Comparison of Spot Urine Protein-Creatinine Ratio With 24-Hour Urine Protein in Glomerular Disease

Background: The protein/creatinine (P/C) ratio in urine samples has been used in the clinical management of patients with glomerular diseases. The aim of this study is to evaluate the correlation between the Spot urinary Protein/Creatinine ratio and 24 hour urinary protein in patients with glomerular disease.

Methods: It was a single centre, cross sectional study, conducted in Gauhati medical college and Hospital from July 2013 to June 2014. Patients admitted in department of nephrology due to glomerular disease were included for study. The relationship between the urine P/C ratio and the 24-hour protein excretion was assessed with the Pearson's correlation test.

Result: A total 70 patients were enrolled for the study. Among them, 27 were males. The mean age of patients was 35.47 ±10.96 years. The most common glomerular disease was Systemic Lupus Nephritis (SLE, 25 cases). There was a significant correlation between 24 hour urine protein and spot urine protein ratio (P/C) ratio (correlation coefficient = 0.93, P < 0.001).

Conclusion: This cross-sectional analysis corroborates the findings of previous studies, supporting the use of the spot urine protein ratio (P/C) ratio as an accurate test to define critical levels of proteinuria in patients with glomerular diseases.