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International Journal of Innovative Research and Development, Vol 3, No 7 (2014), Pagination:
Abstract
Background: The pharmacological effect of Gum Arabic with and without laser exposure is largely unknown. Objective: This study aimed to explore the pharmacological effect of GA on hepatic hyperplasia induced by diethylnitrosamine (DENA) in Balb-C mice and the changes in lipid peroxidation, apoptosis and histopathological changes in hepatic hyperplasia mice with or without laser irradiation. Results: In vivo studies showed that GA was biologically inactive expect when combined with laser irradiation in healthy and in hepatic hyperplasia mice, it leds to elevation in lipid peroxidation level. Conclusion: GA is safe and did not induce biological alterations. Co-administration of GA with laser induced lipid peroxidation.
Keywords
hepatic hyperplasia mice, gum Arabic, apoptosis, MDA, histopathology
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