International Journal of Innovative Research and Development

Shivam Kumar Singh ¹, Ankit Devshali ¹, Luv Kush ¹

Affiliations
1 Department of Applied Chemistry, Sardar Bhagwan Singh Post Graduate Institute of Biomedical Sciences and Research, Balawala, Dehradun, Uttarakhand, IN

Abstract

Ayurveda is Vedic medicine.  Cosmo biologically biological humors – Vata, Pitta and Kapha are influenced by zodiacal signs and planets.  Their malefic configurations are precursors of the pathogenesis.  Astro – pathology foretells well in advance for the prevention of health hazards.

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Shivam Kumar Singh ¹, Yogita Dobhal ², Veerma Ram ³, Luv Kush ⁴

Affiliations
1 Department of Applied Chemistry, Sardar Bhagwan Singh Post Graduate Institute of Biomedical Sciences and Research, Balawala, Dehradun, Uttarakhand, IN
2 Department of Pharmaceutical Sciences, Sardar Bhagwan Singh Post Graduate Institute of Biomedical Sciences and Research, Balawala, Dehradun, Uttarakhand, IN
3 Department Pharmaceutical Sciences, Sardar Bhagwan Singh Post Graduate Institute of Biomedical Sciences and Research, Balawala, Dehradun, Uttarakhand, IN
4 Professional certified Astrologer (California), US

Abstract

Dr. W. Folkert introduced the concept of elementenkreis for the therapeutical applications. He correlated atomic numbers of elements with the zodiacal signs of the twelve houses. His brilliant classical approach pioneered the interdisciplinary subject – Astropharmacology. We attempted the revival of his original contribution by translating the basic concepts of chemical pharmacology into astrological perception.

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Anil Bijlwan , Mohit Kumar Sharma , Tarun Thakur , Luv Kush

Abstract

The lifestyle drugs are the modern pharmaceutical innovations. They are Pharmacoeconomics assets of the 21st century. A new term QOL (quality oriented life improving drugs) has augmented their prospective potential. Marine biomolecules offered novel chemical entities (NCEs) of polypharmacophoric bioactions for improving the style and quality of life. The antidepressive, cosmeceutical, and aphrodisiacal potentials of marine novel chemical entities were explored in this study. 

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Tarun Thakur , Digvijay Gahtory , Luv Kush

Abstract

The facial cosmetics have attained the respectable status of life-style modifiers. Their prime aim is to enhance beauty, handsomeness and charming look. Recently innovative ingredients of modern facial formulations emerged as promising  advancement in facial cosmetology. They are herbal oils, animal milk, mineral containing clays and honey. Their special cosmetical qualities have formulative potentiation .

 

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Tarun Thakur , Akshay Negi , Luv Kush

Abstract

Akshay et.al ¹ proposed four types of drug-design, based on the rational models. Rationally designed ethnomedicinal formulations by traditional or indigenous natural ingredients should adopt the concept of ayurvedicophore². The extension of this applied for designing of ayurvedicphoric models of  facial life – style cosmeceuticals. We devised life-style, Anti-acne and Anti wrinkle ayurvediccophoric facial cosmeceuticals , having different herbal compositions with relevant bioactions for achieving the desired, therapeutical objectives.

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Mohit Kumar Sharma , Luv Kush

Abstract

The chemopharmacological correlation is based on the principles of chemical pharmacology. Possibly it may be new attempt to design antidepressant of therapeutical specificity, by correlating the antidepressive  structures of natural origin and synthetic through molecular association or simplification. Serotonim and Norepinepherine selected as the structural standards. They have Indolyl, catechol, aliphatic chain of two carbons and the protonated tertiary nitrogen at the physiological pH are topographical entities for the receptor affinity and intrinsic efficacy of pharmacodynamic value, thus induce the conformational change for the biological response.The structural diveregence of non-SSRIs was rationalized by agumentation, receptor diversification and topographical selectivity. Mitrazepin, Neurontin, Pregabalin and Tramadol have special structural values. Receptor specificity and critical moieties of agonist, partial agonist and antagonist studied  for finding out their role in correlation. The overall chemopharmacological correlation has empirically defined the partial components of antidepressive receptor specificity as indolyl, tertiary nitrogen, catechol and aryls. The concepts of isosterism and bioisosterism were not considered. The topographical entities of antidepressants belonging to natural and synthetic, termed as critical for utilizing them for the molecular design.

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Mohit Kumar Sharma , Veerma Ram , LUV Kush

Abstract

Our new approach explored the phytopharmacotherapeutical significance of antidepressive TNPs through theoretical studies based on the antidepressant chemical structures.

 

Keywords

Antidepressive, 5-HT (Serotonin), natural products, pharmacophoric, terrestrial.

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Avanendra Tiwari , Luv Kush

Abstract

MCBs have antianginal, antiarrhythmic, antihyperlipidemic, antihypertensive and cardiotonic types of bioactivities. MOAs of  MCBs followed the basic cardiopharmacological  mechanisms. The structural uniqueness of Autonomium chloride, Anthopleurine A, marine toxins and nucleosides imparted new clues of mechanisms. The stereoselective drug action of Octopamine was topographically rationalized.

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Tarun Thakur , Luv Kush

Abstract

The facial cosmeceuticals enhance the charming look and attractive appeal. They have achieved the  pharmaceutical distinction as life- style potentiaters in 21^st century at social and professional levels. The forty five modern formulations of facial cosmetics were studied for t identifying their cosmeceutical structures and  bioactions in order to design chemically oriented FC for plausible formulations. It is composed of chemobiological functionalities for facial skin interaction. The cationic, hydrophobic, H-bonding and pi-pi stacking sites structured the hypothetical FC.

 

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Akshay Negi , Luv Kush

Abstract

The Ayurvedic Formulations Are Hair Growth Promoters. They Have Emerged As The Popular Life-Style Medications And Achieved Phenomenal Phamacoeconomical Success. They Improve Looks, Self-Image, Life Style And Quality Of Life. Theoretically, Their Formulation Chemistry And Bioactions Were Elucidated For Designing The Hair Growth Promoting Ayurvedicophore.

 

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Avanendra Tiwari , Luv Kush

Abstract

Marine novel chemical entities have great potential for the therapeutical exploration. Their intelligent screening and application gifted pharmaceutical innovations in biomedications. We made a pioneer approach for designing the hypothetical pharmacophoric model for MCBs. This provides insight of various binding sites at cardiovascular receptors.

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Avanendra Tiwari , Luv Kush

Abstract

Lipinski's rule has predictive value for calculating drug likeness, We made a pioneer attempt to apply this rule to marine cardioactive biomolecules (MCBs).

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Avanedra Tiwari , Luv Kush

Abstract

Biomedications of natural origin represent conventional therapies through indigenous formulations.MCBs have antianginal, antiarrhythmic, antihyperlipidemic, antihypertensive, and cardiotonic activities. Their structural uniqueness was explored for possible novel modes of action.

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Akshay Negi , Luv kush

Abstract

Psychosocially, hair related pharmaceuticals have become the promising life style drugs. They prevent hair loss and promote dense as well as glowing hair. They improve modern youth’s social charm and psychological appeal. Hair cosmetics are the beautifiers of human personality. To achieve this the chemical parameters of hair trichophore should be delineated. A model of androgenic hair trichophore has hypothetically derived. It is made up of heteroatoms (H-bonding), Aryl,heteroaryl, alkyl, alkenyl ( Vander wal interaction)Steroidal conjugated >c=o, hydroxyl for hydrophobic and H-bonding and anagen phase stimulators (Naturalproducts e.g Capsicum,Niacin,Ursolic acid and Bio-flavonoids.

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