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The Role of Polyamines in Metabolic Syndrome .


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1 Department of Biological Sciences, BITS Pilani, K K Birla, Goa Campus, Zuarinagar, Goa 403726, India ., India
     

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Metabolic syndrome has become a major health hazard worldwide, due to an increased consumption of fast food along with other unhealthy eating habits, decrease in physical activities and major lifestyle changes as a result of modernization. Metabolic syndrome is a non-communicable disease resulting in complications like type 2 diabetes, coronary diseases, stroke etc. The polyamines putrescine, spermidine, and spermine are naturally occurring cationic molecules essential for various cellular functions. Dysregulated polyamine circulation and metabolism have been linked to several conditions including cancer, type 2 diabetes mellitus, adipogenesis, altered lipid or glucose metabolism, chronic inflammation, etc. Several studies regarding the role of polyamines in metabolic syndrome in various models have been conducted, and the outcomes suggest a positive correlation in the prognosis of metabolic syndrome. This review provides a comprehensive discussion of metabolic syndrome, its prevalence in India and worldwide, factors causing the syndrome, and the role of polyamines in the pathogenesis of various complications of metabolic syndrome.

Keywords

Metabolic Syndrome (MetS), Obesity, Polyamines, Type 2 Diabetes Mellitus (T2D) .
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  • The Role of Polyamines in Metabolic Syndrome .

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Authors

Ananya Ajith
Department of Biological Sciences, BITS Pilani, K K Birla, Goa Campus, Zuarinagar, Goa 403726, India ., India
Kavya Chandra
Department of Biological Sciences, BITS Pilani, K K Birla, Goa Campus, Zuarinagar, Goa 403726, India ., India
Nayan Mate
Department of Biological Sciences, BITS Pilani, K K Birla, Goa Campus, Zuarinagar, Goa 403726, India ., India
Arnab Banerjee
Department of Biological Sciences, BITS Pilani, K K Birla, Goa Campus, Zuarinagar, Goa 403726, India ., India

Abstract


Metabolic syndrome has become a major health hazard worldwide, due to an increased consumption of fast food along with other unhealthy eating habits, decrease in physical activities and major lifestyle changes as a result of modernization. Metabolic syndrome is a non-communicable disease resulting in complications like type 2 diabetes, coronary diseases, stroke etc. The polyamines putrescine, spermidine, and spermine are naturally occurring cationic molecules essential for various cellular functions. Dysregulated polyamine circulation and metabolism have been linked to several conditions including cancer, type 2 diabetes mellitus, adipogenesis, altered lipid or glucose metabolism, chronic inflammation, etc. Several studies regarding the role of polyamines in metabolic syndrome in various models have been conducted, and the outcomes suggest a positive correlation in the prognosis of metabolic syndrome. This review provides a comprehensive discussion of metabolic syndrome, its prevalence in India and worldwide, factors causing the syndrome, and the role of polyamines in the pathogenesis of various complications of metabolic syndrome.

Keywords


Metabolic Syndrome (MetS), Obesity, Polyamines, Type 2 Diabetes Mellitus (T2D) .

References