAP was observed in Mtb infected cells cultured with 1,25(OH)2D3 compared to Mtb infected cells alone (P < 0.05). In conclusion, 1,25(OH)2D3 upregulated the expression of TLR and TIRAP genes, which could lead to the activation of TLR signalling pathways and augment the innate immunity to tuberculosis.

Keywords

Gene Expression, Neutrophils, Tuberculosis, Toll-like Receptors.
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