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The Role of Polyamines in Metabolic Syndrome .


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1 Department of Biological Sciences, BITS Pilani, K K Birla, Goa Campus, Zuarinagar, Goa 403726, India ., India
     

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Metabolic syndrome has become a major health hazard worldwide, due to an increased consumption of fast food along with other unhealthy eating habits, decrease in physical activities and major lifestyle changes as a result of modernization. Metabolic syndrome is a non-communicable disease resulting in complications like type 2 diabetes, coronary diseases, stroke etc. The polyamines putrescine, spermidine, and spermine are naturally occurring cationic molecules essential for various cellular functions. Dysregulated polyamine circulation and metabolism have been linked to several conditions including cancer, type 2 diabetes mellitus, adipogenesis, altered lipid or glucose metabolism, chronic inflammation, etc. Several studies regarding the role of polyamines in metabolic syndrome in various models have been conducted, and the outcomes suggest a positive correlation in the prognosis of metabolic syndrome. This review provides a comprehensive discussion of metabolic syndrome, its prevalence in India and worldwide, factors causing the syndrome, and the role of polyamines in the pathogenesis of various complications of metabolic syndrome.

Keywords

Metabolic Syndrome (MetS), Obesity, Polyamines, Type 2 Diabetes Mellitus (T2D) .
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  • Saklayen MG. The global epidemic of the metabolic syndrome. Current Hypertension Reports. 2018; 20(2):12. https://doi.org/10.1007/ s11906-018-0812-z. PMid:29480368. PMCid: PMC5866840

  • Gupta A, Gupta V. Metabolic syndrome: what are the risks for humans? BioScience Trends. 2010; 4(5):204–12.

  • Grundy SM. Metabolic syndrome pandemic. Arteriosclerosis, Thrombosis, and Vascular Biology. 2008; 28(4):629–36. https://doi.

  • org/10.1161/ATVBAHA.107.151092. PMid:18174459

  • Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA. Diagnosis and management of the metabolic syndrome.

  • Circulation. 2005; 112(17):2735–52. https://doi.org/10.1161/CIRCULATIONAHA.105.169405. PMid:16157765

  • Samson SL, Garber AJ. Metabolic syndrome. Endocrinology and Metabolism Clinics of North America. 2014; 43(1):1–23. https:// doi.org/10.1016/j.ecl.2013.09.009. PMid:24582089

  • Kolovou GD, Anagnostopoulou KK, Salpea KD, Mikhailidis DP. The prevalence of metabolic syndrome in various populations. The American Journal of the Medical Sciences. 2007; 333(6):362–71. https://doi.org/10.1097/MAJ.0b013e318065c3a1. PMid:17570989

  • Health effects of overweight and obesity in 195 countries over 25 years. New England Journal of Medicine. 2017; 377(1):13–27.

  • https://doi.org/10.1056/NEJMoa1614362. PMid:28604169. PMCid:PMC5477817

  • Centers for disease control and prevention. National Diabetes Statistics Report website.

  • Palaniappan LP, Wong EC, Shin JJ, Fortmann SP, Lauderdale DS. Asian americans have greater prevalence of metabolic syndrome despite lower body mass index. International Journal of Obesity. 2011; 35(3):393–400. https://doi.org/10.1038/ijo.2010.152.

  • PMid:20680014. PMCid:PMC2989340

  • Hirode G, Wong RJ. Trends in the prevalence of metabolic syndrome in the United States, 2011-2016. Journal of the American Medical Association. 2020; 323(24):2526. https://doi.org/10.1001/jama.2020.4501. PMid:32573660. PMCid:PMC7312413

  • Krishnamoorthy Y, Rajaa S, Murali S, Rehman T, Sahoo J, Kar SS. Prevalence of metabolic syndrome among adult population in India: A systematic review and meta-analysis. PLOS ONE. 2020; 15(10). https://doi.org/10.1371/journal.pone.0240971.

  • PMid:33075086. PMCid:PMC7571716

  • Delavari A, Forouzanfar MH, Alikhani S, et al. First nationwide study of the prevalence of the metabolic syndrome and optimal cutoff points of waist circumference in the Middle East. Diabetes Care. 2009; 32(6):1092–7. https://doi.org/10.2337/dc08-1800.

  • PMid:19279302. PMCid:PMC2681035

  • Wang Y, Mi J, Shan X, et al. Is China facing an obesity epidemic and the consequences? The trends in obesity and chronic disease in China. International Journal of Obesity. 2007; 31(1):177–88. https://doi.org/10.1038/sj.ijo.0803354. PMid:16652128

  • Daniele G, Mendoza GR, Winnier D, et al. The inflammatory status score including IL-6, TNF-α, osteopontin, fractalkine, MCP-1 and adiponectin underlies whole-body insulin resistance and hyperglycemia in type 2 diabetes mellitus. Acta Diabetologica. 2014; 51(1):123–31. https://doi.org/10.1007/s00592-013-0543-1. PMid:24370923

  • Chandra A, Neeland IJ, Berry JD, et al. The relationship of body mass and fat distribution with incident hypertension. Journal of the American College of Cardiology 2014; 64(10):997–1002. https://doi.org/10.1016/j.jacc.2014.05.057. PMid:25190234

  • Zorena K, Jachimowicz-Duda O, Wąż P. The cut-off value for interleukin 34 as an additional potential inflammatory biomarker for the prediction of the risk of diabetic complications. Biomarkers. 2016; 21(3):276–82. https://doi.org/10.3109/13547 50X.2016.1138321. PMid:26849008

  • Körner A, Kratzsch J, Gausche R, et al. New predictors of the metabolic syndrome in children —Role of Adipocytokines. Pediatric Research. 2007; 61(6):640–5. https://doi.org/10.1203/01.pdr.0000262638.48304.ef. PMid:17426657

  • Lago F, Gómez R, Gómez-Reino JJ, et al. Adipokines as novel modulators of lipid metabolism. Trends in Biochemical Sciences.

  • ; 34(10):500–10. https://doi.org/10.1016/j.tibs.2009.06.008. PMid:19729309

  • Farooq R, Amin S, Hayat Bhat M, et al. Type 2 diabetes and metabolic syndrome—adipokine levels and effect of drugs.

  • Gynecological Endocrinology. 2017; 33(1):75–8. https://doi.org/10.1080/09513590.2016.1207165. PMid:27705028

  • Misra A, Soares MJ, Mohan V, et al. Body fat, metabolic syndrome and hyperglycemia in South Asians. Journal of Diabetes and its Complications. 2018; 32(11):1068–75. https://doi.org/10.1016/j.jdiacomp.2018.08.001. PMid:30115487

  • International Diabetes Federation: IDF Diabetes Atlas (2017). 8th ed; 2017.

  • Joshi SR, Anjana RM, Deepa M, et al. Prevalence of dyslipidemia in urban and rural India: The ICMR-INDIAB Study. PLoS ONE.

  • ; 9(5). https://doi.org/10.1371/journal.pone.0096808. PMid:24817067. PMCid:PMC4016101

  • Anjana RM, Deepa M, Pradeepa R, et al. Prevalence of diabetes and prediabetes in 15 states of India: Results from the ICMRINDIAB population-based cross-sectional study. The Lancet Diabetes and Endocrinology. 2017; 5(8):585–96. https://doi.

  • org/10.1016/S2213-8587(17)30174-2

  • Gupta R, Rao RS, Misra A, et al. Recent trends in epidemiology of dyslipidemias in India. Indian Heart Journal. 2017; 69(3):382– 92. https://doi.org/10.1016/j.ihj.2017.02.020. PMid:28648438. PMCid:PMC5485409

  • Madeo F, Eisenberg T, Pietrocola F, et al. Spermidine in health and disease. Science. 2018; 359(6374). https://doi.org/10.1126/ science.aan2788. PMid:29371440

  • Tabor CW, Tabor H. Methionine Adenosyltransferase (S -Adenosylmethionine Synthetase) and S -Adenosyl methionine Decarboxylase. 2006. p. 251–82. https://doi.org/10.1002/9780470123027.ch4. PMid:6364703

  • Wallace HM, Nuttall ME, Coleman CS. Polyamine recycling enzymes in human cancer cells; 1988. p. 331–44. https://doi.

  • org/10.1007/978-1-4684-5637-0_29. PMid:3076329

  • Dudkowska M, Lai J, Gardini G, et al. Agmatine modulates the in vivo biosynthesis and interconversion of polyamines and cell

  • proliferation. Biochimica et Biophysica Acta (BBA) – General Subjects. 2003; 1619(2):159–66. https://doi.org/10.1016/S0304-

  • (02)00476-2

  • Ramos-Molina B, Queipo-Ortuño MI, Lambertos A, et al. Dietary and gut microbiota polyamines in obesity- and age-related

  • diseases. Frontiers in Nutrition. 2019; 6. https://doi.org/10.3389/fnut.2019.00024. PMid:30923709. PMCid:PMC6426781

  • Kramer DL, Diegelman P, Jell J, et al. Polyamine acetylation modulates polyamine metabolic flux, a prelude to broader metabolic

  • consequences. Journal of Biological Chemistry. 2008; 283(7):4241–51. https://doi.org/10.1074/jbc.M706806200. PMid:18089555

  • Sivashanmugam M, Jaidev J, Umashankar V, Sulochana KN. Ornithine and its role in metabolic diseases: An appraisal. Biomedicine

  • and Pharmacotherapy. 2017; 86:185–94. https://doi.org/10.1016/j.biopha.2016.12.024. PMid:27978498

  • Welsh N. A role for polyamines in glucose-stimulated insulin-gene expression. Biochemical Journal. 1990; 271(2):393–7. https://

  • doi.org/10.1042/bj2710393. PMid:2241922. PMCid:PMC1149567

  • Welsh N, Sjöholm A. Polyamines and insulin production in isolated mouse pancreatic islets. Biochemical Journal. 1988;

  • (3):701–7. https://doi.org/10.1042/bj2520701. PMid:3138973. PMCid:PMC1149205

  • Mastracci TL, Robertson MA, Mirmira RG, et al. Polyamine biosynthesis is critical for growth and differentiation of the pancreas.

  • Scientific Reports. 2015; 5(1). https://doi.org/10.1038/srep13269 PMid:26299433. PMCid:PMC4547391

  • Fernandez-Garcia J, Delpino-Rius A, Samarra I, et al. Type 2 Diabetes is associated with a different pattern of serum polyamines:

  • A case-control study from the PREDIMED-Plus trial. Journal of Clinical Medicine. 2019; 8(1):71. https://doi.org/10.3390/

  • jcm8010071. PMid:30634588. PMCid:PMC6352090

  • Sharawy MH, El-Awady MS, Megahed N, et al. Attenuation of insulin resistance in rats by agmatine: role of SREBP-1c, mTOR and

  • GLUT-2. Naunyn-Schmiedeberg’s Archives of Pharmacology. 2016; 389(1):45–56. https://doi.org/10.1007/s00210-015-1174-6.

  • PMid:26449613

  • Niiranen K, Keinänen TA, Pirinen E, et al. Mice with targeted disruption of spermidine/spermine N 1 -acetyltransferase gene maintain nearly normal tissue polyamine homeostasis but show signs of insulin resistance upon aging. Journal of Cellular and Molecular Medicine. 2006; 10(4):933–45.PMid:17125596

  • Pirinen E, Kuulasmaa T, Pietilä M, et al. Enhanced polyamine catabolism alters homeostatic control of white adipose tissue mass, energy expenditure, and glucose metabolism. Molecular and Cellular Biology. 2007; 27(13):4953–67. https://doi.org/10.1128/ MCB.02034-06. PMid:17485446. PMCid:PMC1951486

  • Cerrada-Gimenez M, Tusa M, Casellas A, et al. Altered glucose-stimulated insulin secretion in a mouse line with activated polyamine catabolism. Transgenic Research. 2012; 21(4):843–53. https://doi.org/10.1007/s11248-011-9579-6. PMid:22180015

  • Yuan F, Zhang L, Cao Y, et al. Spermidine/spermine N1-acetyltransferase-mediated polyamine catabolism regulates beige adipocyte biogenesis. Metabolism. 2018; 85:298–304. https://doi.org/10.1016/j.metabol.2018.04.007. PMid:29715464. PMCid:PMC7269456

  • Codoñer-Franch P, Valls-Bellés V, Arilla-Codoñer A, Alonso-Iglesias E. Oxidant mechanisms in childhood obesity: the link between inflammation and oxidative stress. Translational Research. 2011; 158(6):369–84. https://doi.org/10.1016/j.trsl.2011.08.004.

  • PMid:22061044

  • Codoñer-Franch P, Tavárez-Alonso S, Murria-Estal R, et al. Polyamines are increased in obese children and are related to markers of oxidative/nitrosative stress and angiogenesis. The Journal of Clinical Endocrinology and Metabolism. 2011; 96(9):2821–5.

  • https://doi.org/10.1210/jc.2011-0531. PMid:21697248

  • Gao M, Zhao W, Li C, et al. Spermidine ameliorates non-alcoholic fatty liver disease through regulating lipid metabolism via AMPK. Biochemical and Biophysical Research Communications. 2018; 505(1):93–8. https://doi.org/10.1016/j.bbrc.2018.09.078.

  • PMid:30241944 44. Sadasivan SK, Vasamsetti B, Singh J, et al. Exogenous administration of spermine improves glucose utilization and decreases bodyweight in mice. European Journal of Pharmacology. 2014; 729:94–9. https://doi.org/10.1016/j.ejphar.2014.01.073.

  • PMid:24530553 45. Fernández ÁF, Bárcena C, Martínez-García GG, Tamargo-Gómez I, et al. Autophagy couteracts weight gain, lipotoxicity and pancreatic β-cell death upon hypercaloric pro-diabetic regimens. Cell Death and Disease. 2017; 8(8). https://doi.org/10.1038/ cddis.2017.373. PMid:28771229. PMCid:PMC5596561

  • Vuohelainen S, Pirinen E, Cerrada-Gimenez M, et al. Spermidine is indispensable in differentiation of 3T3-L1 fibroblasts to adipocytes. Journal of Cellular and Molecular Medicine. 2009; 14(6b):1683–92. https://doi.org/10.1111/j.1582-4934.2009.00808.x.

  • PMid:19538475. PMCid:PMC3829030

  • Pillion DJ. Differential effects of insulin, antibodies against rat adipocyte plasma membranes, and other agents that mimic insulin action in rat adipocytes. Metabolism. 1985; 34(11):1012–9. https://doi.org/10.1016/0026-0495(85)90072-1

  • Ma L, Ni Y, Hu L, et al. Spermidine ameliorates high-fat diet-induced hepatic steatosis and adipose tissue inflammation in preexisting obese mice. Life Sciences. 2021; 265. https://doi.org/10.1016/j.lfs.2020.118739. PMid:33186567

  • Ocaña-Wilhelmi L, Cardona F, Garrido-Sanchez L, et al. Change in serum polyamine metabolome pattern after bariatric surgery in obese patients with metabolic syndrome. Surgery for Obesity and Related Diseases. 2020; 16(2):306–11. https://doi.org/10.1016/j.

  • soard.2019.10.024. PMid:31813775 .


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  • The Role of Polyamines in Metabolic Syndrome .

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Authors

Ananya Ajith
Department of Biological Sciences, BITS Pilani, K K Birla, Goa Campus, Zuarinagar, Goa 403726, India ., India
Kavya Chandra
Department of Biological Sciences, BITS Pilani, K K Birla, Goa Campus, Zuarinagar, Goa 403726, India ., India
Nayan Mate
Department of Biological Sciences, BITS Pilani, K K Birla, Goa Campus, Zuarinagar, Goa 403726, India ., India
Arnab Banerjee
Department of Biological Sciences, BITS Pilani, K K Birla, Goa Campus, Zuarinagar, Goa 403726, India ., India

Abstract


Metabolic syndrome has become a major health hazard worldwide, due to an increased consumption of fast food along with other unhealthy eating habits, decrease in physical activities and major lifestyle changes as a result of modernization. Metabolic syndrome is a non-communicable disease resulting in complications like type 2 diabetes, coronary diseases, stroke etc. The polyamines putrescine, spermidine, and spermine are naturally occurring cationic molecules essential for various cellular functions. Dysregulated polyamine circulation and metabolism have been linked to several conditions including cancer, type 2 diabetes mellitus, adipogenesis, altered lipid or glucose metabolism, chronic inflammation, etc. Several studies regarding the role of polyamines in metabolic syndrome in various models have been conducted, and the outcomes suggest a positive correlation in the prognosis of metabolic syndrome. This review provides a comprehensive discussion of metabolic syndrome, its prevalence in India and worldwide, factors causing the syndrome, and the role of polyamines in the pathogenesis of various complications of metabolic syndrome.

Keywords


Metabolic Syndrome (MetS), Obesity, Polyamines, Type 2 Diabetes Mellitus (T2D) .

References