International Journal of Innovative Research and Development

Avanendra Tiwari , Luv Kush

Abstract

MCBs have antianginal, antiarrhythmic, antihyperlipidemic, antihypertensive and cardiotonic types of bioactivities. MOAs of  MCBs followed the basic cardiopharmacological  mechanisms. The structural uniqueness of Autonomium chloride, Anthopleurine A, marine toxins and nucleosides imparted new clues of mechanisms. The stereoselective drug action of Octopamine was topographically rationalized.

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Avanendra Tiwari , Luv Kush

Abstract

Marine novel chemical entities have great potential for the therapeutical exploration. Their intelligent screening and application gifted pharmaceutical innovations in biomedications. We made a pioneer approach for designing the hypothetical pharmacophoric model for MCBs. This provides insight of various binding sites at cardiovascular receptors.

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Avanendra Tiwari , Luv Kush

Abstract

Lipinski's rule has predictive value for calculating drug likeness, We made a pioneer attempt to apply this rule to marine cardioactive biomolecules (MCBs).

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